Results 191 to 200 of about 429,978 (249)

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Plasma cell-free DNA markers predict occult metastases in patients with resectable pancreatic ductal adenocarcinoma. [PDF]

Clin Transl Med
Till JE, Gal-Rosenberg O, Giliberto SG, Seewald NJ, Ballinger DG, Samberg HE, Yin MR, Wang QL, Cannas S, Kim KN, Tien K, Sawi M, Madineedi V, Furniss CS, Gocheva V, Nowak J, Brais LK, Yuan C, Rosenthal MH, Roses R, DeMatteo R, Lee MK, Vollmer C, Sagreiya H, O'Hara MH, Shemer R, Wolpin B, Dor Y, Carpenter EL.   +28 more
europepmc   +1 more source

Contribuição ao estudo do sistema excretor do pâncreas em eqüinos

, 1973
Maria Helena Corrêa Varella, Irvênia Luíza de Santis Prada, Antônio Fernandes Filho, Vicenti Borelli   +3 more
openalex   +2 more sources

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Response to Commentary on "Reassessing Simultaneous Pancreas Kidney Vs. Kidney Transplant Alone: A Propensity Weighted Analysis of Survival and Morbidity". [PDF]

Transpl Int
Budhiraja P, Lopez R, Arrigain S, Schold JD.   +3 more
europepmc   +1 more source

ESTUDO EPIDEMIOLÓGICO SOBRE NEOPLASIAS DE PÂNCREAS REALIZADO NO PERÍODO DE 2023 – 2024 NO PARANÁ

Gustavo Bruder Sanches Toro, Rafael Ricardo Huppes, Luis Felipe Mattei de Araújo, Amanda Carrasco Huppes, Isabela Pascoli Mira, André Luiz Bravin Ossucci, Ricardo Faltz Fava, Audrei Pavanelli   +7 more
openalex   +2 more sources

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Primary Pancreatic Extra-Nodal Natural Killer T-Cell Lymphoma Presenting as Recurrent Acute Pancreatitis. [PDF]

ACG Case Rep J
Blumrosen C, Mitchell N, Syposs C, Kothari T.   +3 more
europepmc   +1 more source