Results 61 to 70 of about 10,869 (148)

Assays of plasma dehydrocholesteryl esters and oxysterols from Smith-Lemli-Opitz syndrome patients[S]

Journal of Lipid Research, 2013
Smith-Lemli-Opitz syndrome (SLOS) is caused by mutations in the gene encoding 3β-hydroxysterol-Δ7-reductase and as a result of this defect, 7-dehydrocholesterol (7-DHC) and 8-dehydrocholesterol (8-DHC) accumulate in the fluids and tissues of patients ...
Wei Liu, Libin Xu, Connor R. Lamberson, Louise S. Merkens, Robert D. Steiner, Ellen R. Elias, Dorothea Haas, Ned A. Porter   +7 more
doaj   +1 more source

Baat‐Deficient Mice Recapitulate Elevated 7α‐Hydroxy‐3‐Oxo‐4‐Cholestenoic Acid Observed in a Japanese Patient With BAAT Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACTBile acid Coenzyme A: amino acid N‐acyltransferase (BAAT) catalyzes the conjugation of bile acids with taurine or glycine, a process essential for bile acid solubility and intestinal lipid absorption. Mutations in BAAT cause an inborn error of bile acid metabolism, typically characterized by reduced conjugated bile acids and fat‐soluble vitamin
Soma Koga, Hajime Takei, Ryutaro Tamura, Yugo Takaki, Hiroyuki Kusuhara, Hiroshi Nittono, Hisamitsu Hayashi   +6 more
wiley   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source

Oxysterols contribute to immune cell recruitment in SLE skin lesions

Arthritis Research & Therapy
Background Abnormal oxysterol metabolism has been observed in the peripheral blood of SLE patients, but its role in systemic lupus erythematosus (SLE) skin lesions remains unclear.
Xiaoyun Chen, Lianlian Ouyang, Sujie Jia, Ming Zhao   +3 more
doaj   +1 more source

OXYSTEROLS AND PHYTOSTEROLS IN HUMAN PATHOPHYSIOLOGY: Adipocytes in tumour microenvironment promote chemoresistance in triple-negative breast cancer through oxysterols

Redox Experimental Medicine
Objective: Triple-negative breast cancer (TNBC) patients with excess adipose tissue experience poorer disease-free survival than those with a healthy body mass index. Adipocytes store and release cholesterol, which can be hydroxylated to form oxysterols.
Alex Websdale, Yusur Al-Hilali, Baek Kim, Bethany J Williams, Laura Wastall, Hanne Roberg-Larsen, Thomas A Hughes, Giorgia Cioccoloni, James L Thorne   +8 more
doaj   +1 more source

Rapid hepatic metabolism of 7-ketocholesterol in vivo: implications for dietary oxysterols

Journal of Lipid Research, 1999
7-Ketocholesterol is a major dietary oxysterol and the predominant non-enzymically formed oxysterol in human atherosclerotic plaque. We tested the hypothesis that 7-ketocholesterol is preferentially retained by tissues relative to cholesterol in vivo. To
Malcolm A. Lyons, Samir Samman, Lissa Gatto, Andrew J. Brown   +3 more
doaj   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

Targeting progressive multiple sclerosis: Toward mechanism‐informed precision medicine

Journal of Internal Medicine, Volume 300, Issue 3, Page 238-257, September 2026.
Abstract Multiple sclerosis has undergone a therapeutic revolution over the past three decades. Randomized clinical trials and real‐world data demonstrate that modern disease‐modifying therapies substantially reduce relapse rates and acute inflammatory activity detected by magnetic resonance imaging (MRI).
Fredrik Piehl, Gonçalo Castelo‐Branco, Maja Jagodic, Tomas Olsson   +3 more
wiley   +1 more source

Oxysterol undersulfation promotes osteoarthritis by fueling chondrocyte lipid accumulation

Nature Communications
Osteoarthritis (OA) is a common degenerative joint disease with no curative treatments and a poorly understood etiology. Here, we report that defective sulfation, a largely underexplored chemical modification of lipid metabolites, drives pathogenic lipid
Huanbo Wang, Bowei Ni, Yu Qian, Guangyu Ding, Ting He, Xinyu Zhang, Hailun Xu, Xue Hao, Yaqian Hu, Di Wang, Qiang Jie, Ying Li, Tianyang Jie, Zhong Alan Li, Zhuojing Luo, Houfeng Zheng, Liu Yang, Chao Zheng   +17 more
doaj   +1 more source

A novel site comes into sight

eLife, 2013
Oxysterols modulate the Hedgehog signalling pathway by binding a novel site on the membrane protein Smoothened, which may offer new options for the treatment of cancers linked to this pathway.
Yu Wang, Andrew P McMahon
doaj   +1 more source