Results 21 to 30 of about 6,816 (174)

p-Cresyl Sulfate and Indoxyl Sulfate in Hemodialysis Patients [PDF]

Clinical Journal of the American Society of Nephrology, 2009
Indoxyl sulfate and p-cresyl sulfate are important representatives of the protein-bound uremic retention solutes. Serum levels of p-cresyl sulfate and indoxyl sulfate are linked to cardiovascular outcomes and chronic kidney disease progression, respectively.
Björn K I, Meijers, Henriette, De Loor, Bert, Bammens, Kristin, Verbeke, Yves, Vanrenterghem, Pieter, Evenepoel   +5 more
openaire   +2 more sources

Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3. [PDF]

PLoS ONE, 2013
The accumulated uremic toxins inhibit the expression of various renal transporters and this inhibition may further reduce renal function and subsequently cause the accumulation of uremic toxins.
Yasutoshi Akiyama, Koichi Kikuchi, Daisuke Saigusa, Takehiro Suzuki, Yoichi Takeuchi, Eikan Mishima, Yasuaki Yamamoto, Ayako Ishida, Daiki Sugawara, Daisuke Jinno, Hisato Shima, Takafumi Toyohara, Chitose Suzuki, Tomokazu Souma, Takashi Moriguchi, Yoshihisa Tomioka, Sadayoshi Ito, Takaaki Abe   +17 more
doaj   +1 more source

Indoxyl sulfate upregulates renal expression of icam-1 via production of ros and activation of nf-κb and p53 in proximal tubular cells

Kidney Research and Clinical Practice, 2012
Intercellular adhesion molecule 1 (ICAM-1) plays an important role in adhesion of monocytes/macrophages to injured tubulointerstitial tissue. The present study examined whether indoxyl sulfate, a uremic toxin, regulates renal expression of ICAM-1.
Hidehisa Shimizu, Toshimitsu Niwa
doaj   +1 more source

Efficient selective removal of uremic toxin precursor by olefin-linked covalent organic frameworks for nephropathy treatment

Nature Communications, 2023
Indoxyl sulfate is a protein-bound uremic toxin synthesized from indole that cannot be efficiently removed by the hemodialysis method and thus becomes a key risk factor for the progression of chronic kidney disease.
Jinxia Wei, Rui Li, Penghui Zhang, Haiqun Jin, Zhenjie Zhang, Yubo Li, Yao Chen   +6 more
doaj   +1 more source

Phenyl sulfate, indoxyl sulfate and p-cresyl sulfate decrease glutathione level to render cells vulnerable to oxidative stress in renal tubular cells. [PDF]

PLoS ONE, 2018
In chronic kidney disease patients, oxidative stress is generally associated with disease progression and pathogenesis of its comorbidities. Phenyl sulfate is a protein-bound uremic solute, which accumulates in chronic kidney disease patients, but little
Takeo Edamatsu, Ayako Fujieda, Yoshiharu Itoh   +2 more
doaj   +1 more source

Unveiling the role of sex in the metabolism of indoxyl sulfate and apixaban. [PDF]

Sci Rep
Chronic Kidney Disease (CKD) is associated with heightened risk of thrombosis. Prescription of anticoagulants is key to manage it; however, CKD patients have shown an increased risk of bleeding under anticoagulation therapy compared to non-CKD patients. We hypothesized that the sex could modify the metabolism of indoxyl sulfate (IS), a uremic toxin and
Pina-Beltran B, Dimitrov D, McKay N, Giot M, Zdráhal Z, Potěšil D, Pustka V, Peinado-Izaguerri J, Saez-Rodriguez J, Poitevin S, Burtey S.   +10 more
europepmc   +4 more sources

The Uremic Toxicity of Indoxyl Sulfate and p-Cresyl Sulfate [PDF]

Journal of the American Society of Nephrology, 2014
A growing number of publications supports a biologic effect of the protein-bound uremic retention solutes indoxyl sulfate and p-cresyl sulfate. However, the use of unrealistically high free concentrations of these compounds and/or inappropriately low albumin concentrations may blur the interpretation of these results.
Raymond, Vanholder, Eva, Schepers, Anneleen, Pletinck, Evi V, Nagler, Griet, Glorieux   +4 more
openaire   +2 more sources

Impact of Indoxyl Sulfate on Progenitor Cell-Related Neovascularization of Peripheral Arterial Disease and Post-Angioplasty Thrombosis of Dialysis Vascular Access

Toxins, 2017
Patients with chronic kidney disease (CKD) have an increased risk of vascular disease, which is associated with considerable health care costs. Vascular disease in CKD differs clinically and pathobiologically from that in patients with normal renal ...
Chih-Cheng Wu, Szu-Chun Hung, Ko-Lin Kuo, Der-Cherng Tarng   +3 more
doaj   +1 more source

Uremic Toxins in Organ Crosstalk

Frontiers in Medicine, 2021
Many putative uremic toxins—like indoxyl sulfate, p-cresol sulfate, kynurenic acid, uric acid, and CMPF—are organic anions. Both inter-organ and inter-organismal communication are involved.
Jerome Lowenstein, Sanjay K. Nigam
doaj   +1 more source

Heritability and clinical determinants of serum indoxyl sulfate and p-cresyl sulfate, candidate biomarkers of the human microbiome enterotype.

PLoS ONE, 2014
BackgroundIndoxyl sulfate and p-cresyl sulfate are unique microbial co-metabolites. Both co-metabolites have been involved in the pathogenesis of accelerated cardiovascular disease and renal disease progression.
Liesbeth Viaene, Lutgarde Thijs, Yu Jin, Yanping Liu, Yumei Gu, Björn Meijers, Kathleen Claes, Jan Staessen, Pieter Evenepoel   +8 more
doaj   +1 more source