Results 81 to 90 of about 6,370,943 (303)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Characterization of Pd Nanocomposites for the Oxygen-Reduction Reaction

Proceedings
Carbon nanocomposites are essential supports in fuel cell catalysts, ensuring dispersion, anchoring, and reactant access. Here, we demonstrated an in situ synthesis of Pd nanoparticles using electrogenerated hydrophilic carbon (EHC) matrix that acts ...
Ilias Ouanzi, Maria C. Oliveira
doaj   +1 more source

Graphene-Based Oxygen Reduction Reaction Catalysts for Metal Air Batteries

, 2015
In the past few years, the metal air batteries developed fast due to their remarkably high theoretical energy output. So far, the oxygen reduction reaction catalysts still have been the bottleneck for high power application of metal air batteries because
Xue Yejian, Miao He, Zhou Xufeng, Liu Zhaoping   +3 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Oxygen-Reconstituted Active Species of Single-Atom Cu Catalysts for Oxygen Reduction Reaction

Research, 2020
Identification of an active center of catalysts under realistic working conditions of oxygen reduction reaction (ORR) still remains a great challenge and unclear.
Liu Yang, Haoxiang Xu, Huibing Liu, Xiaofei Zeng, Daojian Cheng, Yan Huang, Lirong Zheng, Rui Cao, Dapeng Cao   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Nitrogen-Doped Carbon Nanodots@Nanospheres as An Efficient Electrocatalyst for Oxygen Reduction Reaction [PDF]

, 2015
In this work, nitrogen-doped carbon nanodots (N-CNDs) with sizes of 2–6 nm were successfully synthesized by hydrothermal treatment of natural biomass (e.g., fresh grass) at 180 °C for 10 h.
Liu, Porun, Zhao, Huijun, An, Taicheng, Chen, Jiangyao, Chen, Ying, Zhang, Haimin, Wang, Yun, Li, Yibing   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Sugar-Based Catalysts For Oxygen Reduction Reaction

, 2016
Since a time platinum and platinum-alloys are considered most effective and reliable catalysts for oxygen reduction in PEM fuel cells. In fact, performances of these devices are severely limited by the kinetics of the oxygen reduction reaction (ORR) at ...
F. Nobili, M. Renzi, M. Longhi, S. Marzorati   +3 more
core   +2 more sources