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Toxins, 2021 Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting in uremia. Uremic toxins are classified into three categories: free
Brad Urquhart +2 more
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Derivation and elimination of uremic toxins from kidney-gut axis
Frontiers in Physiology, 2023 Uremic toxins are chemicals, organic or inorganic, that accumulate in the body fluids of individuals with acute or chronic kidney disease and impaired renal function.
Wang Hai-Yan
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The Interplay between Uremic Toxins and Albumin, Membrane Transporters and Drug Interaction
Toxins, 2022 Uremic toxins are a heterogeneous group of molecules that accumulate in the body due to the progression of chronic kidney disease (CKD). These toxins are associated with kidney dysfunction and the development of comorbidities in patients with CKD, being ...
Sophie Liabeuf +2 more
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Uremic Toxins and the Lung Alveolar Capillary Barrier: A Narrative Review [PDF]
ToxinsIntroduction: Uremic toxins have been shown to cause adverse pulmonary effects by inducing endothelial and epithelial dysfunction, disrupting the alveolar-capillary barrier, and increasing inflammation and oxidative stress.
Saleh Kaysi +5 more
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Food-Derived Uremic Toxins in Chronic Kidney Disease
Toxins, 2023 Patients with chronic kidney disease (CKD) have a higher cardiovascular risk compared to the average population, and this is partially due to the plasma accumulation of solutes known as uremic toxins.
Ricard Farré +2 more
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How do Uremic Toxins Affect the Endothelium?
Toxins, 2020 Uremic toxins can induce endothelial dysfunction in patients with chronic kidney disease (CKD). Indeed, the structure of the endothelial monolayer is damaged in CKD, and studies have shown that the uremic toxins contribute to the loss of cell–cell ...
Andressa Santos +2 more
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Uremic Toxins in Organ Crosstalk [PDF]
Frontiers in Medicine, 2021 Many putative uremic toxins—like indoxyl sulfate, p-cresol sulfate, kynurenic acid, uric acid, and CMPF—are organic anions. Both inter-organ and inter-organismal communication are involved.
Jerome Lowenstein, Sanjay K. Nigam
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Uremic Toxins: An Alarming Danger Concerning the Cardiovascular System
Frontiers in Physiology, 2021 The kidneys and heart share functions with the common goal of maintaining homeostasis. When kidney injury occurs, many compounds, the so-called “uremic retention solutes” or “uremic toxins,” accumulate in the circulation targeting other tissues.
Carolina Victoria Cruz Junho +2 more
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Toxins, 2014 Patients with chronic kidney disease (CKD) have a higher risk of cardiovascular diseases and suffer from accelerated atherosclerosis. CKD patients are permanently exposed to uremic toxins, making them good candidates as pathogenic agents.
Laetitia Dou +2 more
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Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders [PDF]
Frontiers in EndocrinologyCardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, and cardiovascular diseases, leading to multi-organ ...
Shihan Zhang +6 more
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