Results 221 to 230 of about 429,978 (249)

Visceral Metastases of Osteosarcoma in the Hepatopancreatobiliary System. [PDF]

J Clin Med
Hohensteiner A, Kowalscheck L, Döring K, Hobusch GM, Tanios RJ, Strobel O, Windhager R, Funovics PT.   +7 more
europepmc   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Desempenho das diretrizes AGA, Fukuoka e Europeia nos incidentalomas mucinosos do pâncreas submetidos à ultrassonografia endoscópica com punção por agulha fina

Débora Azeredo de Castro Pacheco, Fernando Issamu Tabushi, José Celso Ardengh, Ronaldo Máfia Cuenca, Rafael Dib Possiedi, José Eduardo Ferreira Manso   +5 more
openalex   +2 more sources

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

RNA-binding protein Rbm38 as a multifaceted post-transcriptional regulator in zebrafish pancreatic development. [PDF]

J Mol Cell Biol
Zhang X, Li X, Liu R, Wang L, Wang Y, Zhang A, Yang S, Li H.   +7 more
europepmc   +1 more source

5′tRF‐GlyGCC Promotes Breast Cancer Progression via LDHA‐Mediated Glycolysis and Macrophage Polarization

Advanced Science, EarlyView.
5’tRF‐GlyGCC promotes breast cancer malignancy by binding to LDHA. This interaction, facilitated by FGFR1 and LDHA phosphorylation, enhances glycolysis. Additionally, 5’tRF‐GlyGCC/LDHA signaling recruits and polarizes macrophages into a pro‐tumor M2 state via CCL7, thus remodeling the tumor microenvironment.
Cheng Yi, Yunqing Lu, Xing Chang, Ying Wang, Jiawang Zhou, Guoyou Xie, Lijun Tao, Zhaotong Wang, Yifan Tian, Lihong Wang, Feng Tang, Yijing Zheng, Xinchen Yue, Jinping Lei, Xiansong Wang, Lichen Ge, Zhuojia Chen, Hongsheng Wang   +17 more
wiley   +1 more source

Pancreatic Tuberculosis: Resolution of Pancreatic Pseudocyst and Loculated Ascites Under Tuberculosis Therapy. [PDF]

ACG Case Rep J
Mukanumviye MS, Getaneh FB, Ndagijimana S, Nduwayezu A, Dusabejambo V, Rutaganda E, Nyampinga D, Ingabire Z, Aberra H, Dua KS.   +9 more
europepmc   +1 more source

Adenocarcinoma do pâncreas localmente avançado e metastizado com resposta completa a quimioterapia

, 2007
Paulo Freire, Ana Júlia Andrade Coelho, Ana Sofia Rodrigues, M. R. Silva, Paula Lapa, B. Graça, A Porto   +6 more
openalex   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Exocrine Pancreatic Insufficiency Manifesting Before Insulin Dependence in Adult-Onset Type 1 Diabetes. [PDF]

Clin Case Rep
Pavlou P, Pandit S, Karalliedde J.
europepmc   +1 more source