Results 11 to 20 of about 10,869 (148)
Identification of novel regulatory cholesterol metabolite, 5-cholesten, 3β,25-diol, disulfate. [PDF]
PLoS ONE, 2014 Oxysterol sulfation plays an important role in regulation of lipid metabolism and inflammatory responses. In the present study, we report the discovery of a novel regulatory sulfated oxysterol in nuclei of primary rat hepatocytes after overexpression of ...
Shunlin Ren +6 more
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GPR183 Regulates 7α,25-Dihydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell
Molecules, 2022 7α,25-dihydroxycholesterol (7α,25-DHC) is an oxysterol synthesized from 25-hydroxycholesterol by cytochrome P450 family 7 subfamily B member 1 (CYP7B1) and is a monooxygenase (oxysterol-7α-hydroxylase) expressed under inflammatory conditions in various ...
Jae-Sung Kim +11 more
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Cells, 2019 7-Ketocholesterol (7-KC) is a cholesterol oxidation product with several biological functions. 7-KC has the capacity to cause cell death depending on the concentration and specific cell type.
Jessica Liliane Paz +8 more
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Metabolic Control of Innate Lymphoid Cell Migration
Frontiers in Immunology, 2019 Innate lymphoid cells (ILCs) are specialized immune cells that rapidly respond to environmental challenges, such as infection and tissue damage. ILCs play an important role in organ homeostasis, tissue repair, and host defense in the mucosal tissues ...
Tim Willinger
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25-Hydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell Line
Molecules, 2021 25-hydroxycholesterol (25-HC) is an oxysterol synthesized from cholesterol by cholesterol-25-hydroxylase during cholesterol metabolism. The aim of this study was to verify whether 25-HC induces oxiapoptophagy in fibroblasts.
Jae-Seek You +11 more
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The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease
Antioxidants, 2021 The development of Alzheimer’s disease (AD) is influenced by several events, among which the dysregulation of cholesterol metabolism in the brain plays a major role.
Paola Gamba +7 more
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Journal of Lipid Research, 2009 Side chain oxysterols are cholesterol derivatives thought to signal the abundance of cell cholesterol to homeostatic effector proteins. Here, we investigated how plasma membrane (PM) cholesterol might regulate 27-hydroxycholesterol (HC) biosynthesis in ...
Yvonne Lange +5 more
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Determination of Pharmaceuticals, Heavy Metals, and Oxysterols in Fish Muscle
Molecules, 2021 The present study aimed to assess the levels of 98 multi-class pharmaceuticals including cardiovascular drugs, antidepressants, hypnotics, antibiotics, and sulfonamides occurring in the muscle tissue of fish caught in the Baltic Sea.
Barbara Bobrowska-Korczak +5 more
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A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons
Frontiers in Neuroscience, 2018 Oxysterol analogs that modulate NMDA receptor function are candidates for therapeutic development to treat neuropsychiatric disorders. However, the cellular actions of these compounds are still unclear.
Daniel M. Chen +10 more
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Journal of Lipid Research, 2021 Oxysterols are oxidized derivatives of cholesterol that play regulatory roles in lipid biosynthesis and homeostasis. How oxysterol signaling coordinates different lipid classes such as sterols and triglycerides remains incompletely understood.
Ofer Moldavski +11 more
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