Results 181 to 190 of about 3,320,793 (217)

Activator protein-1 (AP-1) inhibition prevents endothelial to mesenchymal transition in diabetes-associated atherosclerosis: a translational study. [PDF]

Cardiovasc Diabetol
Khan AW, Aziz M, Sourris KC, Cortes JP, Block TJ, Dai A, Maxwell S, Okabe J, Pyper E, Paneni F, Cooper ME, Jandeleit-Dahm KA.   +11 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Upper mantle low-velocity layer tied to volatile-charged carbonate melts. [PDF]

Sci Adv
Huang Y, Wu G, Liang X, Tao K, Wang Y, Nakamura M, Li Y.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

<i>Pseudomonas aeruginosa</i> Biofilms in Cystic Fibrosis: Interactions, Methods, and Therapeutic Strategies. [PDF]

Biomed Res Int
Núñez-García LÁ, Córdova-Fletes C, Barboza-Cerda MC, Garza-González E.   +3 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Small gifts, big shifts? Testing the role of contact through reciprocal gifting as a prejudice reduction strategy. [PDF]

Br J Soc Psychol
Çoksan S, Tercan M, Bağcı SÇ, Yıldız-Çoksan S.   +3 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Bone Health in Ajman: A Cross-Sectional Study of Bone Mineral Density Among Adults. [PDF]

J Osteoporos
Mohammed NMA, Ali MZ, Jalal K, Suresh Kumar A, Iyer SS, Fathin F, Shamim F, Abdulla RA, Kareem NA, Arora A, Sreedharan J, Muttappallymyalil J.   +11 more
europepmc   +1 more source