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Associação entre indoxil sulfato e histomorfometria óssea em pacientes renais crônicos pré-diálise [PDF]
, 2014 Introduction: Experimental studies have suggested that indoxyl sulfate (IS), a protein-bound uremic toxin, may be involved in the development of renal osteodystrophy.
Barreto, Daniela Veit +9 more
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Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate
Molecules, 2022 The deteriorating function of the kidneys in chronic kidney disease (CKD) is associated, among other things, with the retention of many unnecessary metabolic products in the body. Indoxyl sulfate (IS) belongs to the group of uremic toxins with a high protein binding affinity. Moreover, this compound can generate oxidative stress. We hypothesized that a
Anna Pieniazek +3 more
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Gut microbiota in chronic kidney disease [PDF]
, 2016 La microflora intestinal mantiene una relación simbiótica con el huésped en condicionesnormales, sin embargo, su alteración se ha asociado recientemente con numerosas enfer-medades.En la enfermedad renal crónica (ERC) se ha descrito una disbiosis en la ...
Cases Amenós, Aleix +2 more
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Is Fluorescence Valid to Monitor Removal of Protein Bound Uremic Solutes in Dialysis? [PDF]
PLoS ONE, 2016 The aim of this study was to evaluate the contribution and removal dynamics of the main fluorophores during dialysis by analyzing the spent dialysate samples to prove the hypothesis whether the fluorescence of spent dialysate can be utilized for ...
Jürgen Arund +4 more
doaj +1 more source
Bisphenol A in chronic kidney disease [PDF]
, 2013 Phenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment and vascular damage. Bisphenol A (BPA) is a molecule with
Bosch, Ricardo J. +5 more
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Indoxyl sulfate, a uremic trigger for platelets [PDF]
Blood, 2017 In this issue of Blood , [Yang et al][1] explore the effects of the uremic toxin indoxyl sulfate (IS) triggering platelet hyperactivity in chronic kidney disease (CKD). In their mouse model of disease, the aging suppressor protein Klotho acts as an antidote for the toxin effects.[1][2] ![Figure ...
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Indoxyl sulfate induces complex redox alterations in mesangial cells [PDF]
American Journal of Physiology-Renal Physiology, 2006 Indoxyl sulfate is a protein metabolite that is concentrated in the serum of patients with chronic renal insufficiency. It also is a uremic toxin that has been implicated in the progression of chronic renal disease in rodent models. We have shown previously that mesangial cell redox status is related to activation of mitogen-activated protein kinases ...
Andrew K, Gelasco, John R, Raymond
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International Journal of Nephrology and Renovascular Disease, 2022 Kullaya Takkavatakarn,1 Jeerath Phannajit,1 Suwasin Udomkarnjananun,1 Suri Tangchitthavorngul,1 Pajaree Chariyavilaskul,2,3 Patita Sitticharoenchai,4 Kearkiat Praditpornsilpa,1 Somchai Eiam-Ong,1 Paweena Susantitaphong1,5 1Division of Nephrology ...
Takkavatakarn K +8 more
doaj
Uraemic toxins and new methods to control their accumulation : game changers for the concept of dialysis adequacy [PDF]
, 2015 The current concept of an adequate dialysis based only on the dialysis process itself is rather limited. We now have considerable knowledge of uraemic toxicity and improved tools for limiting uraemic toxin accumulation. It is time to make use of these. A
Glorieux, Griet, Tattersall, James
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Toxins, 2021 P-cresyl sulfate and indoxyl sulfate are strongly associated with cardiovascular events and all-cause mortality in chronic kidney disease (CKD). This randomized controlled trial was conducted to compare the effects between sevelamer and calcium carbonate
Kullaya Takkavatakarn +10 more
doaj +1 more source