Results 61 to 70 of about 3,320,793 (217)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Sign-constancy of Green’s functions for impulsive nonlocal boundary value problems
Boundary Value Problems, 2019 We consider the following second order impulsive differential equation with delays: {(Lx)(t)≡x″(t)+∑j=1paj(t)x′(t−τj(t))+∑j=1pbj(t)x(t−θj(t))=f(t),t∈[0,ω],x(tk)=γkx(tk−0),x′(tk)=δkx′(tk−0),k=1,2,…,r.
A. Domoshnitsky, Iu. Mizgireva
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Nonexistence results for a time-fractional biharmonic diffusion equation
Boundary Value ProblemsWe consider weak solutions of the nonlinear time-fractional biharmonic diffusion equation ∂ t α u + ∂ t β u + u x x x x = h ( t , x ) | u | p $\partial _{t}^{\alpha }u+\partial _{t}^{\beta }u+u_{xxxx}=h(t,x)|u|^{p}$ in ( 0 , ∞ ) × ( 0 , 1 ) $(0,\infty ...
Mohamed Jleli, Bessem Samet
doaj +1 more source
Oscillation in neutral equations with an ?integrally small? coefficient
International Journal of Mathematics and Mathematical Sciences, 1994 Consider the neutral delay differential equationddt[x(t)-P(t)x(t-t)]+Q(t)x(t-d)=0,???t=t0(*)Where P, Q?C([t0,8],R+), t?(0,8) and d?R+. We obtain several sufficient conditions for the oscillation of all solutions of Eq. (*) without the restriction ?t08Q(s)
J. S. Yu, Ming-Po Chen
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source