Results 1 to 10 of about 25,428,926 (209)

The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota [PDF]

Microbiome, 2021
Background Autism spectrum disorders (ASD) are associated with dysregulation of the microbiota-gut-brain axis, changes in microbiota composition as well as in the fecal, serum, and urine levels of microbial metabolites.
Patricia Bermudez-Martin, Jérôme A. J. Becker, Nicolas Caramello, Sebastian P. Fernandez, Renan Costa-Campos, Juliette Canaguier, Susana Barbosa, Laura Martinez-Gili, Antonis Myridakis, Marc-Emmanuel Dumas, Aurélia Bruneau, Claire Cherbuy, Philippe Langella, Jacques Callebert, Jean-Marie Launay, Joëlle Chabry, Jacques Barik, Julie Le Merrer, Nicolas Glaichenhaus, Laetitia Davidovic   +19 more
doaj   +3 more sources

Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice [PDF]

Frontiers in Endocrinology, 2023
p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine. p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic toxins that correlate positively with chronic kidney disease and diabetes ...
Pernille Baumann Toft, Amanda Marie Vanslette, Kajetan Trošt, Thomas Moritz, Matthew Paul Gillum, Fredrik Bäckhed, Fredrik Bäckhed, Fredrik Bäckhed, Tulika Arora   +8 more
doaj   +2 more sources

Effects of p-Cresol on Oxidative Stress, Glutathione Depletion, and Necrosis in HepaRG Cells: Comparisons to Other Uremic Toxins and the Role of p-Cresol Glucuronide Formation [PDF]

Pharmaceutics, 2021
The toxicological effects of p-cresol have primarily been attributed to its metabolism products; however, very little human data are available in the key organ (i.e., liver) responsible for the generation of these metabolites.
Sang Zhu, Yan Rong, Tony K. L. Kiang
doaj   +2 more sources

Toward an effective delivery system of a microbial sink of the uremic toxin, p-cresol; an in vitro study with Thauera aminoaromatica S2 [PDF]

Frontiers in Microbiology
Individuals with chronic kidney disease (CKD) suffer from uremia, a condition characterized by the accumulation of uremic toxin in the blood. The aromatic uremic toxin p-cresol, a byproduct of tyrosine fermentation in the gut, binds to plasma albumin and
Prakit Saingam, Rosita Rasyid, Britt Abrahamson, Thomas J. Lie, Bruce J. Godfrey, Jonathan Himmelfarb, Jonathan Himmelfarb, Mari K. H. Winkler   +7 more
doaj   +2 more sources

Systemic elevation of gut derived p-cresol during one year in space: implications for brain, heart, bone, liver and microbiome in astronauts [PDF]

Frontiers in Physiology
IntroductionWe observed the elevation of p-cresol in the untargeted metabolome of the multiomics portion of the NASA Twins Study of One Year in Space.
Michael A. Schmidt, Michael A. Schmidt, Michael A. Schmidt, Caleb M. Schmidt, Caleb M. Schmidt, Julian C. Schmidt, Cem Meydan, Cem Meydan, Cem Meydan, Evan E. Afshin, Evan E. Afshin, Eliah G. Overbey, Eliah G. Overbey, Eliah G. Overbey, JangKeun Kim, JangKeun Kim, Ruth Subhash Singh, Afshin Beheshti, Afshin Beheshti, Afshin Beheshti, Afshin Beheshti, Afshin Beheshti, Christopher E. Mason, Christopher E. Mason, Christopher E. Mason, Christopher E. Mason, Christopher E. Mason, Christopher E. Mason   +27 more
doaj   +2 more sources

Identification of novel p-cresol inhibitors that reduce Clostridioides difficile’s ability to compete with species of the gut microbiome [PDF]

Scientific Reports, 2023
Treatment of Clostridioides difficile infection (CDI) is expensive and complex, with a high proportion of patients suffering infection relapse (20–35%), and some having multiple relapses.
Mark A. Harrison, Rebecca J. Farthing, Nyasha Allen, Lucy M. Ahern, Kristian Birchall, Michael Bond, Harparkash Kaur, Brendan W. Wren, Julien R. C. Bergeron, Lisa F. Dawson   +9 more
doaj   +2 more sources

The autism-linked gut microbial metabolite p-cresol inhibits host catecholamine biosynthesizing enzymes to elicit social deficits [PDF]

Communications Biology
Autism spectrum disorder (ASD) is associated with altered gut microbiota and elevated levels of the microbial metabolite p-cresol. We previously demonstrated that -cresol induces social deficits in male mice, alongside reduced excitability of dopamine ...
Geoffroy Mallaret, Juliette Canaguier, Jacques Callebert, Nicolas Caramello, David Fabregat-Safont, Nicolas Glaichenhaus, Oscar J. Pozo, Jean-Marie Launay, Laetitia Davidovic   +8 more
doaj   +2 more sources

Unraveling p-Cresol: from biosynthesis to biological and biochemical activities [PDF]

Frontiers in Pharmacology
p-Cresol, a ubiquitous low-molecular-weight volatile phenolic compound, permeates the vicinity of human, plant, and animal ecosystems through complex biosynthetic pathways and environmental exposure routes.
Ying Zhang, Ying Zhang, Xinfang Xu, Xiaona Fan, Yuting Wu, Xiufang Zhang, Yingxue Wu, Xiangri Li, Qinwen Zou   +8 more
doaj   +2 more sources

Perinatal exposure to the autism-linked metabolite p-Cresol has limited impact on early development in mice but lasting effects on adult social behavior [PDF]

Scientific Reports
Environmental exposures during pregnancy are increasingly recognized as significant risk factors for the offspring health. Perinatal exposure to environmental toxins, including p-Cresol, may disrupt essential physiological processes during critical ...
Juliette Canaguier, Geoffroy Mallaret, Cristina Paraschivescu, Susana Barbosa, Julie Le Merrer, Jérôme Becker, Nicolas Glaichenhaus, Laetitia Davidovic   +7 more
doaj   +2 more sources

Microbial and metabolic basis of p-cresol formation in fermented bamboo shoots (suansun): The central role of Levilactobacillus zymae KUST4216 [PDF]

Food Chemistry: X
p-Cresol plays a pivotal role in shaping the flavor quality of suansun. This study examined the effect of inoculating Levilactobacillus zymae KUST4216, a high p-cresol-producing strain, on the fermentation of suansun.
Zi Ye, Xinyu Wang, Tao Wang, Chuanqi Chu, Zhijia Liu, Leilei Yu, Ming Du, Junjie Yi   +7 more
doaj   +2 more sources