Results 181 to 190 of about 844,522 (250)

The impact of CB-153 and p,p’-DDE on androgen receptor function

, 2009
Björk, C, Nenonen, H, Giwercman, Alexander, Bergman, Åke, Rylander, Lars, Lundberg Giwercman, Yvonne   +5 more
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Metabolic effects of p,p′‐DDE on Atlantic salmon hepatocytes

Journal of Applied Toxicology, 2017
AbstractDecades after being banned in many countries, DDT and its metabolites are still considered major environmental hazards. The p,p′‐DDE isomer, the DDT metabolite found in highest concentration in aquaculture feeds, is an endocrine disruptor with demonstrated ability to induce epigenetic effects.
Pål A. Olsvik, Liv Søfteland
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Persistent DDT metabolite p,p'–DDE is a potent androgen receptor antagonist

Nature, 1995
The increase in the number of reports of abnormalities in male sex development in wildlife and humans coincided with the introduction of 'oestrogenic' chemicals such as DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) into the environment. Although these phenotypic alterations are thought to be mediated by the oestrogen receptor, they are also ...
W R, Kelce, C R, Stone, S C, Laws, L E, Gray, J A, Kemppainen, E M, Wilson   +5 more
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Induction of hepatic aromatase by p,p′-DDE in adult male rats

Molecular and Cellular Endocrinology, 2001
1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE, DDE) is a stable metabolite of the pesticide DDT and a persistent environmental pollutant. Earlier reports have demonstrated that DDE is an endocrine-active compound capable of affecting early-stage sexual differentiation in male rats.
L, You, M, Sar, E, Bartolucci, S, Ploch, M, Whitt   +4 more
exaly   +3 more sources

Endocrine disruption effects of p,p′‐DDE on juvenile zebrafish

Journal of Applied Toxicology, 2014
AbstractThe persistent organic pollutant p,p′‐DDE, the major metabolite of the insecticide DDT, has displayed evidence of endocrine disruption through the inhibition of androgen binding to androgen receptors in different species. Although p,p′‐DDE was continuously detected in wild fish with abnormal gonad development such as intersex, little is known ...
Monteiro, Marta Sofia, Pavlaki, Maria, Faustino, Augusto, Rêma, Alexandra, Franchi, Mariana, Gediel, Letícia, Loureiro, Susana, Domingues, Inês, von Osten, Jaime Rendón, Velho Maia Soares, Amadeu Mortágua   +9 more
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Polychlorobiphenyl congeners,p,p?-DDE, and sperm function in humans

Archives of Environmental Contamination and Toxicology, 1986
170 seminal samples from fertile men, men with idiopathic oligospermia or azoospermia and men status post vasectomy were analyzed for 74 polychlorobiphenyl (PCB) congeners,p,p′-DDE, mirex, and hexachlorobenzene using the technique of glass capillary gas chromatography with electron capture detection. Low concentrations of 32 PCB congeners were measured
B, Bush, A H, Bennett, J T, Snow
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p,p′-DDE depresses the immune competence of chinook salmon (Oncorhynchus tshawytscha) leukocytes

Fish and Shellfish Immunology, 2005
p,p'-DDE, the main metabolite of DDT, is still detected in aquatic environments throughout the world. Here, the effects and mechanisms by which p,p'-DDE exposure might affect the immune system of chinook salmon (Oncorhynchus tshawytscha) was studied. Isolated salmon splenic and pronephric leukocytes were incubated with different concentrations of p,p ...
Ichiro Misumi
exaly   +3 more sources

In vitro exposure to the organochlorine p,p′-DDE affects functional human sperm parameters

Chemosphere, 2015
Although no information exists regarding the levels of p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) on reproductive fluids of heavily exposed populations, they are possibly quite high given the serum levels reported so far. In these populations altered semen quality has been reported, although the direct effects of this DDT metabolite on crucial ...
Renata S, Tavares, Sandra, Amaral, Carla, Paiva, Marta, Baptista, João, Ramalho-Santos   +4 more
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Comparative thyroid disruption by o,p’-DDT and p,p’-DDE in zebrafish embryos/larvae

Aquatic Toxicology, 2019
1,1-Trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl) ethane (o,p'-DDT) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) cause thyroid disruption, but the underlying mechanisms of these disturbances in fish remain unclear.
Huijun Ru, Zhaohui Ni, He Zhang
exaly   +2 more sources

Differential bioavailability of field-weathered p,p′-DDE to plants of the Cucurbita and Cucumis genera

Chemosphere, 2002
Field experiments were conducted to assess the bioavailability of weathered p,p'-DDE in soil to plants in the Cucurbita (squash, pumpkin) and Cucumis (cucumber, melon) genera. As expected, significant variability exists in the uptake of p,p'-DDE between plants of different genera. Root:soil concentration factors, defined as the ratio of p,p'-DDE (ng/g,
J. White
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