Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Development and Cross-Validation of the Short Form of the Cultural Competence Scale for Nurses
Asian Nursing Research, 2018 Purpose: To develop and validate the short form of the Korean adaptation of the Cultural Competence Scale for Nurses. Methods: To shorten the 33-item Cultural Competence Scale for Nurses, an expert panel (N = 6) evaluated its content validity.
Duckhee Chae, PhD, RN +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Some applications of uniformly $ p $-convergent sets
, 2020 arXiv admin note: text overlap with arXiv:1912.12454, arXiv:2002 ...
openaire +2 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
A Quadratically Convergent Interior-Point Algorithm for the P*(κ)-Matrix Horizontal Linear Complementarity Problem [PDF]
Journal of Sciences, Islamic Republic of Iran, 2012 In this paper, we present a new path-following interior-point algorithm for -horizontal linear complementarity problems (HLCPs). The algorithm uses only full-Newton steps which has the advantage that no line searchs are needed.
H. Mansouri
doaj
A study on Copson operator and its associated sequence space II
Journal of Inequalities and Applications, 2020 In this paper, we investigate some properties of the domains c ( C n ) $c(C^{n})$ , c 0 ( C n ) $c_{0}(C^{n})$ , and ℓ p ( C n ) $\ell _{p}(C^{n})$ ( 0 < p < 1 ) $(0 ...
Hadi Roopaei
doaj +1 more source
The Relationship between Learning Styles (Convergent and Divergent) and the Effect of Random and Blocked Practices on the Learning of Badminton Serve Skills [PDF]
رشد و یادگیری حرکتی ورزشی, 2015 The present study aimed at determining the relationship between learning styles and the effect of random and blocked practices on learning of badminton serve skills.
Mohammad Taghi Aghdasi, Sima Abdolzadeh
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
An approach to validation of a multidimensional tool
Journal of the College of Community Physicians, 2003 IntroductionShort Form Health Survey-36 (SF-36) is a multidimensional measure of general health which has been used extensively in research on many population groups.
N. S. Gunawardena +2 more
doaj +1 more source