Results 41 to 50 of about 551,283 (346)

Perspectives of stem cell therapy in type 2 diabetes mellitus [PDF]

, 2010
A patogênese do diabetes mellitus tipo 2 (DM2) está associada, basicamente, a dois mecanismos, resistência à ação da insulina e disfunção secretória das células pancreáticas.
LEAL, Angela M. O., VOLTARELLI, Júlio César   +1 more
core   +1 more source

Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas

Scientific Reports, 2018
Extracellular matrix (ECM) plays an important developmental role by regulating cell behaviour through structural and biochemical stimulation. Tissue-specific ECM, attained through decellularization, has been proposed in several strategies for tissue and ...
S. Sackett, Daniel M. Tremmel, Fengfei Ma, Austin K. Feeney, Rachel M. Maguire, Matthew E Brown, Ying Zhou, Xia Li, Cori O’Brien, Lingjun Li, W. Burlingham, J. Odorico   +11 more
semanticscholar   +1 more source

Morfologia do pâncreas da paca (Cuniculus paca, Linnaeus, 1766)

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO Este trabalho se baseou na descrição morfológica da paca (Cuniculus paca), espécie selvagem pertencente à ordem dos roedores, típica de regiões tropicais, sendo o seu conhecimento anatômico detalhado muito importante para sua conservação ...
L.C. Fiori, L.M. Leal, T.H.C. Sasahara, F.S. Oliveira, L. Simões, L.L. Martins, S. Garcia Filho, M.R.F. Machado   +7 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Alterações morfológicas pancreáticas induzidas pelo ruído de baixa frequência – Resultados preliminares [PDF]

, 2015
Poster apresentado na XLIX Reunião Científica da Sociedade Portuguesa de Anatomia / II Reunião Científica da Associação Anatómica Portuguesa, 16 Maio 2015, NOVA Medical School /Faculdade de Ciências Médicas - Universidade Nova de ...
Borrecho, Gonçalo, Martins dos Santos, José, Oliveira, Pedro, Pereira, Gonçalo   +3 more
core  

Neoplasia Sólida Pseudopapilar do Pâncreas: Relato de Caso

Gazeta Médica, 2021
A investigação de adenopatia é muito comum na prática clínica, e pode ser complexa face às múltiplas etiologias possíveis. No presente caso, o aparecimento de tumefação cervical num jovem de 25 anos, do sexo masculino, e sua investigação clínica ...
Francisca M. Pereira, Cristina Marques, Joana Esteves, Maria Boncoraglio, Ana Martins, Daniel Martins   +5 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

Diabetes, 2019
Type 1 diabetes risk can reliably be predicted by markers of autoimmunity, but approaches to prevent or modify the underlying disease process are needed.
K. Kaestner, A. Powers, A. Naji, M. Atkinson   +3 more
semanticscholar   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source