Results 111 to 120 of about 7,143,446 (406)

Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model

open access: yes, 2014
Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy.
A. Lorz   +37 more
core   +1 more source

Cluster headache management and beyond [PDF]

open access: yes, 2015
The therapeutic management of cluster headache is based on a very stable triad of drugs. Acute treatment has, in subcutaneous sumatriptan, its gold standard if compared to pure oxygen or indomethacin.
Martelletti, Paolo
core   +1 more source

High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis

open access: yesCritical Care, 2017
BackgroundHigh-flow nasal cannula oxygen (HFNC) is a relatively new therapy used in adults with respiratory failure. Whether it is superior to conventional oxygen therapy (COT) or to noninvasive mechanical ventilation (NIV) remains unclear.
Hui-ying Zhao   +4 more
semanticscholar   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

Knowledge and Practice of Nurses towards Oxygen Therapy in the Public Hospitals of Harari Region, Ethiopia

open access: yesJournal of Research Development in Nursing and Midwifery, 2021
Background: Oxygen therapy refers to the administration of oxygen as a medical intervention. Inadequate oxygen administration may result in serious complications including cardiac arrhythmias, tissue injury and ultimately cerebral damage. The aim of this
Arif Jamie
doaj  

Amplified singlet oxygen generation in metallated-porphyrin doped conjugated polymer nanoparticles [PDF]

open access: yes, 2018
We report on the mechanism and efficiencies of singlet oxygen O2(1Δg) generation of nanoparticles (NP) of the conjugated polymer (CP) poly(9,9-dioctylfluorene-alt-benzothiadiazole) (F8BT) doped with platinum octaethylporphyrin (PtOEP) suspended in water.
Chesta, Carlos Alberto   +7 more
core   +2 more sources

Effect of high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure: a meta-analysis of randomized controlled trials

open access: yesCanadian Medical Association Journal, 2017
BACKGROUND: Conflicting recommendations exist on whether high-flow nasal cannula (HFNC) oxygen therapy should be administered to adult patients in critical care with acute hypoxemic respiratory failure.
X. Ou   +4 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

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