Results 111 to 120 of about 1,103,678 (351)

Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model

, 2014
Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy.
A. Lorz, A. Lorz, A. Wu, A.L. Correia, A.O. Pisco, A.S. Silva, B. Baguley, C. Bock, D. Woods, D.W. McMillin, E.S. Nakasone, F.A. Meineke, G. Lambert, H. Zahreddine, H.M. Byrne, I. Bozic, J. Foo, J. Foo, J. Greene, J.J. Cunningham, J.J. Kim, J.J. Lee, K. Cheung-Ong, M. Dean, M. Sawicka, M.M. Hadjiandreou, N.L. Komarova, N.L. Komarova, O. Lavi, O. Lavi, O. Trédan, P. Karran, P.A. Orlando, P.P. Provenzano, S. Rottenberg, S.M. Mumenthaler, T. Brocato, T.L. Jackson   +37 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Ozone adjunct treatment in facing multidrug‐resistant bacteria?

Clinical Case Reports, 2023
Salvatore Chirumbolo, Luigi Valdenassi, Marianno Franzini   +2 more
doaj   +1 more source

The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]

, 2008
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Transtracheal Oxygen Therapy and Bronchial Toileting using Minitracheostomy in Patients with Advanced Respiratory Failure

, 2022
Arjun Khanna, J. C. Suri, M.K. Sen, Ayush Gupta   +3 more
openalex   +1 more source

A nationwide survey on the use of Heated Humidified High Flow Oxygen therapy on the paediatric wards in the UK: current practice and research priorities [PDF]

, 2020
Osama Hosheh, Christopher T Edwards, Padmanabhan Ramnarayan   +2 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Adaptive high flow oxygen therapy: New concept

Journal of Mechanical Ventilation
Background High-flow oxygen therapy (HFOT) is increasingly utilized in clinical settings due to its potential to improve oxygenation, patient comfort and possibly outcomes in different respiratory failure states. The potential benefits of HFOT include
Sorawit Ongsupankul, Achal Dhupa, Ehab Daoud   +2 more
doaj   +1 more source