Results 91 to 100 of about 134,018 (351)

Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1

Cell Reports, 2017
Summary: Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which ...
Yelena Nersesyan, Lusine Demirkhanyan, Deny Cabezas-Bratesco, Victoria Oakes, Ricardo Kusuda, Tyler Dawson, Xiaohui Sun, Chike Cao, Alejandro Martin Cohen, Bharath Chelluboina, Krishna Kumar Veeravalli, Katharina Zimmermann, Carmen Domene, Sebastian Brauchi, Eleonora Zakharian   +14 more
doaj  

Click‐Functionalized Cyanine Fluorogenic Dimers for Improved Detection of GPCRs: Application to Imaging of ApelinR in Living Cells

Chemistry – A European Journal, EarlyView.
A click‐mediated functionalization of a cyanine 5.5 bearing a terminal alkyne gave a rapid access to a library of ten new cyanine dyes and their corresponding dimers. A structure‐interaction relationship study led to the identification of an optimal dimer which was conjugated to the apelin‐17 ligand and enabled imaging of ApelinR under no‐wash ...
Océane Florès, Yann Berthomé, Lucille Weiss, Sarah Griesbaum‐Dubourg, Stéphanie Riché, Patrick Wagner, Christel Valencia, Pascal Villa, Andrey S. Klymchenko, Julie Karpenko, Dominique Bonnet   +10 more
wiley   +1 more source

Safety, Tolerability and Pharmacokinetics of Single Doses of Oxytocin Administered via an Inhaled Route in Healthy Females: Randomized, Single-blind, Phase 1 Study

EBioMedicine, 2017
Background: The utility of intramuscular (IM) oxytocin for the prevention of postpartum hemorrhage in resource-poor settings is limited by the requirement for temperature-controlled storage and skilled staff to administer the injection.
Disala Fernando, Sarah Siederer, Sunita Singh, Ian Schneider, Ashutosh Gupta, Marcy Powell, Duncan Richards, Michelle P. McIntosh, Peter Lambert, Susan Fowles   +9 more
doaj   +1 more source

Epigenetic modification of the oxytocin receptor gene is associated with emotion processing in the infant brain [PDF]

, 2019
The neural capacity to discriminate between emotions emerges early in development, though little is known about specific factors that contribute to variability in this vital skill during infancy.
Connelly, J., Grossmann, T., Krol, K., Morris, J., Puglia, M.   +4 more
core   +2 more sources

Synthesis of 2‐(Trifluoromethyl)Azetidines by Strain‐Release Reactions of 2‐(Trifluoromethyl)‐1‐Azabicyclo[1.1.0]Butanes

Chemistry – A European Journal, EarlyView.
2‐(Trifluoromethyl)‐1‐azabicyclo[1.1.0]butanes, available by diastereoselective cyclopropanation of 2‐(trifluoromethyl)‐2H‐azirines, can be successfully involved in strain‐release ring‐opening processes, as illustrated by their reaction with benzyl chloroformate, trifluoroacetic anhydride or palladium‐catalyzed hydrogenolysis.
Anaïs Scuiller, Alexandre Dupas, Gauthier Lefebvre, Naïssa Bouriche, Henri Chédotal, Gérard Guillamot, Janine Cossy, Christophe Meyer   +7 more
wiley   +1 more source

Embodied Precision : Intranasal Oxytocin Modulates Multisensory Integration [PDF]

, 2019
© 2018 Massachusetts Institute of Technology.Multisensory integration processes are fundamental to our sense of self as embodied beings. Bodily illusions, such as the rubber hand illusion (RHI) and the size-weight illusion (SWI), allow us to investigate ...
Aikaterini Fotopoulou, Fairburn C. G., Fairburn C. G., Laura Crucianelli, Lucia Ricciardi, Paul M. Jenkinson, Yannis Paloyelis   +6 more
core   +1 more source

Development of Water‐Soluble 3‐Nitro‐2‐Pyridinesulfenate for Disulfide Bond Formation of Peptide Under Aqueous Conditions

Chemistry – A European Journal, EarlyView.
Highly water‐soluble Npy‐sulfenate functions as an efficient oxidizing agent for the formation of disulfide bonds in thiol‐containing peptides. The Npy‐sulfenate can be used to form a disulfide bond with a thiol‐containing peptide produced by thiol‐additive‐free NCL, thereby facilitating the one‐pot synthesis of adrenomedullin.
Akihiro Taguchi, Megumi Sakata, Ryusei Yamamoto, Hayate Shida, Saeka Kuraishi, Sho Konno, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi   +8 more
wiley   +1 more source

Oxytocin makes us trusting but not gullible [PDF]

, 2009
Originally known for its role in childbirth and lactation, oxytocin (OT) has recently proved to play a key role in social behavior. Deprived of OT, humans are unable to recognize and to bond to their peers.
Anthony Lane, James Gross, Moï, Olivier Luminet, Philippe de Timary   +4 more
core   +1 more source

Anxious to see you: Neuroendocrine mechanisms of social vigilance and anxiety during adolescence. [PDF]

, 2020
Social vigilance is a behavioral strategy commonly used in adverse or changing social environments. In animals, a combination of avoidance and vigilance allows an individual to evade potentially dangerous confrontations while monitoring the social ...
Cassano G. B., Gegenhuber B., Hollingworth S. A., Marler C. A., Park J., Pickett C. L., Williamson C. M.   +6 more
core   +1 more source

Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination”

ChemMedChem, EarlyView.
This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Nancy Cham, Robert P. Doyle
wiley   +1 more source