Results 161 to 170 of about 45,357 (250)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen   +2 more
wiley   +1 more source

Maternity Care Providers Perspectives and Experiences of Obstetric Violence in Low‐, Middle‐ and High‐Income Countries: An Integrative Review

open access: yesJournal of Advanced Nursing, Volume 82, Issue 4, Page 2790-2809, April 2026.
ABSTRACT Aim To explore the perspectives and experiences of maternity care providers regarding obstetric violence across low‐, middle‐, and high‐income countries. Design An integrative review of the literature. Methods A systematic literature search in CINAHL, Medline (via Ovid), SCOPUS, and the Cochrane Library was conducted from 2014 to 2024. Further
Emma C. Collins   +3 more
wiley   +1 more source

Heartfelt intervention: A role for PVN oxytocin neurons in the prediabetic heart

open access: yes
The Journal of Physiology, EarlyView.
Grace K. Nielsen   +2 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

open access: yesAging and Cancer, Volume 7, Issue 1, Page 21-31, March 2026.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

open access: yesAdvanced Science, Volume 13, Issue 17, 23 March 2026.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao   +8 more
wiley   +1 more source

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