Results 51 to 60 of about 446,761 (202)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Collagen matrix scaffold as vehicle of WP1066, STAT-3 inhibitors, in an in vitro hepatocellular model.

Annals of Hepatology
Introduction and objectives: Liver disease causes approximately 1.75 million deaths per year and chronic liver disease (CLD) and is usually detected in advanced stages (cirrhosis or hepatocellular carcinoma) that require partial ablation or transplant ...
Moises Martinez-Castillo, Cristina Piña-Barba, Israel A. Núñez-Tapia, Marisela Hernandez-Santillan, Abigail Hernández-Barragán, Gabriela Gutiérrez-Reyes   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Insulin-like Growth Factor Binding Proteins and Cellular Senescence Are Involved in the Progression of Non-Alcoholic Fatty Liver Disease and Fibrosis in a Mouse Model

Medicina
Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. It progresses from simple steatosis to non-alcoholic steatohepatitis (NASH).
Carolina Guzmán, Miriam G. Bautista-Ubaldo, Adriana Campos-Espinosa, Ivette I. Romero-Bello, Ángel Daniel Santana-Vargas, Gabriela Gutierrez-Reyes   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Bovine matrix scaffold implanted in rat liver improve regeneration in a partial hepatectomy model.

Annals of Hepatology
Introduction and objectives: Liver transplant is the recommended therapeutic option for advanced liver damage in chronic liver disease. However, the biocompatibility and low donation rates significantly reduce the chances of performing a successful ...
Moises Martinez-Castillo, Benjamin León-Mancilla, Gerardo Ramirez-Rico, Marisela Hernandez-Santillan, Abigail Hernández-Barragán, Cristina Piña-Barba, Gabriela Gutiérrez-Reyes   +6 more
doaj   +1 more source

Aplicación de la terminología nanda-noc-nic en un paciente trasplantado de páncreas riñón

Enfermería Nefrológica, 2016
La Diabetes Mellitus (DM), es una epidemia mundial que se cifra en 190.000.000 de casos, 330.000.000 se prevén en 2025, produce 3.200.000 muertes al año o lo que es lo mismo 6 muertos por minuto.
Consuelo Pérez Rincón, Eufemiano Pérez del Río   +1 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source