Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies
Toxins, 2016 Indoxyl sulfate is an extensively studied uremic solute. It is a small molecule that is more than 90% bound to plasma proteins. Indoxyl sulfate is derived from the breakdown of tryptophan by colon microbes.
Sheldon C. Leong, Tammy L. Sirich
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Indoxyl Sulfate in the Gut–Kidney Axis: Pathophysiology and Clinical Significance in CKD-Associated Colorectal Cancer [PDF]
ToxinsChronic Kidney Disease (CKD) and Colorectal Cancer (CRC) share a profound epidemiological link, supported by Mendelian randomization studies suggesting causality.
Hidehisa Shimizu, Toshimitsu Niwa
doaj +2 more sources
Correlation Between Indoxyl Sulfate in Chronic Kidney Disease and Olfactory Dysfunction [PDF]
Iranian Journal of OtorhinolaryngologyIntroduction: Olfactory dysfunction is prevalent among individuals with chronic kidney disease (CKD), with prevalence escalating alongside disease severity.
Irnanda Nasution +6 more
doaj +2 more sources
Correlation of Indoxyl Sulfate to Hearing Impairment in Chronic Kidney Disease Patients [PDF]
Iranian Journal of OtorhinolaryngologyIntroduction: Chronic Kidney Disease (CKD) is considered a public health issue because its frequency is increasing in adults. When a person experiences renal failure, one of the most researched solutes that builds up in plasma is indoxyl sulfate.
Fadillah Sanjani +7 more
doaj +2 more sources
Myostatin Exacerbates Endothelial Dysfunction Induced by Uremic Toxin Indoxyl Sulfate and Is Associated with Hemodialysis Arteriovenous Access Complications [PDF]
ToxinsHemodialysis patients exhibit endothelial dysfunction, contributing to elevated cardiovascular risk and complications of the arteriovenous access. These patients have elevated serum levels of myostatin, a member of the transforming growth factor-β (TGFβ)
Justine Solignac +10 more
doaj +2 more sources
Retention of indoxyl sulfate in different genotypes of ABCC2 may explain variation in tacrolimus pharmacokinetics [PDF]
PeerJBackground Microbiota-derived toxins indoxyl sulfate and hippuric acid were previously reported to be associated with altered pharmacokinetics of the immunosuppressant tacrolimus in liver transplant recipients, and ABC transporter proteins are likely to ...
Jing Wang +5 more
doaj +3 more sources
Metabolomics Profiling Reveals Critical Roles of Indoxyl Sulfate in the Regulation of Innate Monocytes in COVID-19 [PDF]
CellsThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is intricately related to the reprogramming of host metabolism. However, existing studies have mainly focused on peripheral blood samples and barely identified specific ...
Liqing He +12 more
doaj +2 more sources
Indoxyl Sulfate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients
Global Medical & Health Communication, 2023 Executive function is a crucial cognitive domain that can be adversely affected by various toxic substances, including the uremic toxin indoxyl sulfate.
Yuliarni Syafrita +3 more
doaj +1 more source
Indoxyl Sulfate and Autism Spectrum Disorder: A Literature Review [PDF]
International Journal of Molecular SciencesJames Adams, Adams James B
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Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand. [PDF]
PLoS ONE, 2014 Indoxyl sulfate is a uremic toxin and a ligand of the aryl-hydrocarbon receptor (AhR), a transcriptional regulator. Elevated serum indoxyl sulfate levels may contribute to progressive kidney disease and associated vascular disease.
Osamu Ichii +7 more
doaj +1 more source