Results 221 to 230 of about 187,990 (300)

Acute phencyclidine inhalation injury in the emergency department: a rare cause of acute respiratory distress syndrome and alveolar haemorrhage. [PDF]

World J Emerg Med
Deniz İlgün J, Çövüt Y, Tuna C, Erkekoğlu S, Hastürkoğlu S, Güler S.   +5 more
europepmc   +1 more source

Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Hepatocellular carcinoma (HCC), the third leading cause of cancer‐related deaths worldwide, has limited treatment options and high mortality rate. We previously used a bioinformatics approach to identify niclosamide (NIC) as a promising repurposed drug candidate for HCC.
Mingdian Tan, Wei Ye, Yi Liu, Xiaowu Chen, Lakshmi Huttad, Mei‐Sze Chua, Samuel So   +6 more
wiley   +1 more source

Evidence that Mast Cells Regulate the Cough Hypersensitivity Associated with Eosinophilic Bronchitis. [PDF]

Lung
Yu L, Liu Q, Canning BJ.
europepmc   +1 more source

Molecular hydrogen protects against sepsis‐induced cardiomyopathy through improving Golgi stress‐mediated autophagy, inflammation and apoptosis

British Journal of Pharmacology, EarlyView.
Background and Purpose Sepsis‐induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular ...
Shuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, Shuaijie Pei, Xiaofan Huang, Lina Zhao, Keliang Xie   +9 more
wiley   +1 more source

Oxygen therapy in the intensive care unit. [PDF]

Med Gas Res
Wang P, Huang Q, Liu B, Xu Q, Li X, Feng G, Liu Y.   +6 more
europepmc   +1 more source

Anti‐nociceptive action of leonurine through TRPA1 and TRPV4 channels modulation

British Journal of Pharmacology, EarlyView.
Background and Purpose Leonurine, a pseudoalkaloid derived from Leonotis leonurus, has been traditionally used in herbal medicine to alleviate conditions such as headaches and abdominal discomfort. Its therapeutic effects are often attributed to potential antioxidant properties; however, the precise molecular mechanisms remain poorly understood ...
Matilde Marini, Lorenzo Landini, Elisabetta Coppi, Martina Tesi, Elisa Bellantoni, Martina Chieca, Emma Beatrice Croce, Lorenzo Bonacchi, Giulia Brancolini, Piero Bruschi, Daniel Souza Monteiro de Araújo, Gaetano De Siena, Alexandra Dimitrova, Alessandra Mastricci, Henrique Rocha Mendonça, Irene Scuffi, Martina Venturini, Luiza Dos Santos Heringer, Fabio Vaiano, Romina Nassini, Francesco De Logu   +20 more
wiley   +1 more source

Synergistic Drug-Induced Diffuse Alveolar Hemorrhage in a Polysubstance User: A Case of Inhaled Cocaine and Fentanyl Toxicity. [PDF]

Cureus
Lopez-Pena BA, Canevaro-Lugo N, Davila-Cardona AU, Ruiz-Ramos M, Perez-Mitchell MC, Fernandez-Gonzalez R.   +5 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Rapid improvement in postpartum pulmonary hypertension associated with hereditary hemorrhagic telangiectasia: A case report and review of literature. [PDF]

World J Clin Cases
Hao SY, Muhetaer Y, Zheng X, Long YL, Song JQ, Zhong M.   +5 more
europepmc   +1 more source

Inhibitory Effects of 3′,4′‐Dihydroxyflavonol in a Rabbit Model of Minimally Invasive Bleb Surgery With PreserFlo MicroShunt

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background The success of minimally invasive bleb surgery (MIBS) such as the PreserFlo MicroShunt (PFMS) is limited by post‐operative bleb fibrosis. Current clinical practice prescribes the use of off‐label cytotoxic antimetabolites such as Mitomycin C (MMC) as antifibrotic therapy.
Zoe Pasvanis, Roy C. K. Kong, Elsa C. Chan, Jennifer C. Fan Gaskin   +3 more
wiley   +1 more source