Results 161 to 170 of about 29,522,340 (290)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

[Report to W. P. Gannaway by O. J. Tarver and L. D. Stringfellow, February 17, 1964 #4]

open access: yes, 1964
Intelligence Report by O. J. Tarver to Captain W. P. Gannaway, through Lieutenant Jack Revill. The report is concerning an interview with Madie Bell Reese, an employee of the Texas School Book Depository who stated that she did not know Lee Harvey ...
Tarver, O. J.
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

AVALIAÃÃO DA EFICIÃNCIA DE FOSSA SÃPTICA DE BAIXO CUSTO DESENVOLVIDA PARA O SANEAMENTO RURAL

open access: yes, 2018
O tratamento do esgoto sanitário é essencial para a vida saudável, à proteção da biodiversidade, à recuperação e manutenção dos recursos ambientais.
Bressane, Adriano; Universidade Estadual Paulista - UNESP; adrianobressane@ymail.com   +3 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

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