The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Measuring digital transformation in high-end equipment manufacturing: an I-P-O model-based approach. [PDF]
Chen Y, Huang J, Li Y.
europepmc +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Synthesis of Symmetrical Silane Containing P=O Bonds and Their Passivation of Perovskites. [PDF]
Dai B +10 more
europepmc +1 more source
Plasmon-Controlled Selective Emission Enhancement of Eu3+ with (Au Core)@(Y(V,P)O4:Eu) Nanostructures. [PDF]
Zhang J +4 more
europepmc +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
2,5-Dihydroxy-1,4-benzoquinones Appended with -P(O)(OR)<sub>2</sub> (R = Me or Et) Groups and Their Ammonium and Lithium Salts: Structural, Spectroscopic, and Electrochemical Properties. [PDF]
Kearney CA +8 more
europepmc +1 more source
Growth of binary anatase-rutile on phosphorylated graphene through strong P-O-Ti bonding affords a stable visible-light photocatalyst. [PDF]
Zirar FE +4 more
europepmc +1 more source
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Interfacial P-O-Cu Bonds Drive Rapid Z-Scheme Charge Transfer for Efficient Photocatalytic O<sub>2</sub> Evolution Synchronized with Cr(VI) Reduction. [PDF]
Wei Y, Su Z, Weng B.
europepmc +1 more source

