Results 171 to 180 of about 58,192 (237)

Methotrexate Toxicity in a Patient With Renal Failure Despite a Normal Methotrexate Concentration: A Case Report and Literature Review

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Methotrexate (MTX) is a folate antagonist widely used as a disease‐modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA), as well as in several malignancies and autoimmune disorders. Although low‐dose MTX (5–20 mg/week) is generally considered safe, it has a narrow therapeutic index, and toxicity can occur even at therapeutic doses,
Fatemeh Afra   +7 more
wiley   +1 more source

An Uncommon Case of Ecthyma Gangrenosum in a Three‐Year‐Old Immunocompetent Child

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
The necrotic lesions on day 10. ABSTRACT Ecthyma gangrenosum (EG) is a rare cutaneous finding of Pseudomonas aeruginosa sepsis, typically in immunocompromised patients. We present EG with septic shock in a previously healthy three‐year‐old child who presented with rapidly progressing necrotic eschars and severe neutropenia.
Shobha Maharjan   +2 more
wiley   +1 more source

Catastrophic Antiphospholipid Syndrome in a Young Female Complicated by Systemic Lupus Erythematosus and Left Atrial Myxoma: A Rare Case Report

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Catastrophic antiphospholipid syndrome (CAPS) is a fulminant and rare variant of antiphospholipid syndrome characterized by rapidly progressive multiorgan thrombosis and a high mortality rate. Its diagnosis is often challenging due to overlapping clinical features with sepsis, thromboembolic disorders, and systemic autoimmune diseases.
Nazmin Ahmed   +4 more
wiley   +1 more source

Immunoglobulin Light Chain Amyloidosis

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
Waxy, purple nodules and plaques distributed across the distal fingers and thenar eminences. ABSTRACT Symmetric, purpuric hand nodules and macroglossia prompted skin biopsy revealing immunoglobulin light chain amyloidosis, leading to the diagnosis of multiple myeloma.
Justin Lyon   +3 more
wiley   +1 more source

Púrpura trombocitopénica idiopática

open access: yes
Se revisaron las historias clínicas de siete pacientes con púrpura trombocitopénica idiopática del servicio de Medicina Interna del Hospital Alberto Sabogal Sologuren del Callao entre enero de 1979 y enero de 1992; todos los casos fueron diagnosticados ...
Instituto Peruano de Seguridad Social   +1 more
core  

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

open access: yesComprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni   +3 more
wiley   +1 more source

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