Results 61 to 70 of about 471,910 (249)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Evaluation of a prebiotic and an organic acid-supplemented diets on the performance and allometric parameters of broiler chickens with controlled feeding [PDF]

open access: yes, 2012
P?ginas 52-66El prop?sito de esta investigaci?n fue evaluar el efecto de un ?cido org?nico (?cido fum?rico), un prebi?tico comercial (Fortifeed?) y la mezcla de estos dos frente a un antibi?tico promotor de crecimiento (Bacitracina de Zn) con ...
Jaramillo, Alvaro H.
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Bovine matrix scaffold implanted in rat liver improve regeneration in a partial hepatectomy model.

open access: yesAnnals of Hepatology
Introduction and objectives: Liver transplant is the recommended therapeutic option for advanced liver damage in chronic liver disease. However, the biocompatibility and low donation rates significantly reduce the chances of performing a successful ...
Moises Martinez-Castillo   +6 more
doaj   +1 more source

Aplicación de la terminología nanda-noc-nic en un paciente trasplantado de páncreas riñón

open access: yesEnfermería Nefrológica, 2016
La Diabetes Mellitus (DM), es una epidemia mundial que se cifra en 190.000.000 de casos, 330.000.000 se prevén en 2025, produce 3.200.000 muertes al año o lo que es lo mismo 6 muertos por minuto.
Consuelo Pérez Rincón   +1 more
doaj   +1 more source

Aparato dixestivo [PDF]

open access: yes, 2013
Titulación: Grao en Farmacia -- Materia: Anatomía, Histoloxía e CitoloxíaO aparato dixestivo é o encargado de transformar os alimentos que inxerimos en sustancias máis sinxelas e facilmente asimilables polo organismo.
Rodríguez Pérez, Ana Isabel
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Estudio del papel de Insulin Degrading Enzyme (IDE) en diabetes mellitus [PDF]

open access: yes, 2016
La diabetes mellitus (DM) es según la OMS una de las pandemias de nuestro siglo. Es urgente la búsqueda de nuevas dianas terapéuticas para la mejora del tratamiento de esta enfermedad y sus complicaciones.
Fernández Luis, Sara   +1 more
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Four years of experience in the use of multidetector computer tomography in pancreas transplantation: a lesson learned together with surgeons [PDF]

open access: yes, 2013
Objetivo. Conocer la anatomía normal posquirúrgica del paciente con trasplante de páncreas en tomografía computada multidetector (TCMD) y describir las complicaciones más frecuentes. Revisión de tema. El trasplante pancreático ha aumentado en los últimos
Gondolesi, Gabriel Eduardo   +5 more
core  

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