Results 161 to 170 of about 4,045,904 (231)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Unraveling the Mechanism and Influence of Auxiliary Ligands on the Isomerization of Neutral [P,O]-Chelated Nickel Complexes for Olefin Polymerization. [PDF]

J Org Chem
Tan J, Liu J, Zhang X.
europepmc   +1 more source

Nickel and Copper Catalyzed ipso-Phosphonodifluoromethylation of Arylboronic Acids with BrCF₂ P(O)(OEt)₂ for the Synthesis of Phosphonodifluoromethylarenes. [PDF]

Chemistry, 2022
Knieb A, Krishnamurti V, Ispizua-Rodriguez X, Surya Prakash GK.   +3 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

New Insights into the Key Role of Thermal Treatment in V/P/O Catalysts for the Selective Oxidation of n-Butane to Maleic Anhydride. [PDF]

ACS Omega
Conte L, Setti L, Luzzati G, Tabanelli T, Fratalocchi L, Grazia L, Luciani S, Bordoni S, Cortelli C, Cavani F.   +9 more
europepmc   +1 more source

Boronate Covalent and Hybrid Organic Frameworks Featuring P^III and P=O Lewis Base Sites. [PDF]

Chemistry, 2020
Pacholak P, Gontarczyk K, Kamiński R, Durka K, Luliński S.   +4 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Efforts to Address the Burden of Non-Communicable Diseases Need Local Evidence and Shared Lessons from High-Burden Countries

Annals of Global Health, 2023
Jackline E. Ngowi, Castory Munishi, Harrieth P. Ndumwa, Belinda J. Njiro, Davis E. Amani, Erick A. Mboya, Doreen Mloka, Amani I. Kikula, Emmanuel Balandya, Paschal Ruggajo, Anna T. Kessy, Emilia Kitambala, Ntuli Kapologwe, James T. Kengia, James Kiologwe, Omary Ubuguyu, Bakari Salum, Appolinary Kamuhabwa, Kaushik Ramaiya, Bruno F. Sunguya   +19 more
doaj   +1 more source

High-Efficiency Light Emitters: 10-(Diphenylphosphoryl)-anthracenes from One-Pot Synthesis Including C-O-P to C-P(═O) Rearrangement. [PDF]

J Org Chem
Vivek V, Koprowski M, Różycka-Sokołowska E, Turek M, Dudziński B, Owsianik K, Knopik Ł, Bałczewski P.   +7 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source