Results 11 to 20 of about 6,816 (174)
-Cresyl sulfate and indoxyl sulfate in pediatric patients on chronic dialysis [PDF]
Korean Journal of Pediatrics, 2013 PurposeIndoxyl sulfate and p-cresyl sulfate are important protein-bound uremic retention solutes whose levels can be partially reduced by renal replacement therapy. These solutes originate from intestinal bacterial protein fermentation and are associated
Hye Sun Hyun +2 more
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Indoxyl Sulfate, a Uremic Endotheliotoxin [PDF]
Toxins, 2020 Chronic kidney disease (CKD) is associated with a high prevalence of cardiovascular diseases. During CKD, the uremic toxin indoxyl sulfate (IS)—derived from tryptophan metabolism—accumulates.
Guillaume Lano +2 more
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Indoxyl sulfate impairs valsartan-induced neovascularization
Redox Biology, 2020 Studies revealed that the use of renin-angiotensin-aldosterone system antagonism is not associated with a statistically significant reduction in the risk of cardiovascular events in patients with chronic kidney disease (CKD) compared with that in the ...
Ko-Lin Kuo +5 more
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Clinical Journal of the American Society of Nephrology, 2011 The action of colon microbes on undigested proteins gives rise to a variety of indoles and phenols that are conjugated by the liver before excretion by the kidney. Among the most abundant of the excreted compounds is indoxyl sulfate (IS), which was shown more than 100 years ago to accumulate in ...
Tammy Sirich, Timothy W. Meyer
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Toxic Effects of Indoxyl Sulfate on Osteoclastogenesis and Osteoblastogenesis [PDF]
International Journal of Molecular Sciences, 2021 Uremic toxins, such as indoxyl sulfate (IS) and kynurenine, accumulate in the blood in the event of kidney failure and contribute to further bone damage. To maintain the homeostasis of the skeletal system, bone remodeling is a persistent process of bone formation and bone resorption that depends on a dynamic balance of osteoblasts and osteoclasts.
Jia-Fwu Shyu +8 more
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Indoxyl sulfate in uremia: an old idea with updated concepts [PDF]
Journal of Clinical Investigation, 2022 Patients with end-stage kidney disease (ESKD) have increased vascular disease. While protein-bound molecules that escape hemodialysis may contribute to uremic toxicity, specific contributing toxins remain ambiguous. In this issue of the JCI, Arinze et al.
Anders H. Berg +2 more
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Renal Replacement Therapy, 2022 Background Chronic kidney disease (CKD) is frequently associated with renal anemia. Erythropoiesis-stimulating agent-hyporesponsive anemia is often caused by iron deficiency in patients with CKD. We hypothesized that high accumulation of indoxyl sulfate,
Takuya Yoshida +16 more
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Hepatic microsomal metabolism of indole to indoxyl, a precursor of indoxyl sulfate [PDF]
European Journal of Drug Metabolism and Pharmacokinetics, 2001 The aim of our study was to determine which microsomal cytochrome P450 isozyme(s) were responsible for the microsomal oxidation of indole to indoxyl, an important intermediate in the information of the uremic toxin indoxyl sulfate. Indole was incubated together with an NADPH-generating system and rat liver microsomes.
Banoglu, Erden +2 more
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Indoxyl Sulfate and Incident Peripheral Artery Disease in Hemodialysis Patients
Toxins, 2020 Peripheral artery disease (PAD) is highly prevalent among patients with chronic kidney disease (CKD) and portends a very poor prognosis. Indoxyl sulfate has been shown to induce atherothrombosis and impaired neovascularization in uremic mice.
Ting-Yun Lin +3 more
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The Evolving View of Uremic Toxicity
Toxins, 2022 Indoxyl sulfate, closely related to indigo, a dye valued for it binding to cloth, has been recognized as a protein-bound solute bound to albumin, present in increased concentration in the serum of patients with impaired glomerular filtration (13).
Bjorn Meijers, Jerome Lowenstein
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