Results 101 to 110 of about 182,621 (379)

Programmable Site‐Selectivity: pH‐Modulated Triazine–Thiol Exchange for Site‐ and Chemoselective Cysteine Labeling

ChemistryEurope, EarlyView.
A pH‐programmable site‐selective cysteine modification in peptides is reported using a triazine–thiol exchange, termed TriTEx. At acidic pH, internal cysteines are targeted while preserving N‐terminal sites; at neutral pH, N‐terminal cysteines are selectively modified via an irreversible S–N shift.
Katerina Gavriel, Daniel Deißenbeck, Thomas J. Rutjes, Daniëlle W. T. Geers, Jan Meisner, Kevin Neumann   +5 more
wiley   +1 more source

Sex and hormonal status influence the anxiolytic-like effect of oxytocin in mice

Neurobiology of Stress, 2023
Anxiety and depression are highly prevalent psychiatric disorders, affecting approximately 18% of the United States population. Evidence indicates that central oxytocin mediates social cognition, social bonding, and social anxiety.
Khalin E. Nisbett, Luis A. Gonzalez, Marina Teruel, C. Sue Carter, Leandro F. Vendruscolo, Michael E. Ragozzino, George F. Koob   +6 more
doaj  

Emergent synchronous bursting of oxytocin neuronal network. [PDF]

PLoS Computational Biology, 2008
When young suckle, they are rewarded intermittently with a let-down of milk that results from reflex secretion of the hormone oxytocin; without oxytocin, newly born young will die unless they are fostered.
Enrico Rossoni, Jianfeng Feng, Brunello Tirozzi, David Brown, Gareth Leng, Françoise Moos   +5 more
doaj   +1 more source

Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes [PDF]

, 2015
Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition.
Aardema, Alves, Arsic, Asselin, Carluccio, Catov, Challis, Chen, Cheng, Cheng, Cheng, Cheng, Cherny, Chu, Crane, D.C. Wathes, D.R.E. Abayasekara, Flynn, Goncalves, Guillou, Herath, Jabbour, Karsch, Kim, Klein, Lamont, Lee, Leung, Lewis, Lunn, M. Elmes, Nielsen, Noble, Poyser, Reddy, Rimoldi, Robinson, S. Kirkup, Sharp, Smith, Smith, Thorburn, Villa, Wang, Wathes, Wendell, Whittle, Witkin, Z. Cheng, Zhang   +49 more
core   +1 more source

RAGE regulates oxytocin transport into the brain

Communications Biology, 2020
Oxytocin, a nonapeptide hormone, has a key role in female reproductive functions as well as in social memory in the brain. In our recent Communications Biology article, we reported that oxytocin is transported from the peripheral blood into the brain by ...
Yasuhiko Yamamoto, H. Higashida
semanticscholar   +1 more source

Oxytocin and Self-Consciousness [PDF]

Frontiers in Human Neuroscience, 2016
In recent years, the study of self-consciousness from neuroscience and psychobiological perspectives has flourished rapidly. The understanding of the brain areas involved in self-consciousness and the complex intertwining of self-consciousness levels has expanded greatly, and the awareness of neurotransmitter influence on self-consciousness has begun ...
Valentina eColonnello, Markus eHeinrichs, Markus eHeinrichs   +2 more
openaire   +5 more sources

First‐in‐Human Study of Merotocin, a Short‐Acting Peptidic Oxytocin Receptor Agonist for Lactation Support

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Endogenous oxytocin plays an important role in lactation, but its effectiveness as an exogenous galactagogue has been modest due to dose‐limiting side effects related to off‐target effects at the vasopressin V2 receptor. Merotocin (FE 202767) is a short‐acting peptidic oxytocin receptor agonist with the potential to aid mothers experiencing ...
Yu Bagger, Carina Holmqvist, Daniël M. Jonker, Bjarke M. Klein, Lorien E. Urban   +4 more
wiley   +1 more source

The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes

International Journal of Cancer, EarlyView.
What's New? The rarity of acute lymphoblastic leukaemia and lack of available environmental data have made the role of environmental factors in genetic subtypes challenging to investigate. Here, the authors performed a CpG‐level analysis to investigate DNA methylation as an intermediate mechanism between environmental risk exposures and acute ...
Jessica R. Saville, Lisa J. Russell, Kay Padget, Akram Ghantous, Jessica Nordlund, Jill A. McKay   +5 more
wiley   +1 more source

The biopsychology of maternal behavior in nonhuman mammals [PDF]

, 1990
The term “maternal behavior,” when applied to nonhuman mammals, includes the behaviors exhibited in preparation for the arrival of newborn, in the care and protection of the newly arrived young, and in the weaning of those young, and represents a complex
Kristal, Dr. Mark B.
core  

Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells, without modifying intracellular calcium transients [PDF]

, 1993
Glucocorticoid hormones suppress the secretion of ACTH evoked by secretagogues such as CRF and arginine vasopressin. In this study, we investigated the effects of glucocorticoids on ACTH release induced by oxytocin (OT) and on intracellular free calcium ...
Dayanithi, G., Gratzl, Manfred, Link, H.
core   +1 more source