Results 61 to 70 of about 10,829 (193)
Oxysterols as therapeutic targets [PDF]
British Journal of Pharmacology, 2021 Mark, Nixon, Ruth, Andrew
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The role of oxysterols in vascular ageing [PDF]
The Journal of Physiology, 2016 AbstractThe ageing endothelium progressively loses its remarkable and crucial ability to maintain homeostasis of the vasculature, as it acquires a proinflammatory phenotype. Cellular and structural changes gradually accumulate in the blood vessels, and markedly in artery walls.
Simona, Gargiulo +4 more
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Molecules, 2018 Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive human disease caused by mutations in the gene encoding 7-dehydrocholesterol (7DHC) reductase (DHCR7), resulting in abnormal accumulation of 7DHC and reduced levels of cholesterol in bodily ...
Steven J. Fliesler, Libin Xu
doaj +1 more source
Human breast milk lipoproteins: A preliminary biochemical characterization
Experimental Physiology, EarlyView.Abstract Human breast milk (BM) is an essential fluid for infant development, with a dynamic composition adapted to the infant's needs. It contains bioactive lipids like cholesterol, typically transported by lactosomes, extracellular vesicles, and milk fat globules. However, classic cholesterol‐carrying lipoproteins have not been described in BM.
Gabriela Arenas +3 more
wiley +1 more source
Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles
Advanced Science, Volume 13, Issue 33, 15 June 2026.Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu +6 more
wiley +1 more source
Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol
Journal of Lipid Research, 2002 Oxidized LDL (OxLDL) is composed of many potentially proatherogenic molecules, including oxysterols. Of the oxysterols, 7-ketocholesterol (7-KC) is found in relatively large abundance in OxLDL, as well as in atherosclerotic plaque and foam cells in vivo.
John M. Hayden +6 more
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Advanced Science, Volume 13, Issue 33, 15 June 2026.This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang +9 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1179-1191, June 2026.ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson +1 more
wiley +1 more source
Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation
Nature CommunicationsPolycystin-1 (PC-1) and PC-2 form a heteromeric ion channel complex that is abundantly expressed in primary cilia of renal epithelial cells. This complex functions as a non-selective cation channel, and mutations within the polycystin complex cause ...
Kodaji Ha +8 more
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Analytical methods of oxysterol determination
Grasas y Aceites, 1994 This paper deal with the main aspects of the analysis of oxysterols. This analytical problem is quite new and many questions involved are still controversial.
F. Guardiola +3 more
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