Results 311 to 320 of about 551,283 (346)

UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis

Advanced Science, EarlyView.
These findings suggest that UCP2 promotes LD formation and release in acinar cells by upregulating ACSL3 expression. This alteration in the local lipid metabolic environment indirectly drives the MMT process. Additionally, UCP2 may regulate the acetylation of Smad3 through Sirt1, enhancing its nuclear activity and activating the TGF‐β/ Smad3 signaling ...
Kunpeng Wang, Lilong Zhang, Beiying Deng, Wanrong Jiang, Tianrui Kuang, Chen Chen, Kailiang Zhao, Qiao Shi, Jun He, Weixing Wang   +9 more
wiley   +1 more source

Importância prognóstica da linfadenectomia no cancro gástrico [PDF]

, 2012
Alexandre José Pinto Sarmento
core  

Phosphate Improves Mitochondrial Function and Reduces Pancreatitis in Hypertriglyceridemia. [PDF]

FASEB J
Mullappilly N, Swain SM, Romac JM, Mikati H, Liddle RA.   +4 more
europepmc   +1 more source

Epigenetic Activation of CCDC183‐AS1 Promotes Osteoclastogenesis and Prostate Cancer Bone Metastasis Through the FUBP1/LIGHT Axis

Advanced Science, EarlyView.
CCDC183‐AS1 overexpression enhanced the ability of PCa cells to spread to the bone by inducing osteoclastogenesis. Mechanistically, CCDC183‐AS1 interacted with FUBP1 and enhanced its stability, which promoted the transcription of TNFSF14 (LIGHT). Copy number gain‐induced KDM5C epigenetically upregulated CCDC183‐AS1 expression by recruiting TET1 to the ...
Chuandong Lang, Xiangyu Mu, Kun Chen, Xinwen Wang, Yuluo Rong, Jia Wang, Zongcheng Yang, Chi Yin, Yuhu Dai, Jun Xiao, Wenzhi Zhang   +10 more
wiley   +1 more source

Adenoma seroso oligoquístico do pâncreas: a propósito de um caso clínico [PDF]

, 2005
Almeida, N, Alves, S, Borges, I, Freitas, D, Gomes, D, Gouveia, H, Gregório, C, Martinho, F, Portela, F, Rui, M, Sérgio, M, Urbano, M   +11 more
core  

Soft graph clustering for single-cell RNA sequencing data. [PDF]

BMC Bioinformatics
Xu P, Wang P, Ning Z, Xiao M, Wu M, Zhou Y.   +5 more
europepmc   +1 more source

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

Advanced Science, EarlyView.
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen, Yijun Lin, Xinyu Zhu, Shixuan Zhuo, Zixuan Li, Cheng Guo, Xiaoyi Ye, Jinzhu Chen, Shuying Wang, Yan Chen   +9 more
wiley   +1 more source

Antineoplastic Effects of Thymoquinone on Pancreatic Atypical Acinar Cell Foci Treated With Azaserine. [PDF]

J Biochem Mol Toxicol
Yildiz H, Hartavi B.
europepmc   +1 more source

Protocol for decellularizing and delipidizing human pancreatic tissue into native hydrogel. [PDF]

STAR Protoc
Chamberlain CS, Tremmel DM, Khan AP, Santos EA, Kapadia D, Leavens C, Gorski KM, Hamadeh R, Feeney AK, Odorico J, Sackett SD.   +10 more
europepmc   +1 more source

Necrose aguda do esófago: caso clínico [PDF]

, 2006
Alves, S, Filipe, C, Garcia, R, Porto, A, Reis, C, Terrível, M, Vaio, T   +6 more
core