Results 121 to 130 of about 6,370,943 (303)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Rational Design of Covalent Organic Frameworks for Oxygen Electrocatalysis: Recent Advances and Mechanistic Insights

Nano-Micro Letters
Highlights Comprehensive classification of covalent organic frameworks (COFs)-based electrocatalysts based on the nature of active sites. Systematic review of structural design and functional synthesis strategies for enhancing oxygen electrocatalysis. In-
Xinyan Zhang, Ting Chen, Zhengping Chen, Gao Chen, Yanping Zhu, Xiaogang Zhang   +5 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

First Principles Study of the Structure–Performance Relation of Pristine W_n+1C_n and Oxygen-Functionalized W_n+1C_nO₂ MXenes as Cathode Catalysts for Li-O₂ Batteries

Nanomaterials
Li-O2 batteries are considered a highly promising energy storage solution. However, their practical implementation is hindered by the sluggish kinetics of the oxygen reduction (ORR) and oxygen evolution (OER) reactions at cathodes during discharging and ...
Liwei Zhu, Jiajun Wang, Jie Liu, Ruxin Wang, Meixin Lin, Tao Wang, Yuchao Zhen, Jing Xu, Lianming Zhao   +8 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Interfacially Coupled and Synergistic Effect of Ag/Co3O4‐C Nanocomposites for Enhanced Oxygen Reduction (ORR) and Evolution (OER) Reaction

Advanced Science
Overpotentials associated with the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) remain key challenges hindering the practical deployment of advanced electrochemical energy conversion technologies such as alkaline fuel cells.
Adnan Qaseem, Fuyi Chen, Arslan Shabbir, Mohsin Saleem, Jung Hyuk Koh, Muhammad Zubair Khan, Imran Shakir, Muhammad Talha Masood, Kanagat Kishibayev   +8 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Cobalt based Non-precious Electrocatalysts for Oxygen Reduction Reaction in Proton Exchange Membrane Fuel Cells

, 2010
Proton exchange membrane fuel cells(PEMFCs) have received wide attention over the recent few decades as an environmental benign technology, because of low emissions and high conversion efficiency for vehicle and portable devices.
钟和香, 马原蔚, 金虹, 张华民, 徐婷   +4 more
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