Results 61 to 70 of about 2,710 (195)

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, Volume 4, Issue 1, March 2026.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Extramacular Retinal Hole Following Intravitreal Dexamethasone Implant: Case Report

Türk Oftalmoloji Dergisi, 2019
The intravitreal dexamethasone implant Ozurdex is indicated for the treatment of macular edema due to diabetes and branch retinal vein occlusion. While the most common ocular side effects are elevated intraocular pressure and cataract formation, rare ...
Cansu Ekinci, Alp Kayıran, Hakan Özdemir   +2 more
doaj   +1 more source

Reflux hyphema from transient hypotony after Ozurdex® in eyes with prior GATT [PDF]

, 2023
Purpose: To report on delayed-onset hyphema following intravitreal injection of dexamethasone implant Ozurdex® in eyes with a history of gonioscopy-assisted transluminal trabeculotomy (GATT).
Mary Qiu, Jason Xiao, Tanenbaum, Rebecca E., Xiao, Jason, Qiu, Mary, Rebecca E. Tanenbaum   +5 more
core   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source

The Efficacy of Single-Dose Intravitreal Dexamethasone Implant for Diabetic Macular Edema Refractory to Anti-VEGF Therapy: Real-Life Results

Beyoglu Eye Journal, 2020
INTRODUCTION[|]To investigate the efficacy, safety, and side effect profiles of a single-dose intravitreal dexamethasone implant (IDI, Ozurdex) in patients with diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (VEGF ...
Mert Simsek, Mehmet Citirik, Serdar Ozates, Kemal Tekin, Dilara Ozkoyuncu   +4 more
doaj   +1 more source

Short-Term Outcomes of Refractory Diabetic Macular Edema Switch From Ranibizumab to Dexamethasone Implant and the Influential Factors: A Retrospective Real World Experience

Frontiers in Medicine, 2021
Introduction: To evaluate the effectiveness and safety of intravitreal dexamethasone (DEX) implants in refractory diabetic macular edema (DME) treated by intravitreal ranibizumab.Materials and Methods: We retrospectively analyzed DME patients who ...
Ning-Yi Hsia, Chun-Ju Lin, Chun-Ju Lin, Chun-Ju Lin, Huan-Sheng Chen, Cheng-Hsien Chang, Cheng-Hsien Chang, Cheng-Hsien Chang, Henry Bair, Henry Bair, Chun-Ting Lai, Jane-Ming Lin, Jane-Ming Lin, Wen-Lu Chen, Wen-Lu Chen, Peng-Tai Tien, Peng-Tai Tien, Wen-Chuan Wu, Yi-Yu Tsai, Yi-Yu Tsai, Yi-Yu Tsai   +20 more
doaj   +1 more source

Intraoperative Dexamethasone Intravitreal Implant (Ozurdex) in Vitrectomy Surgery for Epiretinal Membrane

, 2019
Objective: To study the effectiveness and safety of the intravitreal dexamethasone implant 0.7 mg (Ozurdex®) in vitrectomy surgery for epiretinal membrane. Methods: This is a prospective, multicenter, pilot study.
Avner Hostovsky (8106461), Drew Mulhall (8106467), Christina Leung (8106470), Rajeev H. Muni (7623494), Peter J. Kertes (8106473), Kenneth T. Eng (8106464)   +5 more
core   +1 more source

Selective Laser Sintering 3D Printing of Drug‐Loaded Intravitreal Implants

Advanced Functional Materials, Volume 36, Issue 4, 12 January 2026.
Selective laser sintering enables the fabrication of biodegradable and biocompatible intravitreal implants with tunable microstructures for sustained drug delivery. By modulating laser scanning speed, the polymer matrix architecture is engineered to control the release kinetics of dexamethasone and riboflavin over several months. This approach offers a
Iria Seoane‐Viaño, Carlos Bendicho‐Lavilla, Haya Alfassam, Bárbara Blanco‐Fernández, Abdul W. Basit, Francisco J. Otero‐Espinar   +5 more
wiley   +1 more source

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer, Lea Skrzypczyk, Sabrina Wohlfart, Bryan Calder Ackermann, Ludwig Geisweid, Simon William Pohl, Margarita Karaivanova, Jonathan Herth, Victor Aristide Augustin, Alexander Studier‐Fischer, Tina Sackmann, Leon Kaulen, Anna Steyer, Walter Mier, David H Steel, Kanmin Xue, Gerd Uwe Auffarth, Philipp Uhl   +17 more
wiley   +1 more source

The application of dexamethasone implants in uveitis treatment

Frontiers in Medicine
Uveitis refers to a group of ocular inflammatory diseases that can significantly impair vision. Although systemic corticosteroid therapy has shown substantial efficacy in treating uveitis, extensive use of corticosteroids is associated with significant ...
Tian Zhang, Zhutao Liu, Na Li
doaj   +1 more source