Results 31 to 40 of about 93,172 (175)

Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

Molecular Therapy: Nucleic Acids, 2022
Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for antitumor therapy.
Noelia Silva-Pilipich, Aritz Lasarte-Cía, Teresa Lozano, Celia Martín-Otal, Juan José Lasarte, Cristian Smerdou   +5 more
doaj   +1 more source

Humidity‐Corrected Thermodynamic Modeling of Ammonium Chloride Crystallization Temperature Mechanisms and Application

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT As refineries process increasingly inferior crude oils, ammonium salt corrosion has intensified. Accurate prediction of ammonium salt crystallization temperatures and their influencing factors is therefore crucial for safe and stable operations.
Haozhe Jin, Zhibin Yu, Shuangqing Xu, Xiaofei Liu, Wei Chen, Chao Wang, Zhiyuan Han, Xin Liu   +7 more
wiley   +1 more source

Pioglitazone Alleviates Cardiac Fibrosis and Inhibits Endothelial to Mesenchymal Transition Induced by Pressure Overload

Cellular Physiology and Biochemistry, 2017
Background/Aims: Cardiac fibrosis, characterized by an unbalanced production and degradation of extracellular matrix components, is a common pathophysiology of multiple cardiovascular diseases.
Wen-Ying Wei, Ning Zhang, Ling-Li Li, Zhen-Guo Ma, Man Xu, Yu-Pei Yuan, Wei Deng, Qi-Zhu Tang   +7 more
doaj   +1 more source

Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice

BMC Pharmacology and Toxicology, 2021
Background Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a high cumulative
Takaaki Furihata, Satoshi Maekawa, Shingo Takada, Naoya Kakutani, Hideo Nambu, Ryosuke Shirakawa, Takashi Yokota, Shintaro Kinugawa   +7 more
doaj   +1 more source

Discovery by Serendipity: a new context for an old riddle [PDF]

, 2015
In the last years there has been a great improvement in the development of computational methods for combinatorial chemistry applied to drug discovery.
Garcia, Pío
core   +1 more source

«Tan práctico es pensar como cavar la tierra»: filosofía, educación y paisaje en Giner de los Ríos [PDF]

, 2015
Giner de los Ríos transformó el krausismo en una filosofía práctica. De nada sirve la filosofía si no es capaz de suscitar un pensamiento autónomo que inspire a su vez una acción.
Navarro de San Pío, Juan
core   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Deciphering the Role of Post-Translational Modifications and Cellular Location of Hepatitis Delta Virus (HDV) Antigens in HDV-Mediated Liver Damage in Mice

Viruses
Hepatitis D virus (HDV) infection represents the most severe form of chronic viral hepatitis. We have shown that the delivery of HDV replication-competent genomes to the hepatocytes using adeno-associated virus (AAV-HDV) as gene delivery vehicles offers ...
Sheila Maestro, Nahia Gomez-Echarte, Gracian Camps, Carla Usai, Cristina Olagüe, Africa Vales, Rafael Aldabe, Gloria Gonzalez-Aseguinolaza   +7 more
doaj   +1 more source

Pioglitazone stabilizes atherosclerotic plaque by regulating the Th17/Treg balance in AMPK-dependent mechanisms

Cardiovascular Diabetology, 2017
Background Pioglitazone (PIO), a thiazolidinediones drug, is a well-known anti-diabetic medicine, but its anti-atherosclerotic effects remain controversial.
Yuling Tian, Tao Chen, Yan Wu, Lin Yang, Lijun Wang, Xiaojuan Fan, Wei Zhang, Jiahao Feng, Hang Yu, Yanjie Yang, Juan Zhou, Zuyi Yuan, Yue Wu   +12 more
doaj   +1 more source

El lenguaje lúdico como estrategia de fortalecimiento de la comprensión lectora en estudiantes de grado noveno

Grafía, 2021
Este trabajo contribuye a mejorar el nivel de comprensión lectora de los estudiantes de un grado noveno, específicamente en los contenidos de literatura prehispánica.
Argemiro Bustos Gómez, Gladys Zamudio Tobar   +1 more
doaj   +1 more source