Results 61 to 70 of about 449,060 (250)

Collagen matrix scaffold as vehicle of WP1066, STAT-3 inhibitors, in an in vitro hepatocellular model.

Annals of Hepatology
Introduction and objectives: Liver disease causes approximately 1.75 million deaths per year and chronic liver disease (CLD) and is usually detected in advanced stages (cirrhosis or hepatocellular carcinoma) that require partial ablation or transplant ...
Moises Martinez-Castillo, Cristina Piña-Barba, Israel A. Núñez-Tapia, Marisela Hernandez-Santillan, Abigail Hernández-Barragán, Gabriela Gutiérrez-Reyes   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Insulin-like Growth Factor Binding Proteins and Cellular Senescence Are Involved in the Progression of Non-Alcoholic Fatty Liver Disease and Fibrosis in a Mouse Model

Medicina
Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. It progresses from simple steatosis to non-alcoholic steatohepatitis (NASH).
Carolina Guzmán, Miriam G. Bautista-Ubaldo, Adriana Campos-Espinosa, Ivette I. Romero-Bello, Ángel Daniel Santana-Vargas, Gabriela Gutierrez-Reyes   +5 more
doaj   +1 more source

Trasplante de páncreas tipos, selección de receptores y donantes

, 2010
ResumenEn este artículo se describe el estado actual del trasplante de páncreas, los tipos de trasplante más frecuentes –trasplante de páncreas aislado, trasplante de páncreas riñón– sus indicaciones, resultados y las características de receptores y ...
Carlos Zehnder, B., Dr. B. Carlos Zehnder   +1 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Análisis de supervivencia de los pacientes con diagnóstico de cáncer de páncreas tratados en el Hospital Oncológico Solón Espinosa Ayala 2000 – 2015

, 2017
El cáncer se ha convertido en una de las fundamentales causas de mortalidad en todo el mundo. Los países de ingresos medios y bajos registran aproximadamente el 70% de las muertes por esta enfermedad. En general menos del 30% de países con ingresos bajos
Delgado Chasiluisa, María Belén
core   +1 more source

Bovine matrix scaffold implanted in rat liver improve regeneration in a partial hepatectomy model.

Annals of Hepatology
Introduction and objectives: Liver transplant is the recommended therapeutic option for advanced liver damage in chronic liver disease. However, the biocompatibility and low donation rates significantly reduce the chances of performing a successful ...
Moises Martinez-Castillo, Benjamin León-Mancilla, Gerardo Ramirez-Rico, Marisela Hernandez-Santillan, Abigail Hernández-Barragán, Cristina Piña-Barba, Gabriela Gutiérrez-Reyes   +6 more
doaj   +1 more source

Aplicación de la terminología nanda-noc-nic en un paciente trasplantado de páncreas riñón

Enfermería Nefrológica, 2016
La Diabetes Mellitus (DM), es una epidemia mundial que se cifra en 190.000.000 de casos, 330.000.000 se prevén en 2025, produce 3.200.000 muertes al año o lo que es lo mismo 6 muertos por minuto.
Consuelo Pérez Rincón, Eufemiano Pérez del Río   +1 more
doaj   +1 more source