Results 221 to 230 of about 85,576 (347)

PBX1 Improves Cognition and Reduces Amyloid‐β Pathology in APP/PS1 Mice by Transcriptionally Activating the CRTC2–CREB Pathway

open access: yesAging Cell, EarlyView.
We found that the transcription factor PBX1 is markedly downregulated in patients with Alzheimer's disease and in disease models. Restoring PBX1 reduces Aβ pathology and rescues cognitive deficits. Mechanistically, PBX1 directly activates the transcription of CRTC2 and enhances p‐CREB signaling, thereby conferring neuroprotection.
Zinan Liu   +8 more
wiley   +1 more source

Identifying Clinical Variations Across NSW Public Dental Service: An Essential Step to Develop a Roadmap for Value‐Based Oral Healthcare

open access: yesAustralian Dental Journal, EarlyView.
ABSTRACT Objective This research examines the extent of clinical variation across the NSW public dental service, the largest in Australia. Findings may assist policy makers in reducing variation of care and inequity towards value‐based oral healthcare. Methods Four years of demographic and treatment data, for 741,450 patients between 1 July 2019 and 30
Albert Yaacoub, Tony Skapetis
wiley   +1 more source

Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History

open access: yesAllergy, EarlyView.
In this two‐phase study, school‐aged children were classified as at risk or no‐risk based on severe attacks during one‐year follow‐up. Four types of prediction models were developed. Salivary bacteria and serum inflammatory markers, while informative alone, complement past asthma attacks in predicting future attack risk.
Shahriyar Shahbazi Khamas   +59 more
wiley   +1 more source

Protective Role for Itaconate During Inhaled Allergen Challenge

open access: yesAllergy, EarlyView.
Itaconate levels decrease in sputum following allergen inhalation in mild asthmatics, suggesting a dynamic metabolic response to airway challenge. Genetic deletion of Acod1 in mice did not alter airway inflammation or remodelling in response to chronic HDM exposure.
Gesa J. Albers   +16 more
wiley   +1 more source

Non-invasive respiratory support in pediatric patients with acute hypoxemic respiratory failure: a systematic review and network meta-analysis of randomized controlled trials. [PDF]

open access: yesEClinicalMedicine
Feng Y   +13 more
europepmc   +1 more source

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