Results 181 to 190 of about 471,910 (249)

A Rare Case of Pancreatic Neuroendocrine Tumor with Intraductal Extension in the Dorsal Duct of a Pancreas Divisum. [PDF]

Reports (MDPI)
Crucillà S, Berlato A, Crinò SF, Landoni L, Conti Bellocchi MC.   +4 more
europepmc   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

A Systematic Review of Deep Learning Approaches for Hepatopancreatic Tumor Segmentation. [PDF]

J Imaging
Hussain R, Mohsin M, Khan D, Zohaib M.
europepmc   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Abdominal foreign body after subtotal pancreatectomy: a case series. [PDF]

J Surg Case Rep
Perez-de-Villar JM, Kunzler F, Hechavarria V, Jimenez RE, Asbun D, Asbun HJ.   +5 more
europepmc   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Type I neurofibromatosis with a solid pseudopapillary neoplasm of the pancreas: a case report and literature review. [PDF]

Discov Oncol
Yang Y, Zhang F.
europepmc   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions. [PDF]

Nat Metab
Radyk MD, Nelson BS, Ruckert MT, Halbrook CJ, Shan M, Alektiar JM, Lavoie BL, Salvatore L, Yan W, Perricone MD, Buscher K, Wood A, Hong HS, Sajjakulnukit P, Zhang L, Corfas G, Bednar F, Frankel TL, Pasca di Magliano M, Colacino JA, Shah YM, Crawford HC, Lyssiotis CA.   +22 more
europepmc   +1 more source

Correlación entre el diagnostico preoperatorio Bioquímica e Imagenólogicamente, frente a hallazgos Quirúrgicos y/o Endoscópicos en pacientes con Ictericia Obstructiva en el Hospital Regional Tlalnepantla ISSEMyM PPS [PDF]

, 2014
Cázares Montañez, Jaime Eduardo, Trujillo Velázquez, Luis Reynaldo   +1 more
core