Results 201 to 210 of about 471,910 (249)

Detección de mutaciones en oncogenes: aplicaciones diagnósticas y pronósticas [PDF]

, 1996
Capellá, Gabriel, Lluís, Félix, Mora, Josefina, Peinado, Miguel Ángel, Reyes, Germán, Villanueva, Alberto   +5 more
core  

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Fatty pancreas: Current insights and future perspectives. [PDF]

World J Methodol
Okasha HH, Alyouzbaki AZ, Tehami N, Abdellatef A.   +3 more
europepmc   +1 more source

Estudio ecográfico de enfermedad pancreática en perros y gatos [PDF]

, 2004
Espada, Yvonne, Novellas Torroja, Rosa
core  

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas. [PDF]

Nat Metab
Hennequart M, Mervant L, Stockis J, Coomes J, Zarou MM, Gerard L, Tevel V, Migeot V, Pilley SE, Lee Y, Driscoll PC, Legrave NM, Labuschagne CF, Zani F, Uribe AH, Ferreira RMM, Cheung EC, Malanchi I, MacRae JI, Maddocks ODK, Halim TYF, Vousden KH.   +21 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Sirolimus Versus Mycophenolate Mofetil in Simultaneous Pancreas-Kidney Transplantation: Impact on Urinary Tract Infection Rates. [PDF]

J Transplant
Píšová B, Chytilová Š, Saudek F, Girman P.   +3 more
europepmc   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Comparative Analysis of Kidney and Simultaneous Pancreas-Kidney Transplantation: Long-Term Outcomes in Type 1 Diabetic Patients with End-Stage Kidney Disease. [PDF]

J Clin Med
Ziaja J, Widera M, Kolonko A, Owczarek AJ, Kamińska D, Świder R, Góral A, Sekta S, Król R, Czerwiński J, Durlik M, Więcek A.   +11 more
europepmc   +1 more source