Results 31 to 40 of about 7,345 (172)
Microorganisms, 2022 The intestinal microbiota metabolic activity towards the available substrates generates myriad bacterial metabolites that may accumulate in the luminal fluid. Among them, indole and indole-related compounds are produced by specific bacterial species from
Naouel Tennoune +2 more
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Медицинская иммунология, 2023 Despite successful suppression of viral replication by antiretroviral drugs there is no significant increase in the number of peripheral CD4+T lymphocytes in some HIV-infected patients (immune nonresponse to therapy).
L. B. Korolevskaya +3 more
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The Production of p-Cresol Sulfate and Indoxyl Sulfate in Vegetarians Versus Omnivores [PDF]
Clinical Journal of the American Society of Nephrology, 2012 Summary Background and objectives The uremic solutes p-cresol sulfate (PCS) and indoxyl sulfate (IS) are generated by colon bacteria acting on food components that escape absorption in the small bowel. The production of these potentially toxic compounds may thus be influenced by diet.
Kajal P, Patel +4 more
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Lipids in Health and Disease, 2023 Background Urinary 3-indoxyl sulfate levels as well as fecal short chain fatty acid (SCFA) concentrations are surrogate markers for gut microbiota diversity.
Hauke Christian Tews +10 more
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Unveiling the role of sex in the metabolism of indoxyl sulfate and apixaban. [PDF]
Sci RepChronic Kidney Disease (CKD) is associated with heightened risk of thrombosis. Prescription of anticoagulants is key to manage it; however, CKD patients have shown an increased risk of bleeding under anticoagulation therapy compared to non-CKD patients. We hypothesized that the sex could modify the metabolism of indoxyl sulfate (IS), a uremic toxin and
Pina-Beltran B +10 more
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Indoxyl sulfate promotes apoptosis in cultured osteoblast cells [PDF]
BMC Pharmacology and Toxicology, 2013 Abstract Background Indoxyl sulfate (IS), an organic anion uremic toxin, promotes the progression of renal dysfunction. Some studies have suggested that IS inhibits osteoclast differentiation and suppresses parathyroid hormone (PTH)-stimulated intracellular cAMP production, decreases PTH receptor expression, and ...
Kim, Young-Hee +4 more
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Indoxyl sulfate, a uremic trigger for platelets [PDF]
Blood, 2017 In this issue of Blood , [Yang et al][1] explore the effects of the uremic toxin indoxyl sulfate (IS) triggering platelet hyperactivity in chronic kidney disease (CKD). In their mouse model of disease, the aging suppressor protein Klotho acts as an antidote for the toxin effects.[1][2] ![Figure ...
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Is Fluorescence Valid to Monitor Removal of Protein Bound Uremic Solutes in Dialysis? [PDF]
PLoS ONE, 2016 The aim of this study was to evaluate the contribution and removal dynamics of the main fluorophores during dialysis by analyzing the spent dialysate samples to prove the hypothesis whether the fluorescence of spent dialysate can be utilized for ...
Jürgen Arund +4 more
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Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate
Molecules, 2022 The deteriorating function of the kidneys in chronic kidney disease (CKD) is associated, among other things, with the retention of many unnecessary metabolic products in the body. Indoxyl sulfate (IS) belongs to the group of uremic toxins with a high protein binding affinity. Moreover, this compound can generate oxidative stress. We hypothesized that a
Anna Pieniazek +3 more
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International Journal of Nephrology and Renovascular Disease, 2022 Kullaya Takkavatakarn,1 Jeerath Phannajit,1 Suwasin Udomkarnjananun,1 Suri Tangchitthavorngul,1 Pajaree Chariyavilaskul,2,3 Patita Sitticharoenchai,4 Kearkiat Praditpornsilpa,1 Somchai Eiam-Ong,1 Paweena Susantitaphong1,5 1Division of Nephrology ...
Takkavatakarn K +8 more
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