Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients. [PDF]
PLoS ONE, 2017 Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points.
Sunny Eloot +7 more
doaj +10 more sources
Uremic Toxins and the Lung Alveolar Capillary Barrier: A Narrative Review [PDF]
ToxinsIntroduction: Uremic toxins have been shown to cause adverse pulmonary effects by inducing endothelial and epithelial dysfunction, disrupting the alveolar-capillary barrier, and increasing inflammation and oxidative stress.
Saleh Kaysi +5 more
doaj +2 more sources
Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders [PDF]
Frontiers in EndocrinologyCardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, and cardiovascular diseases, leading to multi-organ ...
Shihan Zhang +6 more
doaj +2 more sources
Vascular inflammation in chronic kidney disease: the role of uremic toxins in macrophage activation [PDF]
Frontiers in Cardiovascular MedicineChronic kidney disease (CKD) is a progressive condition characterized by the gradual loss of kidney function, leading to the accumulation of uremic toxins in the bloodstream.
Prabhash Kumar Jha +10 more
doaj +2 more sources
Association between Dental Scores and Saliva Uremic Toxins [PDF]
Toxins, 2023 Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins ...
Claire Rigothier +8 more
doaj +2 more sources
Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor [PDF]
Cellular & Molecular Biology LettersAryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed that AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the ...
Hongyan Xie +3 more
doaj +2 more sources
Development of a convenient and rapid screening zebrafish model to investigate lethal effects and immunocompromised states of uremic toxins [PDF]
Renal FailureBackground Uremia is characterized by high mortality and immune dysfunction owing to the accumulation of uremic toxins. Traditional rodent models are complex and time consuming.
Pema Jo +7 more
doaj +2 more sources
Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach [PDF]
European Journal of Medical ResearchBackground Chronic kidney disease presents global health challenges, with hemodialysis as a common treatment. However, non-dialyzable uremic toxins demand further investigation for new therapeutic approaches.
Roya Asadi +2 more
doaj +2 more sources
Response to Tsikas et al. comments on Boelaert et al. Determination of asymmetric and symmetric dimethylarginine in serum from patients with chronic kidney disease: UPLC-MS/MS versus ELISA. Toxins 2016, 8, 149 [PDF]
, 2016 n/
Boelaert, Jente +5 more
core +13 more sources
Derivation and elimination of uremic toxins from kidney-gut axis
Frontiers in Physiology, 2023 Uremic toxins are chemicals, organic or inorganic, that accumulate in the body fluids of individuals with acute or chronic kidney disease and impaired renal function.
Ying Xu +7 more
doaj +1 more source