Results 1 to 10 of about 27,549 (207)

Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria. [PDF]

PLoS Pathogens, 2018
Clostridium difficile is a Gram-positive spore-forming anaerobe and a major cause of antibiotic-associated diarrhoea. Disruption of the commensal microbiota, such as through treatment with broad-spectrum antibiotics, is a critical precursor for ...
Ian J Passmore, Marine P M Letertre, Mark D Preston, Irene Bianconi, Mark A Harrison, Fauzy Nasher, Harparkash Kaur, Huynh A Hong, Simon D Baines, Simon M Cutting, Jonathan R Swann, Brendan W Wren, Lisa F Dawson   +12 more
doaj   +7 more sources

Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice [PDF]

Frontiers in Endocrinology, 2023
p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine. p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic toxins that correlate positively with chronic kidney disease and diabetes ...
Pernille Baumann Toft, Amanda Marie Vanslette, Kajetan Trošt, Thomas Moritz, Matthew Paul Gillum, Fredrik Bäckhed, Fredrik Bäckhed, Fredrik Bäckhed, Tulika Arora   +8 more
doaj   +2 more sources

Evidence that p-cresol and IL-6 are adsorbed by the HFR cartridge: towards a new strategy to decrease systemic inflammation in dialyzed patients? [PDF]

PLoS ONE, 2014
Hemodialysis (HD) and hemodiafiltration clear only with a low efficiency the plasma from interleukin-6 and p-cresol, two protein-bound uremic toxins associated with high cardiovascular risk in end stage renal disease.
Eleonora Riccio, Mauro Cataldi, Maristella Minco, Gennaro Argentino, Roberta Russo, Stefania Brancaccio, Andrea Memoli, Lucia Grumetto, Loredana Postiglione, Bruna Guida, Bruno Memoli   +10 more
doaj   +8 more sources

Plasma p-cresol lowering effect of sevelamer in peritoneal dialysis patients: evidence from a Cross-Sectional Observational Study. [PDF]

PLoS ONE, 2013
p-Cresol is a by-product of the metabolism of aromatic aminoacid operated by resident intestinal bacteria. In patients with chronic kidney disease, the accumulation of p-cresol and of its metabolite p-cresyl-sulphate causes endothelial dysfunction and ...
Bruna Guida, Mauro Cataldi, Eleonora Riccio, Lucia Grumetto, Andrea Pota, Silvio Borrelli, Andrea Memoli, Francesco Barbato, Gennaro Argentino, Giuliana Salerno, Bruno Memoli   +10 more
doaj   +3 more sources

The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota [PDF]

Microbiome, 2021
Background Autism spectrum disorders (ASD) are associated with dysregulation of the microbiota-gut-brain axis, changes in microbiota composition as well as in the fecal, serum, and urine levels of microbial metabolites.
Patricia Bermudez-Martin, Jérôme A. J. Becker, Nicolas Caramello, Sebastian P. Fernandez, Renan Costa-Campos, Juliette Canaguier, Susana Barbosa, Laura Martinez-Gili, Antonis Myridakis, Marc-Emmanuel Dumas, Aurélia Bruneau, Claire Cherbuy, Philippe Langella, Jacques Callebert, Jean-Marie Launay, Joëlle Chabry, Jacques Barik, Julie Le Merrer, Nicolas Glaichenhaus, Laetitia Davidovic   +19 more
doaj   +2 more sources

Effects of p-Cresol on Oxidative Stress, Glutathione Depletion, and Necrosis in HepaRG Cells: Comparisons to Other Uremic Toxins and the Role of p-Cresol Glucuronide Formation [PDF]

Pharmaceutics, 2021
The toxicological effects of p-cresol have primarily been attributed to its metabolism products; however, very little human data are available in the key organ (i.e., liver) responsible for the generation of these metabolites.
Sang Zhu, Yan Rong, Tony K. L. Kiang
doaj   +2 more sources

Toward an effective delivery system of a microbial sink of the uremic toxin, p-cresol; an in vitro study with Thauera aminoaromatica S2 [PDF]

Frontiers in Microbiology
Individuals with chronic kidney disease (CKD) suffer from uremia, a condition characterized by the accumulation of uremic toxin in the blood. The aromatic uremic toxin p-cresol, a byproduct of tyrosine fermentation in the gut, binds to plasma albumin and
Prakit Saingam, Rosita Rasyid, Britt Abrahamson, Thomas J. Lie, Bruce J. Godfrey, Jonathan Himmelfarb, Jonathan Himmelfarb, Mari K. H. Winkler   +7 more
doaj   +2 more sources

Identification of novel p-cresol inhibitors that reduce Clostridioides difficile’s ability to compete with species of the gut microbiome [PDF]

Scientific Reports, 2023
Treatment of Clostridioides difficile infection (CDI) is expensive and complex, with a high proportion of patients suffering infection relapse (20–35%), and some having multiple relapses.
Mark A. Harrison, Rebecca J. Farthing, Nyasha Allen, Lucy M. Ahern, Kristian Birchall, Michael Bond, Harparkash Kaur, Brendan W. Wren, Julien R. C. Bergeron, Lisa F. Dawson   +9 more
doaj   +2 more sources

Unraveling p-Cresol: from biosynthesis to biological and biochemical activities [PDF]

Frontiers in Pharmacology
p-Cresol, a ubiquitous low-molecular-weight volatile phenolic compound, permeates the vicinity of human, plant, and animal ecosystems through complex biosynthetic pathways and environmental exposure routes.
Ying Zhang, Ying Zhang, Xinfang Xu, Xiaona Fan, Yuting Wu, Xiufang Zhang, Yingxue Wu, Xiangri Li, Qinwen Zou   +8 more
doaj   +2 more sources

The autism-linked gut microbial metabolite p-cresol inhibits host catecholamine biosynthesizing enzymes to elicit social deficits [PDF]

Communications Biology
Autism spectrum disorder (ASD) is associated with altered gut microbiota and elevated levels of the microbial metabolite p-cresol. We previously demonstrated that -cresol induces social deficits in male mice, alongside reduced excitability of dopamine ...
Geoffroy Mallaret, Juliette Canaguier, Jacques Callebert, Nicolas Caramello, David Fabregat-Safont, Nicolas Glaichenhaus, Oscar J. Pozo, Jean-Marie Launay, Laetitia Davidovic   +8 more
doaj   +2 more sources