Results 51 to 60 of about 466,613 (249)

Multiple endocrine neoplasia type 1 in a patient diagnosed with nesidioblastosis. A case presentation

Medisur, 2023
Multiple endocrine neoplasias encompass a series of syndromes characterized by their genetic origin and the involvement of one or more glands. A 23-years-old male patient with a health history of nesidioblastosis diagnosed at 16 years of age, who ...
Olivia Elizabeth Altamirano Guerrero, María Gabriela Balarezo García, Juan Sebastián Lima Icaza   +2 more
doaj  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

10 años de experiencia de pancreaticoduodenectomias en el Hospital Metropolitano de Quito [PDF]

, 2009
Background: Since the 1990’s, pancreaticoduodenectomy has become a surgical procedure employed in a diversity of pathologies of the periampullar region.
Maldonado Villalba, Sofía Gabriela
core  

Acute gastric dilatation in a bulimic patient: Systemic effects [PDF]

, 2012
Objetivos: Mostrar mediante un caso clínico, la repercusión sistémica y las complicaciones orgánicas, que pueden darse tras una dilatación gástrica aguda, ocasionada por un atracón bulímico.
Badillo, S., Contreras, Julio P., Franco-López, Ángeles   +2 more
core   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A propósito de un caso : paciente con cuadro de disartria de una hora y media de evolución [PDF]

, 2017
Insulinoma is a neoplasia of pancreatic β-cells that secretes insulin. It constitutes a rare cause of hypoglycemia. Poor knowledge of this disease is explained by the low incidence, 4 in 1 million people per year. The nonspecific symptoms and its size
Roldán Vásquez, Ana María
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Insulin-like Growth Factor Binding Proteins and Cellular Senescence Are Involved in the Progression of Non-Alcoholic Fatty Liver Disease and Fibrosis in a Mouse Model

Medicina
Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. It progresses from simple steatosis to non-alcoholic steatohepatitis (NASH).
Carolina Guzmán, Miriam G. Bautista-Ubaldo, Adriana Campos-Espinosa, Ivette I. Romero-Bello, Ángel Daniel Santana-Vargas, Gabriela Gutierrez-Reyes   +5 more
doaj   +1 more source

Insulinoma en una hembra adulta de pastor alemán [PDF]

, 2000
Se describe un caso de hipoglucemia persistente en una hembra adulta de Pastor alemán. La historia clínica, exploración directa, bioquímica sérica, ecografía e histopatología permiten establecer un diagnóstico de insulinoma.
Andaluz Martínez, Anna, Espada, Yvonne, García Arnas, Félix, Ruiz de Gopegui i Fernández, Rafael   +3 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source