Results 21 to 30 of about 11,454 (213)

Sulfation of indoxyl by human and rat aryl (phenol) sulfotransferases to form indoxyl sulfate [PDF]

European Journal of Drug Metabolism and Pharmacokinetics, 2002
The aim of this study was to identify sulfotransferase (SULT) isoform(s) responsible for the formation of indoxyl sulfate from indoxyl (3-hydroxyindole). Indoxyl was incubated together with the co-substrate 3'-phosphoadenosine 5'-phosphosulfate (PAPS) and either human or rat liver cytosol or recombinant sulfotransferase enzymes.
Banoglu, E., King, S.
openaire   +4 more sources

p-Cresyl Sulfate and Indoxyl Sulfate in Hemodialysis Patients [PDF]

Clinical Journal of the American Society of Nephrology, 2009
Indoxyl sulfate and p-cresyl sulfate are important representatives of the protein-bound uremic retention solutes. Serum levels of p-cresyl sulfate and indoxyl sulfate are linked to cardiovascular outcomes and chronic kidney disease progression, respectively.
Björn K I, Meijers, Henriette, De Loor, Bert, Bammens, Kristin, Verbeke, Yves, Vanrenterghem, Pieter, Evenepoel   +5 more
openaire   +2 more sources

The Evolving View of Uremic Toxicity

Toxins, 2022
Indoxyl sulfate, closely related to indigo, a dye valued for it binding to cloth, has been recognized as a protein-bound solute bound to albumin, present in increased concentration in the serum of patients with impaired glomerular filtration (13).
Bjorn Meijers, Jerome Lowenstein
doaj   +1 more source

Indoxyl-Sulfate-Induced Redox Imbalance in Chronic Kidney Disease [PDF]

Antioxidants, 2021
The accumulation of the uremic toxin indoxyl sulfate (IS) induces target organ damage in chronic kidney disease (CKD) patients, and causes complications including cardiovascular diseases, renal osteodystrophy, muscle wasting, and anemia. IS stimulates reactive oxygen species (ROS) production in CKD, which impairs glomerular filtration by a direct ...
Chien-Lin Lu, Cai-Mei Zheng, Kuo-Cheng Lu, Min-Tser Liao, Kun-Lin Wu, Ming-Chieh Ma   +5 more
openaire   +3 more sources

Carbamoylated nail proteins as assessed by near-infrared analysis are associated with load of uremic toxins and mortality in hemodialysis patients [PDF]

, 2020
Carbamoylation is an important risk factor for accelerated atherogenesis and mortality in patients undergoing hemodialysis (HD). We intended to explore whether carbamoylation as assessed by near-infrared (NIR) analysis of nail proteins is associated with
De Bruyne, Sander, De Buyzere, Marc, Delanghe, Joris, Delanghe, Sigurd, Glorieux, Griet, Himpe, Jonas, Speeckaert, Marijn, Van Biesen, Wim   +7 more
core   +1 more source

Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3. [PDF]

PLoS ONE, 2013
The accumulated uremic toxins inhibit the expression of various renal transporters and this inhibition may further reduce renal function and subsequently cause the accumulation of uremic toxins.
Yasutoshi Akiyama, Koichi Kikuchi, Daisuke Saigusa, Takehiro Suzuki, Yoichi Takeuchi, Eikan Mishima, Yasuaki Yamamoto, Ayako Ishida, Daiki Sugawara, Daisuke Jinno, Hisato Shima, Takafumi Toyohara, Chitose Suzuki, Tomokazu Souma, Takashi Moriguchi, Yoshihisa Tomioka, Sadayoshi Ito, Takaaki Abe   +17 more
doaj   +1 more source

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB [PDF]

, 2013
BACKGROUND: Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD) patients, accelerating the progression of CKD.
Dilinaer Bolati, Fuyuhiko Nishijima, Hidehisa Shimizu, Maimaiti Yisireyili, Toshimitsu Niwa   +4 more
core   +1 more source

Hepatic microsomal metabolism of indole to indoxyl, a precursor of indoxyl sulfate [PDF]

European Journal of Drug Metabolism and Pharmacokinetics, 2001
The aim of our study was to determine which microsomal cytochrome P450 isozyme(s) were responsible for the microsomal oxidation of indole to indoxyl, an important intermediate in the information of the uremic toxin indoxyl sulfate. Indole was incubated together with an NADPH-generating system and rat liver microsomes.
Banoglu, Erden, Jha, G., King, Roberta S.   +2 more
openaire   +4 more sources

Indoxyl sulfate upregulates renal expression of icam-1 via production of ros and activation of nf-κb and p53 in proximal tubular cells

Kidney Research and Clinical Practice, 2012
Intercellular adhesion molecule 1 (ICAM-1) plays an important role in adhesion of monocytes/macrophages to injured tubulointerstitial tissue. The present study examined whether indoxyl sulfate, a uremic toxin, regulates renal expression of ICAM-1.
Hidehisa Shimizu, Toshimitsu Niwa
doaj   +1 more source

Efficient selective removal of uremic toxin precursor by olefin-linked covalent organic frameworks for nephropathy treatment

Nature Communications, 2023
Indoxyl sulfate is a protein-bound uremic toxin synthesized from indole that cannot be efficiently removed by the hemodialysis method and thus becomes a key risk factor for the progression of chronic kidney disease.
Jinxia Wei, Rui Li, Penghui Zhang, Haiqun Jin, Zhenjie Zhang, Yubo Li, Yao Chen   +6 more
doaj   +1 more source