Results 81 to 90 of about 37,366 (283)

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Seawater oxygen isotopes of the Portuguese margin

, 2017
Seawater oxygen isotopes of the Portuguese ...
Voelker, Antje H L, Patrick Grunert (7881509), Isabel Maria de Paiva Pinto Mendes (8020268), Mendes, Isabel Maria de Paiva Pinto, Antje H L Voelker (6962852), Grunert, Patrick, Ángela García-Gallardo (6973391), Werner E Piller (8020271), García-Gallardo, Ángela, Piller, Werner E   +9 more
core   +1 more source

Seawater oxygen isotopes as a tool for monitoring future meltwater from the Antarctic ice-sheet

Communications Earth & Environment
To reduce uncertainties in future sea level projections, it is necessary to closely monitor the evolution of the Antarctic ice-sheet. Here, we show that seawater oxygen isotopes are an effective tool to monitor ice-sheet freshwater discharge and its ...
Hyuna Kim, Axel Timmermann
doaj   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

An oxygen isotope record of lacustrine opal from a European Maar indicates climatic stability during the Last Interglacial

, 2001
The penultimate temperate period, 127–110 ka before present (BP), bracketed by abrupt shifts of the global climate system initiating and terminating it, is considered as an analogue of the Holocene because of a similar low global ice‐volume.
Rietti-Shati, M, de Beaulieu, J, Svobodova, H, Reille, M, Shemesh, A, Battarbee, RW, Rioual, P, Andrieu, V   +7 more
core  

Short-term fate of phytodetritus in sediments across the Arabian Sea Oxygen Minimum Zone [PDF]

, 2007
The short-term fate of phytodetritus was investigated across the Pakistan margin of the Arabian Sea at water depths ranging from 140 to 1850 m, encompassing the oxygen minimum zone (~100–1100 m).
Middelburg, J.J., Soetaert, K.E.R., Levin, L. A., Andersson, J.H., Woulds, C., G. L. Cowie, L. A. Levin, Cowie, G.L., Levin, L.A., Soetaert, K., Middelburg, J. J., J. H. Andersson, Schwartz, M., Cowie, Gregory, K. Soetaert, M. Schwartz, J. J. Middelburg, Andersson, J. H., C. Woulds, Cowie, G. L.   +19 more
core   +1 more source

Mapping oxygen stable isotopes of precipitation in Italy

Journal of Hydrology: Regional Studies, 2016
Study region: Italy. Study focus: The oxygen isotope composition from 266 pluviometers was used to study the spatial variability of δ18O and its relationship with Italian orography. The local meteoric water lines (LMWLs) of northern, southern and central
Francesca Giustini, Mauro Brilli, Antonio Patera   +2 more
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Nitrogen Isotopes in the Global Ocean [PDF]

, 2013
Nitrogen is an essential nutrient for life. Its low abundance throughout much of the sunlit surface ocean limits the growth of primary producers that form the base of ocean ecosystems.
Somes, Christopher J., Somes, Christopher   +1 more
core