Results 51 to 60 of about 10,869 (148)
Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes
British Journal of Pharmacology, EarlyView.Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley +1 more source
Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum
Molecular Microbiology, EarlyView.During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol +5 more
wiley +1 more source
Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation
Nature CommunicationsPolycystin-1 (PC-1) and PC-2 form a heteromeric ion channel complex that is abundantly expressed in primary cilia of renal epithelial cells. This complex functions as a non-selective cation channel, and mutations within the polycystin complex cause ...
Kodaji Ha +8 more
doaj +1 more source
Human breast milk lipoproteins: A preliminary biochemical characterization
Experimental Physiology, EarlyView.Abstract Human breast milk (BM) is an essential fluid for infant development, with a dynamic composition adapted to the infant's needs. It contains bioactive lipids like cholesterol, typically transported by lactosomes, extracellular vesicles, and milk fat globules. However, classic cholesterol‐carrying lipoproteins have not been described in BM.
Gabriela Arenas +3 more
wiley +1 more source
Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol
Journal of Lipid Research, 2002 Oxidized LDL (OxLDL) is composed of many potentially proatherogenic molecules, including oxysterols. Of the oxysterols, 7-ketocholesterol (7-KC) is found in relatively large abundance in OxLDL, as well as in atherosclerotic plaque and foam cells in vivo.
John M. Hayden +6 more
doaj +1 more source
Experimental Physiology, EarlyView.Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores +4 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade +13 more
wiley +1 more source
Analytical methods of oxysterol determination
Grasas y Aceites, 1994 This paper deal with the main aspects of the analysis of oxysterols. This analytical problem is quite new and many questions involved are still controversial.
F. Guardiola +3 more
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Antioxidants, 2020 The aim of this study was to present overall lipid profile of organisms with ongoing neoplastic process and applied diet supplementation with pomegranate seed oil (PSO) and bitter melon extract (BME).
Agnieszka Białek +5 more
doaj +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.Zinc supplementation in diabetes is associated with improved insulin sensitivity, lipid profile, antioxidant status and reduced inflammation, without significant effects on glycemic indices. Overall, evidence from randomized trials supports zinc as a beneficial metabolic adjunct with moderate‐to‐high certainty. ABSTRACT Objectives Diabetes mellitus (DM)
Jessica Paola Loaiza‐Giraldo +15 more
wiley +1 more source