Results 51 to 60 of about 3,320,793 (217)

Effects of Periodic Normal Stress Oscillations on Frictional Properties of Simulated Natural Fault Gouges Under In Situ P‐T Conditions

open access: yesGeophysical Research Letters
Induced earthquakes are occasionally associated with stress oscillations resulting from periodic industrial activities. Yet, the effects of stress oscillations on fault friction under realistic subsurface conditions are not fully clear.
Bowen Yu   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

A Note on (𝒞p,α)-Hyponormal Operators

open access: yesJournal of Inequalities and Applications, 2010
We study (𝒞p,α)-normal operators and (𝒞p,α)-hyponormal operators. We show the inclusion relation between these classes under various hypotheses for p and α.
Xiaohuan Wang, Zongsheng Gao
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Oscillatory Property of Solutions for p(t)-Laplacian Equations

open access: yesJournal of Inequalities and Applications, 2007
We consider the oscillatory property of the following p(t)-Laplacian equations −(|u'|p(t)−2u')'=1/tθ(t)g(t,u), t>0. Since there is no Picone-type identity for p(t)- Laplacian equations, it is an unsolved problem that whether the Sturmian ...
Qihu Zhang
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Local Boundedness of Weak Solutions for Nonlinear Parabolic Problem with p(x)-Growth

open access: yesJournal of Inequalities and Applications, 2010
We study the nonlinear parabolic problem with p(x)-growth conditions in the space W1,xLp(x)(Q) and give a local boundedness theorem of weak solutions for the following equation (∂u/∂t)+A(u)=0, where A(u)=−diva(x,t,u,∇u)+a0(x,t,
Yongqiang Fu, Ning Pan
doaj   +1 more source

Remediation of Anomia in lvPPA and svPPA

open access: yesFrontiers in Psychology, 2015
Anomia treatment efficacy has been examined in cases with different subtypes of primary progressive aphasia (PPA), and it has been evaluated in groups of participants with the semantic variant (svPPA), but efficacy has not been examined in groups with ...
Aaron Meyer   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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