Toxins, 2021 Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting in uremia. Uremic toxins are classified into three categories: free
Bradley L Urquhart, Nicholas C Tonial
exaly +4 more sources
How Do Uremic Toxins Affect the Endothelium?
Toxins, 2020 Uremic toxins can induce endothelial dysfunction in patients with chronic kidney disease (CKD). Indeed, the structure of the endothelial monolayer is damaged in CKD, and studies have shown that the uremic toxins contribute to the loss of cell–cell ...
Andressa Flores Santos +2 more
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Derivation and Elimination of Uremic Toxins From Kidney-Gut Axis [PDF]
Frontiers in Physiology, 2023 Uremic toxins are chemicals, organic or inorganic, that accumulate in the body fluids of individuals with acute or chronic kidney disease and impaired renal function.
Zhiyong Guo
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Gut-Derived Protein-Bound Uremic Toxins
Toxins, 2020 Chronic kidney disease (CKD) afflicts more than 500 million people worldwide and is one of the fastest growing global causes of mortality. When glomerular filtration rate begins to fall, uremic toxins accumulate in the serum and significantly increase ...
Amanda L Graboski, Matthew R. Redinbo
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The Interplay Between Uremic Toxins and Albumin, Membrane Transporters and Drug Interaction
Toxins, 2022 Uremic toxins are a heterogeneous group of molecules that accumulate in the body due to the progression of chronic kidney disease (CKD). These toxins are associated with kidney dysfunction and the development of comorbidities in patients with CKD, being ...
Sophie Liabeuf +2 more
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Uremic Toxins and Mortality in Patients With Acute Kidney Injury Prior to and During Continuous Kidney Replacement Therapy [PDF]
Kidney MedicineRationale & Objective: Uremia is an indication for continuous kidney replacement therapy (CKRT) in patients with acute kidney injury (AKI). Existing studies of uremic toxins in AKI have several limitations, including modest cohort sizes and small ...
Isadore M. Budnick +20 more
doaj +2 more sources
Targeting Uremic Toxins in Chronic Kidney Disease: Current Challenges and Emerging Therapeutic Strategies [PDF]
ToxinsChronic kidney disease (CKD) represents a significant public health problem. Patients with CKD have high morbidity and mortality, mainly due to cardiovascular diseases.
Regiane Stafim da Cunha +4 more
doaj +2 more sources
Uremic Toxins and the Lung Alveolar Capillary Barrier: A Narrative Review [PDF]
ToxinsIntroduction: Uremic toxins have been shown to cause adverse pulmonary effects by inducing endothelial and epithelial dysfunction, disrupting the alveolar-capillary barrier, and increasing inflammation and oxidative stress.
Saleh Kaysi +5 more
doaj +2 more sources
Vascular inflammation in chronic kidney disease: the role of uremic toxins in macrophage activation [PDF]
Frontiers in Cardiovascular MedicineChronic kidney disease (CKD) is a progressive condition characterized by the gradual loss of kidney function, leading to the accumulation of uremic toxins in the bloodstream.
Prabhash Kumar Jha +10 more
doaj +2 more sources
Development of a convenient and rapid screening zebrafish model to investigate lethal effects and immunocompromised states of uremic toxins [PDF]
Renal FailureBackground Uremia is characterized by high mortality and immune dysfunction owing to the accumulation of uremic toxins. Traditional rodent models are complex and time consuming.
Pema Jo +7 more
doaj +2 more sources