Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study. [PDF]
Autism Res, 2022 Chronic constipation is common among children with ASD and is associated with more severe hyperactivity, anxiety, irritability, and repetitive behaviors.
Turriziani L +9 more
europepmc +2 more sources
Tissue Barriers, 2022 The sequential activity of gut microbial and host processes can exert a powerful modulatory influence on dietary components, as exemplified by the metabolism of the amino acids tyrosine and phenylalanine to p-cresol by gut microbes, and then to p-cresol ...
A. Stachulski +4 more
semanticscholar +1 more source
Gut neurotoxin p-cresol induces brain-derived neurotrophic factor secretion and increases the expression of neurofilament subunits in PC-12 cells. [PDF]
AIMS Neurosci, 2022 Increased p-cresol levels reportedly alter brain dopamine metabolism and exacerbate neurological disorders in experimental animals. In contrast to toxic concentrations, low doses of p-cresol may have distinct effects on neuronal metabolism.
Tevzadze G +5 more
europepmc +2 more sources
Journal of Neurochemistry, 2022 Autism spectrum disorder (ASD) is a heterogeneous neurodevelopment disorder resulting from different etiological factors, both genetic and/or environmental.
Sheyla Guzmán Salas +8 more
semanticscholar +1 more source
p-Cresol Sulfate Caused Behavior Disorders and Neurodegeneration in Mice with Unilateral Nephrectomy Involving Oxidative Stress and Neuroinflammation. [PDF]
Int J Mol Sci, 2020 Protein-bound uremic toxins, such as p-cresol sulfate (PCS), can be accumulated with declined renal function and aging and is closely linked with central nervous system (CNS) diseases.
Sun CY +8 more
europepmc +2 more sources
International Journal of Molecular Sciences, 2022 The bacterial metabolite 4-methylphenol (para-cresol or p-cresol) and its derivative p-cresyl sulfate (pCS) are elevated in the urine and feces of children with autism spectrum disorder (ASD). It has been shown that p-cresol administration induces social
Yuanpeng Zheng +6 more
semanticscholar +1 more source
Bioenergetic strategy for the biodegradation of p-cresol by the unicellular green alga Scenedesmus obliquus. [PDF]
PLoS ONE, 2012 Cultures from the unicellular green alga Scenedesmus obliquus biodegrade the toxic p-cresol (4-methylphenol) and use it as alternative carbon/energy source. The biodegradation procedure of p-cresol seems to be a two-step process.
Aikaterini Papazi +2 more
doaj +1 more source
p-Cresol affects reactive oxygen species generation, cell cycle arrest, cytotoxicity and inflammation/atherosclerosis-related modulators production in endothelial cells and mononuclear cells. [PDF]
PLoS ONE, 2014 AIMS: Cresols are present in antiseptics, coal tar, some resins, pesticides, and industrial solvents. Cresol intoxication leads to hepatic injury due to coagulopathy as well as disturbance of hepatic circulation in fatal cases.
Mei-Chi Chang +9 more
doaj +1 more source
International Journal of Medical Sciences, 2021 Chronic kidney disease (CKD) patients obtained high levels of uremic toxins progressively develop several complications including bone fractures. Protein-bound uremic toxins especially p-cresol and indoxyl sulfate are hardly eliminated due to their high ...
Witchayapon Kamprom +5 more
semanticscholar +1 more source
Role of endothelial microvesicles released by p-cresol on endothelial dysfunction. [PDF]
Sci Rep, 2020 Protein bound uremic toxins, such as p-cresol, cannot be effectively removed by conventional dialysis techniques and are accumulated in plasma, thus contributing to progression of both chronic kidney disease (CKD) and cardiovascular disease (CVD ...
Guerrero F +7 more
europepmc +2 more sources