Results 1 to 10 of about 18,472,213 (216)

Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice [PDF]

Frontiers in Endocrinology, 2023
p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine. p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic toxins that correlate positively with chronic kidney disease and diabetes ...
Pernille Baumann Toft, Amanda Marie Vanslette, Kajetan Trošt, Thomas Moritz, Matthew Paul Gillum, Fredrik Bäckhed, Fredrik Bäckhed, Fredrik Bäckhed, Tulika Arora   +8 more
doaj   +4 more sources

The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota [PDF]

Microbiome, 2021
Background Autism spectrum disorders (ASD) are associated with dysregulation of the microbiota-gut-brain axis, changes in microbiota composition as well as in the fecal, serum, and urine levels of microbial metabolites.
Patricia Bermudez-Martin, Jérôme A. J. Becker, Nicolas Caramello, Sebastian P. Fernandez, Renan Costa-Campos, Juliette Canaguier, Susana Barbosa, Laura Martinez-Gili, Antonis Myridakis, Marc-Emmanuel Dumas, Aurélia Bruneau, Claire Cherbuy, Philippe Langella, Jacques Callebert, Jean-Marie Launay, Joëlle Chabry, Jacques Barik, Julie Le Merrer, Nicolas Glaichenhaus, Laetitia Davidovic   +19 more
doaj   +4 more sources

Unraveling p-Cresol: from biosynthesis to biological and biochemical activities [PDF]

Frontiers in Pharmacology
p-Cresol, a ubiquitous low-molecular-weight volatile phenolic compound, permeates the vicinity of human, plant, and animal ecosystems through complex biosynthetic pathways and environmental exposure routes.
Ying Zhang, Ying Zhang, Xinfang Xu, Xiaona Fan, Yuting Wu, Xiufang Zhang, Yingxue Wu, Xiangri Li, Qinwen Zou   +8 more
doaj   +5 more sources

Modelling the role of microbial p-cresol in colorectal genotoxicity. [PDF]

Gut Microbes, 2019
Background: A greater understanding of mechanisms explaining the interactions between diet and the gut microbiota in colorectal cancer is desirable. Genotoxic microbial metabolites present in the colon may be implicated in carcinogenesis and potentially influenced by diet. Aims: We hypothesised that microbial p-cresol is a colonic genotoxin and set out
Al Hinai EA, Kullamethee P, Rowland IR, Swann J, Walton GE, Commane DM.   +5 more
europepmc   +9 more sources

Removal of P-Cresol Sulfate by Hemodialysis [PDF]

Journal of the American Society of Nephrology, 2005
Protein-bound solutes are poorly cleared by dialysis. Among the most extensively studied of these solutes is p-cresol, which has been shown to be toxic in vitro. This study examined the form in which p-cresol circulates and quantified its removal by hemodialysis.
Martinez, Andres W., Recht, Natalie S., Hostetter, Thomas H., Meyer, Timothy W.   +3 more
openaire   +6 more sources

The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains [PDF]

BMC Microbiology, 2011
Background Clostridium difficile is the major cause of antibiotic associated diarrhoea and in recent years its increased prevalence has been linked to the emergence of hypervirulent clones such as the PCR-ribotype 027. Characteristically, C.
McNerney Ruth, Bundy Jake, Barton Richard H, Cartman Stephen T, Donahue Elizabeth H, Dawson Lisa F, Minton Nigel P, Wren Brendan W   +7 more
doaj   +3 more sources

Effects of p-Cresol on Oxidative Stress, Glutathione Depletion, and Necrosis in HepaRG Cells: Comparisons to Other Uremic Toxins and the Role of p-Cresol Glucuronide Formation [PDF]

Pharmaceutics, 2021
The toxicological effects of p-cresol have primarily been attributed to its metabolism products; however, very little human data are available in the key organ (i.e., liver) responsible for the generation of these metabolites.
Sang Zhu, Yan Rong, Tony K. L. Kiang
doaj   +2 more sources

Toward an effective delivery system of a microbial sink of the uremic toxin, p-cresol; an in vitro study with Thauera aminoaromatica S2 [PDF]

Frontiers in Microbiology
Individuals with chronic kidney disease (CKD) suffer from uremia, a condition characterized by the accumulation of uremic toxin in the blood. The aromatic uremic toxin p-cresol, a byproduct of tyrosine fermentation in the gut, binds to plasma albumin and
Prakit Saingam, Rosita Rasyid, Britt Abrahamson, Thomas J. Lie, Bruce J. Godfrey, Jonathan Himmelfarb, Jonathan Himmelfarb, Mari K. H. Winkler   +7 more
doaj   +2 more sources

Identification of novel p-cresol inhibitors that reduce Clostridioides difficile’s ability to compete with species of the gut microbiome [PDF]

Scientific Reports, 2023
Treatment of Clostridioides difficile infection (CDI) is expensive and complex, with a high proportion of patients suffering infection relapse (20–35%), and some having multiple relapses.
Mark A. Harrison, Rebecca J. Farthing, Nyasha Allen, Lucy M. Ahern, Kristian Birchall, Michael Bond, Harparkash Kaur, Brendan W. Wren, Julien R. C. Bergeron, Lisa F. Dawson   +9 more
doaj   +2 more sources

The autism-linked gut microbial metabolite p-cresol inhibits host catecholamine biosynthesizing enzymes to elicit social deficits [PDF]

Communications Biology
Autism spectrum disorder (ASD) is associated with altered gut microbiota and elevated levels of the microbial metabolite p-cresol. We previously demonstrated that -cresol induces social deficits in male mice, alongside reduced excitability of dopamine ...
Geoffroy Mallaret, Juliette Canaguier, Jacques Callebert, Nicolas Caramello, David Fabregat-Safont, Nicolas Glaichenhaus, Oscar J. Pozo, Jean-Marie Launay, Laetitia Davidovic   +8 more
doaj   +2 more sources