Results 11 to 20 of about 1,802 (199)

Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis [PDF]

BMJ Open
Introduction Excessive bleeding after childbirth (postpartum haemorrhage, PPH) affects 5% of births and causes 75 000 maternal deaths worldwide annually.
Kerry Woolfall, Ben Hardwick, Dimitrios Siassakos, Andrew Shennan, Stephen Robson, Dyfrig A Hughes, Carrol Gamble, Elizabeth Deja, Andrew Weeks, Peter Collins, Jim Thornton, Kirtana Vallabhaneni, Tina Lavender, Gillian Gyte, Helen Hickey, Egle Saviciute, Anna Rosala-Hallas, Efstathia Gkioni, Kim Hinshaw, Catrin Plumpton, Shireen Meher, Annette L Briley, Rachel E Collis, Charlotte Van Netten, Dilly Anumba, Sion Kenyon, Elaine Willis   +26 more
doaj   +3 more sources

The Effect of Carbetocin on Cardiac Repolarization: A Randomized, Placebo‐ and Positive‐Controlled QT/QTc Study in Healthy Adults [PDF]

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Carbetocin is an oxytocin receptor agonist used for postpartum hemorrhage prevention. While oxytocin is known to transiently prolong the QT/QTc interval, robust QTc data for carbetocin are limited. Carbetocin is known to elevate HR, which can impact QTc analyses; thus, a dose that did not overly elevate HR was important to select.
Daniël M. Jonker, Katie Barletta, Ekaterine Bagci, Kyle Raymond, Philippe Pinton   +4 more
wiley   +2 more sources

Misoprostol in addition to routine treatment of postpartum hemorrhage: A hospital-based randomized-controlled trial in Karachi, Pakistan [PDF]

BMC Pregnancy and Childbirth, 2008
Background Postpartum hemorrhage (PPH) remains a major killer of women worldwide. Standard uterotonic treatments used to control postpartum bleeding do not always work and are not always available. Misoprostol's potential as a treatment option for PPH is
Blum Jennifer, Baber Neelofur, Sikander Rozina, Durocher Jill, Zuberi Nadeem F, Walraven Gijs   +5 more
doaj   +3 more sources

Acute Hemorrhagic Manifestations in a Pregnant Patient With Type 1 von Willebrand Disease: Challenges in Management of Bleeding Disorders During Gestation [PDF]

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT This case reports a primigravida with Type 1 von Willebrand disease experiencing hematuria and gingival bleeding despite prophylaxis. Although pregnancy raises factor levels, her response was insufficient. Desmopressin successfully controlled mucosal hemorrhage, avoiding antifibrinolytics due to obstructive risk.
Jose Luis Rojas‐Oviedo, María Fernanda Leal Walteros, Dauris Lineth Mejía Pérez, Jorge Eliecer Castellanos Corredor, Danna Geraldinne Amaya Sánchez, Ana Sofía Lancheros Ramírez   +5 more
wiley   +2 more sources

When Is Postpartum Haemorrhage Treatment Initiated? A Nested Observational Study Within the E‐MOTIVE Trial [PDF]

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 132, Issue 11, Page 1664-1672, October 2025.
ABSTRACT Objective To compare the frequency and timing of postpartum haemorrhage (PPH) treatment initiation between hospitals implementing the MOTIVE treatment bundle (which consisted of uterine Massage, Oxytocic drugs, Tranexamic acid, IntraVenous fluids and Examination) and those following usual care.
Kristie‐Marie Mammoliti, Fernando Althabe, Christina Easter, Adam Devall, James Martin, Adeosun Love Funmi, Rahmatu Yusuf, Fatima Abubakar, Lolade Christiana Arigbede, JimKelly Mugambi, Polycarp Oyoo, Masumbuko Sambusa, Akwinata Banda, Fawzia Samuels, Sara Willemse, Sibongile Doris Khambule, Hilal Mukhtar Shu'aib, Aminu Ado Wakili, Jenipher Okore, Ard Mwampashi, Mandisa Singata‐Madliki, Edna Arends, Elani Muller, Hadiza Galadanci, Zahida Qureshi, Fadhlun Alwy Al‐Beity, G. Justus Hofmeyr, Sue Fawcus, Neil Moran, George Gwako, Alfred Osoti, Ioannis Gallos, Arri Coomarasamy   +32 more
wiley   +2 more sources

Igniting the spark in six countries to transform the trajectory of postpartum hemorrhage across the globe: An overview of the AMPLI‐PPHI project [PDF]

International Journal of Gynecology &Obstetrics, Volume 172, Issue S2, Page S9-S16, June 2026.
Abstract Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality worldwide, disproportionately affecting women in low‐ and middle‐income countries. Despite updated WHO recommendations and the availability of newer technologies—including heat‐stable carbetocin, tranexamic acid as part of a clinical care bundle, misoprostol, and ...
Elaine Roman
wiley   +2 more sources

Carboprost versus oxytocin for active management of third stage of labour [PDF]

Al Ameen Journal of Medical Sciences, 2016
Background and Objectives: Postpartum haemorrhage is a single largest and leading cause of maternal morbidity and mortality not only in developing countries but also in developed countries.
Ambika S. Patil, Vibhavaree Dadavate, Vidya A. Thobbi   +2 more
doaj   +2 more sources

Assessment of the status of emergency obstetric care services in primary health-care centers in selected local government areas of Rivers State, Nigeria

Journal of Public Health and Primary Care, 2023
Background: Reducing maternal and neonatal mortality and morbidity are major public health concern globally and demands policies and commitments, strategy formulations and implementation and improved health-care service delivery and management.
Ishmael D Jaja, Michael Promise Ogolodom
doaj   +1 more source

Efficacy of B-Lynch compression suture for control of intractable hemorrhage during cesarean section

MGM Journal of Medical Sciences, 2022
Background: Primary postpartum hemorrhage (PPH) due to atonicity during lower segment cesarean section is commonly seen in obstetric practice. Usually, it responds to uterotonics but at times it may lead to life-threatening complications.
Priya Manohar Bagade
doaj   +1 more source

Comparative study of Foley’s catheter and prostaglandin E2 gel for pre-induction cervical ripening

Asian Journal of Medical Sciences, 2022
Background: Induction of labor is a crucial and customary clinical procedure in obstetrics. It is arguably one of the most abused procedures. Cervical ripening determines the success of delivery.
Shruti J Shetty , Spandana J C , Anju Arpana , Chaitra Sathyanarayana   +3 more
doaj   +1 more source