Indoxyl sulfate in hemodialysis patients
Journal of Japanese Society for Dialysis Therapy, 1988 慢性血液透析患者血液中に蛋白結合して著明に増加しているインドキシル硫酸の高速液体クロマトグラフィー (HPLC) を用いた簡便な定量法の確立を試みた. 血清10μlをinternal-surface reversed-phase (ISRP) カラムを装着したHPLCにより分析した. 溶出ピークを乾固後, 二次イオンマススペクトロメトリー (SIMS) により測定したところ, 分子量が213と分かり, また, UVスペクトル, HPLCの保持時間もインドキシル硫酸と一致した.
Toshimitsu Niwa +3 more
openaire +2 more sources
Indoxyl sulfate induces apoptosis in mononuclear blood cells via mitochondrial pathway
Scientific Reports, 2023 The consequence of chronic kidney disease is the accumulation of metabolic products called uremic toxins in the body. Indoxyl sulfate (IS) is a toxin with a high affinity for proteins.
Anna Pieniazek +2 more
doaj +1 more source
Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure [PDF]
, 2015 Chronic kidney disease (CKD) is a major health problem worldwide. Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are highly protein-bound nephro-cardiovascular toxins, which are not efficiently removed through hemodialysis.
Chao, Pei-Dawn Lee +5 more
core +2 more sources
Gut-Microbiota-Metabolite Axis in Early Renal Function Decline.
PLoS ONE, 2015 IntroductionSeveral circulating metabolites derived from bacterial protein fermentation have been found to be inversely associated with renal function but the timing and disease severity is unclear.
Clara Barrios +10 more
doaj +1 more source
The Effects of Indoxyl Sulfate on Human Umbilical Cord-Derived Mesenchymal Stem Cells In Vitro
Cellular Physiology and Biochemistry, 2016 Background/Aims: Indoxyl sulfate, an important protein-bound uremic toxin, can damage stem cells, thus hampering stem cell-based regenerative medicine approaches targeting chronic kidney diseases (CKD). Human umbilical cord-derived mesenchymal stem cells
Wei Wang +9 more
doaj +1 more source
Association between Dental Scores and Saliva Uremic Toxins
Toxins, 2023 Dental health is frequently altered in patients with chronic kidney disease. We conducted a prospective study on dental health in CKD patients with a specific interest in the association between dental health issues and the accumulation of uremic toxins ...
Claire Rigothier +8 more
doaj +1 more source
Fluorescent Nanosensor for Indole‐3‐Propionic Acid Detection in Gut Health Monitoring
Advanced Healthcare Materials, EarlyView.This work introduces a fluorescent nanosensor system with two optical modalities for detection of indole‐3‐propionic acid (IPA) gut metabolite: (1) blue‐emitting cationic conjugated polyelectrolyte (CP3) and (2) near‐infrared (NIR)‐emitting CP3‐wrapped single‐walled carbon nanotube (SWNT).
Mervin Chun‐Yi Ang +15 more
wiley +1 more source
Toxins, 2014 Chronic kidney disease (CKD) has been considered a major risk factor for cardiovascular diseases. Although great advances have recently been made in the pathophysiology and treatment of cardiovascular diseases, CKD remains a major global health problem ...
Shunsuke Ito, Masayuki Yoshida
doaj +1 more source
The Production of p-Cresol Sulfate and Indoxyl Sulfate in Vegetarians Versus Omnivores [PDF]
Clinical Journal of the American Society of Nephrology, 2012 Summary Background and objectives The uremic solutes p-cresol sulfate (PCS) and indoxyl sulfate (IS) are generated by colon bacteria acting on food components that escape absorption in the small bowel. The production of these potentially toxic compounds may thus be influenced by diet.
Kajal P, Patel +4 more
openaire +2 more sources
The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial. [PDF]
PLoS ONE, 2016 UNLABELLED:The colonic microbial metabolism is a key contributor to uremic retention solutes accumulating in patients with CKD, relating to adverse outcomes and insulin resistance.
Ruben Poesen +8 more
doaj +1 more source