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Regulation of Oxytocin Receptors and Oxytocin Receptor Signaling
Seminars in Reproductive Medicine, 2007The oxytocin (OT) -oxytocin receptor (OTR) system plays a key role in many aspects of mammalian reproduction as well as several other physiological processes such as bond pairing and cardiovascular homeostasis. To manifest these diverse physiological roles, the transcription and expression of the OTR is tightly regulated within reproductive ...
Andrew Blanks, Anatoliy Shmygol
exaly +3 more sources
A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling
Neuropharmacology, 2019Oxytocin mediates its behavioural effects via the centrally expressed oxytocin receptor (OTR). Oxytocin signalling has been implicated in multiple disorders involving centrally regulated pathways, including obesity, autism, schizophrenia and depression.
Ruben García-Cabrerizo, John Cryan
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Trends in Endocrinology & Metabolism, 2003
Novel sites of oxytocin receptor expression have recently been detected, including breast cancer cells, bone cells, myoblasts, cardiomyocytes and endothelial cells. These discoveries have greatly expanded the possible spectrum of oxytocin action beyond its classic role as an inducer of uterine contractions and milk ejection.
Hans H, Zingg, Stephane A, Laporte
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Novel sites of oxytocin receptor expression have recently been detected, including breast cancer cells, bone cells, myoblasts, cardiomyocytes and endothelial cells. These discoveries have greatly expanded the possible spectrum of oxytocin action beyond its classic role as an inducer of uterine contractions and milk ejection.
Hans H, Zingg, Stephane A, Laporte
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Oxytocin-induced desensitization of the oxytocin receptor
American Journal of Obstetrics and Gynecology, 2003The purpose of this study was to characterize the oxytocin-induced desensitization of oxytocin-stimulated rises of intracellular calcium in cultured human myocytes.Culture lines were begun from biopsy specimens of myometrium that had been obtained from women who underwent low transverse cesarean deliveries.
Christopher, Robinson +3 more
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Oxytocin and Oxytocin Receptors in Cancer Cells and Proliferation
Journal of Neuroendocrinology, 2004AbstractThe hypothalamic nonapeptide oxytocin plays a crucial role in many reproductive and behavioural functions. However, in recent years, an additional new role for oxytocin has been identified in neoplastic pathology. In tumours, oxytocin acts as a growth regulator, through the activation of a specific G‐coupled transmembrane receptor, the oxytocin
Cassoni P +4 more
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1999
The oxytocin receptor was first identified using a pharmacological ligandbinding assay in the rat myometrium (Soloff and Swartz 1973). Its peptide ligand, oxytocin, belongs to the nonapeptide hormone family comprising both oxytocin-like (mesotocin, isotocin, etc.) and vasopressin-like (vasotocin, phenypressin, etc.) cyclic peptides.
T, Kimura, R, Ivell
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The oxytocin receptor was first identified using a pharmacological ligandbinding assay in the rat myometrium (Soloff and Swartz 1973). Its peptide ligand, oxytocin, belongs to the nonapeptide hormone family comprising both oxytocin-like (mesotocin, isotocin, etc.) and vasopressin-like (vasotocin, phenypressin, etc.) cyclic peptides.
T, Kimura, R, Ivell
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Oxytocin, oxytocin-associated neurophysin and the oxytocin receptor in the human prostate
Cell and Tissue Research, 2004Oxytocin has been implicated in the regulation of prostate growth. However, the cellular localisation of oxytocin in the normal and diseased human prostate is not known. Oxytocin, oxytocin-associated neurophysin and oxytocin receptor were detected by immunohistochemistry in tissues from patients undergoing routine prostatectomy and in normal human ...
Whittington, K +3 more
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