Results 221 to 230 of about 23,245 (263)
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Vasopressin and oxytocin receptors
Baillière's Clinical Endocrinology and Metabolism, 1996The oxytocin and the vasopressin V1a, V1b and V2 receptors have recently been cloned and shown to form a sub-family within the large superfamily of G-protein-linked receptors. Renal V2 receptors mediate vasopressin-induced water reabsorption via induction of intracellular cAMP production in collecting duct cells.
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2008
The great diversity of the expression sites and proposed function of the oxytocin (OXT) receptor (OXTR) is paralleled by a diversity of its signalling pathways, many of which have still remained unexplored. We have used different approaches to discover novel pathways.
Dominic, Devost +2 more
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The great diversity of the expression sites and proposed function of the oxytocin (OXT) receptor (OXTR) is paralleled by a diversity of its signalling pathways, many of which have still remained unexplored. We have used different approaches to discover novel pathways.
Dominic, Devost +2 more
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Oxytocin Receptor Antagonists: Update
Clinics in Perinatology, 1998For over three decades, scientists in a number of different laboratories have worked to design peptide analogues of oxytocin (OT) selective for the oxytocin receptor. Although there has been some interest in their use for treatment of dysmenorrhea, the principal clinical venue for such agents has been thought to lie in treatment of preterm labor.
T M, Goodwin, A, Zograbyan
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Oxytocin and Oxytocin Receptor Gene Expression in the Uterus
1995Publisher Summary The posterior pituitary contains a strong uterotonic activity known as the nonapeptide oxytocin (OT). It has been determined that uterus itself represents a major site of OT production. Therefore, the activation of uterine contractions by circulating OT is only one aspect of OT action. A significant portion of OT activity originates
H H, Zingg +6 more
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Oxytocin Receptors in Human Uterus*
The Journal of Clinical Endocrinology & Metabolism, 1974ABSTRACT [3H]oxytocin ([3H]OT) was bound in vitro to the 20,000 × g particulate fraction prepared from the myometrium of 2 women, 14–16 weeks pregnant. The apparent dissociation constants for oxytocin binding in preparations of the two uteri were 1.99 ± 0.18 (se) × 10−9 m (n = 9) and 2.81 ± 0.26 × 10−9 m (n = 10), respectively.
M S, Soloff, T L, Swartz, A H, Steinberg
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Oxytocin Antagonist (dTVT) and Oxytocin Receptors in Myometrium and Decidua
American Journal of Perinatology, 1989To investigate whether a putative oxytocin (OT) receptor blocker 1-deamino-[2-D-tyrosine (OEt)-4 threonine-8-ornithine]oxytocin (dTVT) inhibits OT binding to its receptors, we studied binding of [3H]OT to late-pregnant human, guinea pig, and rat myometrial and decidual membranes and competition of dTVT with this binding.
A R, Fuchs +3 more
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Molecular evolution of the oxytocin–oxytocin receptor system in eutherians
Molecular Phylogenetics and Evolution, 2013Oxytocin (OXT) is a nine-amino-acid peptide hormone that is mainly released at the times of uterine contractions during parturition and milk ejection during lactation, whereas a similar peptide hormone, arginine vasopressin, primarily exerts direct antidiuretic action on the kidney and causes vasoconstriction of the peripheral vessels. The genes coding
Kaoru, Yamashita, Takashi, Kitano
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Oxytocin receptors in rat oviduct
Biochemical and Biophysical Research Communications, 1975The binding of tritiated oxytocin was studied in rat oviduct homogen ates sedimenting between 1000 X g for 10 minutes and 48000 X g for 30 minutes. Results showed that oxytocin is specifically bound to oviducal particles with high affinity. In particles prepared from estrogen-treated rats apparent Kd for oxytocin binding was 1.8 X 10 M.
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European Journal of Pharmacology, 2005
We have analyzed binding domains of the oxytocin receptor for barusiban, a highly selective oxytocin receptor antagonist, in comparison to the combined vasopressin V1A/oxytocin receptor antagonist atosiban and the agonists oxytocin and carbetocin. For this purpose, chimeric 'gain-in function' oxytocin/vasopressin V2 receptors were expressed in COS-7 ...
Gerald, Gimpl +3 more
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We have analyzed binding domains of the oxytocin receptor for barusiban, a highly selective oxytocin receptor antagonist, in comparison to the combined vasopressin V1A/oxytocin receptor antagonist atosiban and the agonists oxytocin and carbetocin. For this purpose, chimeric 'gain-in function' oxytocin/vasopressin V2 receptors were expressed in COS-7 ...
Gerald, Gimpl +3 more
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Journal of Neuroendocrinology, 2003
AbstractIn the female rat, oestrogen receptor (ER) β is colocalized with both oxytocin‐ and vasopressin‐producing neurones in the paraventricular nucleus of the hypothalamus (PVN). In this study, we demonstrate that the same pattern of colocalization between ERβ and oxytocin exists in the female mouse.
H B, Patisaul +3 more
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AbstractIn the female rat, oestrogen receptor (ER) β is colocalized with both oxytocin‐ and vasopressin‐producing neurones in the paraventricular nucleus of the hypothalamus (PVN). In this study, we demonstrate that the same pattern of colocalization between ERβ and oxytocin exists in the female mouse.
H B, Patisaul +3 more
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