Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies [PDF]
Toxins, 2016 Indoxyl sulfate is an extensively studied uremic solute. It is a small molecule that is more than 90% bound to plasma proteins. Indoxyl sulfate is derived from the breakdown of tryptophan by colon microbes.
Sheldon C. Leong, Tammy L. Sirich
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Indoxyl Sulfate, a Uremic Endotheliotoxin [PDF]
Toxins, 2020 Chronic kidney disease (CKD) is associated with a high prevalence of cardiovascular diseases. During CKD, the uremic toxin indoxyl sulfate (IS)—derived from tryptophan metabolism—accumulates.
Guillaume Lano +2 more
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-Cresyl sulfate and indoxyl sulfate in pediatric patients on chronic dialysis [PDF]
Korean Journal of Pediatrics, 2013 PurposeIndoxyl sulfate and p-cresyl sulfate are important protein-bound uremic retention solutes whose levels can be partially reduced by renal replacement therapy. These solutes originate from intestinal bacterial protein fermentation and are associated
Hye Sun Hyun +2 more
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Indoxyl Sulfate and Incident Peripheral Artery Disease in Hemodialysis Patients [PDF]
Toxins, 2020 Peripheral artery disease (PAD) is highly prevalent among patients with chronic kidney disease (CKD) and portends a very poor prognosis. Indoxyl sulfate has been shown to induce atherothrombosis and impaired neovascularization in uremic mice.
Ting-Yun Lin +3 more
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Correlation Between Indoxyl Sulfate in Chronic Kidney Disease and Olfactory Dysfunction [PDF]
Iranian Journal of OtorhinolaryngologyIntroduction: Olfactory dysfunction is prevalent among individuals with chronic kidney disease (CKD), with prevalence escalating alongside disease severity.
Irnanda Nasution +6 more
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Indoxyl Sulfate in the Gut–Kidney Axis: Pathophysiology and Clinical Significance in CKD-Associated Colorectal Cancer [PDF]
ToxinsChronic Kidney Disease (CKD) and Colorectal Cancer (CRC) share a profound epidemiological link, supported by Mendelian randomization studies suggesting causality.
Hidehisa Shimizu, Toshimitsu Niwa
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Correlation of Indoxyl Sulfate to Hearing Impairment in Chronic Kidney Disease Patients [PDF]
Iranian Journal of OtorhinolaryngologyIntroduction: Chronic Kidney Disease (CKD) is considered a public health issue because its frequency is increasing in adults. When a person experiences renal failure, one of the most researched solutes that builds up in plasma is indoxyl sulfate.
Fadillah Sanjani +7 more
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Indoxyl sulfate impairs valsartan-induced neovascularization
Redox Biology, 2020 Studies revealed that the use of renin-angiotensin-aldosterone system antagonism is not associated with a statistically significant reduction in the risk of cardiovascular events in patients with chronic kidney disease (CKD) compared with that in the ...
Ko-Lin Kuo +5 more
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Retention of indoxyl sulfate in different genotypes of ABCC2 may explain variation in tacrolimus pharmacokinetics [PDF]
PeerJBackground Microbiota-derived toxins indoxyl sulfate and hippuric acid were previously reported to be associated with altered pharmacokinetics of the immunosuppressant tacrolimus in liver transplant recipients, and ABC transporter proteins are likely to ...
Jing Wang +5 more
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Myostatin Exacerbates Endothelial Dysfunction Induced by Uremic Toxin Indoxyl Sulfate and Is Associated with Hemodialysis Arteriovenous Access Complications [PDF]
ToxinsHemodialysis patients exhibit endothelial dysfunction, contributing to elevated cardiovascular risk and complications of the arteriovenous access. These patients have elevated serum levels of myostatin, a member of the transforming growth factor-β (TGFβ)
Justine Solignac +10 more
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