Results 11 to 20 of about 11,454 (213)
Indoxyl Sulfate and Autism Spectrum Disorder: A Literature Review. [PDF]
Int J Mol SciIndoxyl sulfate—a bacterially derived metabolite—has been identified as a toxin that is elevated in children with autism spectrum disorder (ASD). As a neurotoxin, uremic toxin, nephrotoxin, cardiotoxin, osteotoxin, and myotoxin, indoxyl sulfate has been associated with several other conditions, including chronic kidney disease, acute kidney injury ...
Hill ZR, Flynn CK, Adams JB.
europepmc +3 more sources
Metabolomics Profiling Reveals Critical Roles of Indoxyl Sulfate in the Regulation of Innate Monocytes in COVID-19 [PDF]
CellsThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is intricately related to the reprogramming of host metabolism. However, existing studies have mainly focused on peripheral blood samples and barely identified specific ...
Liqing He +12 more
doaj +2 more sources
Indoxyl Sulfate Suppresses Hpdlc Osteogenesis Through Ferroptosis
International Dental JournalAim or purpose: Human periodontal ligament stem cells (hPDLCs) play pivotal roles in periodontal tissue repair and bone regeneration. This study investigated the inhibitory effects and underlying mechanisms of indoxyl sulfate (IS), a uremic toxin, on the
Huiwen Chen, Zhongchen Song
doaj +2 more sources
, 2017 If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Glorieux, Griet +3 more
core +14 more sources
Indoxyl Sulfate Levels and Its Relation with Executive Function in Routine Hemodialysis Patients
Global Medical & Health Communication, 2023 Executive function is a crucial cognitive domain that can be adversely affected by various toxic substances, including the uremic toxin indoxyl sulfate.
Yuliarni Syafrita +3 more
doaj +1 more source
Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients [PDF]
, 2017 Background and aim : Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points.
Delrue, Willem +7 more
core +9 more sources
Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand. [PDF]
PLoS ONE, 2014 Indoxyl sulfate is a uremic toxin and a ligand of the aryl-hydrocarbon receptor (AhR), a transcriptional regulator. Elevated serum indoxyl sulfate levels may contribute to progressive kidney disease and associated vascular disease.
Osamu Ichii +7 more
doaj +1 more source
Clinical Journal of the American Society of Nephrology, 2011 The action of colon microbes on undigested proteins gives rise to a variety of indoles and phenols that are conjugated by the liver before excretion by the kidney. Among the most abundant of the excreted compounds is indoxyl sulfate (IS), which was shown more than 100 years ago to accumulate in ...
Tammy Sirich, Timothy W. Meyer
openaire +1 more source
Toxic Effects of Indoxyl Sulfate on Osteoclastogenesis and Osteoblastogenesis [PDF]
International Journal of Molecular Sciences, 2021 Uremic toxins, such as indoxyl sulfate (IS) and kynurenine, accumulate in the blood in the event of kidney failure and contribute to further bone damage. To maintain the homeostasis of the skeletal system, bone remodeling is a persistent process of bone formation and bone resorption that depends on a dynamic balance of osteoblasts and osteoclasts.
Jia-Fwu Shyu +8 more
openaire +2 more sources
Renal Replacement Therapy, 2022 Background Chronic kidney disease (CKD) is frequently associated with renal anemia. Erythropoiesis-stimulating agent-hyporesponsive anemia is often caused by iron deficiency in patients with CKD. We hypothesized that high accumulation of indoxyl sulfate,
Takuya Yoshida +16 more
doaj +1 more source