Results 261 to 270 of about 24,748 (316)
Some of the next articles are maybe not open access.
Regulation of Oxytocin Receptors and Oxytocin Receptor Signaling
Seminars in Reproductive Medicine, 2007The oxytocin (OT) -oxytocin receptor (OTR) system plays a key role in many aspects of mammalian reproduction as well as several other physiological processes such as bond pairing and cardiovascular homeostasis. To manifest these diverse physiological roles, the transcription and expression of the OTR is tightly regulated within reproductive ...
Andrew M, Blanks +2 more
openaire +2 more sources
Oxytocin Receptor Antagonists: Update
Clinics in Perinatology, 1998For over three decades, scientists in a number of different laboratories have worked to design peptide analogues of oxytocin (OT) selective for the oxytocin receptor. Although there has been some interest in their use for treatment of dysmenorrhea, the principal clinical venue for such agents has been thought to lie in treatment of preterm labor.
T M, Goodwin, A, Zograbyan
openaire +2 more sources
Oxytocin-induced desensitization of the oxytocin receptor
American Journal of Obstetrics and Gynecology, 2003The purpose of this study was to characterize the oxytocin-induced desensitization of oxytocin-stimulated rises of intracellular calcium in cultured human myocytes.Culture lines were begun from biopsy specimens of myometrium that had been obtained from women who underwent low transverse cesarean deliveries.
Christopher, Robinson +3 more
openaire +2 more sources
A ghrelin receptor and oxytocin receptor heterocomplex impairs oxytocin mediated signalling
Neuropharmacology, 2019Oxytocin mediates its behavioural effects via the centrally expressed oxytocin receptor (OTR). Oxytocin signalling has been implicated in multiple disorders involving centrally regulated pathways, including obesity, autism, schizophrenia and depression.
Shauna E. Wallace Fitzsimons +7 more
openaire +2 more sources
2008
The great diversity of the expression sites and proposed function of the oxytocin (OXT) receptor (OXTR) is paralleled by a diversity of its signalling pathways, many of which have still remained unexplored. We have used different approaches to discover novel pathways.
Dominic, Devost +2 more
openaire +2 more sources
The great diversity of the expression sites and proposed function of the oxytocin (OXT) receptor (OXTR) is paralleled by a diversity of its signalling pathways, many of which have still remained unexplored. We have used different approaches to discover novel pathways.
Dominic, Devost +2 more
openaire +2 more sources
1999
The oxytocin receptor was first identified using a pharmacological ligandbinding assay in the rat myometrium (Soloff and Swartz 1973). Its peptide ligand, oxytocin, belongs to the nonapeptide hormone family comprising both oxytocin-like (mesotocin, isotocin, etc.) and vasopressin-like (vasotocin, phenypressin, etc.) cyclic peptides.
T, Kimura, R, Ivell
openaire +2 more sources
The oxytocin receptor was first identified using a pharmacological ligandbinding assay in the rat myometrium (Soloff and Swartz 1973). Its peptide ligand, oxytocin, belongs to the nonapeptide hormone family comprising both oxytocin-like (mesotocin, isotocin, etc.) and vasopressin-like (vasotocin, phenypressin, etc.) cyclic peptides.
T, Kimura, R, Ivell
openaire +2 more sources
Vasopressin and oxytocin receptors
Baillière's Clinical Endocrinology and Metabolism, 1996The oxytocin and the vasopressin V1a, V1b and V2 receptors have recently been cloned and shown to form a sub-family within the large superfamily of G-protein-linked receptors. Renal V2 receptors mediate vasopressin-induced water reabsorption via induction of intracellular cAMP production in collecting duct cells.
openaire +3 more sources
Oxytocin and Oxytocin Receptors in Cancer Cells and Proliferation
Journal of Neuroendocrinology, 2004AbstractThe hypothalamic nonapeptide oxytocin plays a crucial role in many reproductive and behavioural functions. However, in recent years, an additional new role for oxytocin has been identified in neoplastic pathology. In tumours, oxytocin acts as a growth regulator, through the activation of a specific G‐coupled transmembrane receptor, the oxytocin
CASSONI, Paola +4 more
openaire +4 more sources
Oxytocin Receptors in Human Uterus*
The Journal of Clinical Endocrinology & Metabolism, 1974ABSTRACT [3H]oxytocin ([3H]OT) was bound in vitro to the 20,000 × g particulate fraction prepared from the myometrium of 2 women, 14–16 weeks pregnant. The apparent dissociation constants for oxytocin binding in preparations of the two uteri were 1.99 ± 0.18 (se) × 10−9 m (n = 9) and 2.81 ± 0.26 × 10−9 m (n = 10), respectively.
M S, Soloff, T L, Swartz, A H, Steinberg
openaire +2 more sources
Human osteoclasts express oxytocin receptor
Biochemical and Biophysical Research Communications, 2002Increasing evidences demonstrated many new targets for the hypothalamic hormone oxytocin, as the regulation of food balance and in some cases of leptin secretion. Considering that leptin is a potent inhibitor of bone formation and that oxytocin receptors (OTR) were detected in normal human osteoblasts, we investigated if OTR was expressed by human ...
COLUCCI, Silvia Concetta +4 more
openaire +2 more sources