Results 61 to 70 of about 7,345 (172)

Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes

Cardiovascular Diabetology, 2020
Background Although an increased arterial stiffness has been associated with traditional coronary risk factors, the risk factors and pathology of arterial stiffness remain unclear.
Naoto Katakami, Kazuo Omori, Naohiro Taya, Shoya Arakawa, Mitsuyoshi Takahara, Taka-aki Matsuoka, Hiroshi Tsugawa, Masahiro Furuno, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura   +10 more
doaj   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression [PDF]

Nephrology Dialysis Transplantation, 2011
The fundamental insights into uraemic toxicity have evolved little since publication of the classical monograph by Cushny nearly a century ago [1]. Organic metabolites are still thought to substantially contribute to uremia (albeit urea might not be the culprit), yet evidence unequivocally demonstrating toxicity of any single uraemic constituent is ...
Björn K I, Meijers, Pieter, Evenepoel
openaire   +2 more sources

Quantitative, Targeted Analysis of Gut Microbiota Derived Metabolites Provides Novel Biomarkers of Early Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Biomolecules, 2023
Diabetic kidney disease (DKD) is one of the most debilitating complications of type 2 diabetes mellitus (T2DM), as it progresses silently to end-stage renal disease (ESRD). The discovery of novel biomarkers of early DKD becomes acute, as its incidence is
Lavinia Balint, Carmen Socaciu, Andreea Iulia Socaciu, Adrian Vlad, Florica Gadalean, Flaviu Bob, Oana Milas, Octavian Marius Cretu, Anca Suteanu-Simulescu, Mihaela Glavan, Silvia Ienciu, Maria Mogos, Dragos Catalin Jianu, Ligia Petrica   +13 more
doaj   +1 more source

Fecal Microbiota Transplantation and Microbiota‐Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 871-889, October 2026.
The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó, Dorina Korózs, Michal Bator, Krisztina Jeszenszky, Viktor Lakatos, László Gopcsa, Péter Reményi, János Sinkó   +7 more
wiley   +1 more source

Ligand binding to the FA3-FA4 cleft inhibits the esterase-like activity of human serum albumin. [PDF]

PLoS ONE, 2015
The hydrolysis of 4-nitrophenyl esters of hexanoate (NphOHe) and decanoate (NphODe) by human serum albumin (HSA) at Tyr411, located at the FA3-FA4 site, has been investigated between pH 5.8 and 9.5, at 22.0°C.
Paolo Ascenzi, Loris Leboffe, Alessandra di Masi, Viviana Trezza, Gabriella Fanali, Magda Gioia, Massimo Coletta, Mauro Fasano   +7 more
doaj   +1 more source

Multi‐omics–driven precision medicine

iMeta, Volume 5, Issue 5, October 2026.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Levels of indoxyl sulfate are associated with severity of coronary atherosclerosis

Clinical and Investigative Medicine, 2013
Purpose Indoxyl sulfate (IS) is linked to endothelial damage, NF-αB activation and induced development of atherosclerosis. The purpose of this study was to investigate the relationship between serum IS levels and the severity of coronary artery stenosis.
Chia-Chang, Hsu, Yung-Chuan, Lu, Cheng-An, Chiu, Teng-Hung, Yu, Wei-Chin, Hung, Chao-Ping, Wang, Li-Fen, Lu, Fu-Mei, Chung, Yau-Jiunn, Lee, I-Ting, Tsai   +9 more
openaire   +3 more sources

Chronic Kidney Disease Is Associated With Increased Cardiac Corin Expression But Decreased Proatrial Natriuretic Peptide Conversion Activity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease. Corin converts proatrial natriuretic peptide into its active form after being activated by PCSK6 (proprotein convertase subtilisin/kexin type 6 ...
Shang‐Feng Yang, Szu‐Yuan Li, Feng‐Yen Lin, Tsung‐Han Hsieh, Po‐Hsun Huang, Shing‐Jong Lin   +5 more
doaj   +1 more source

Maternal microbiota shapes brain and neuroendocrine development in piglets

iMeta, Volume 5, Issue 5, October 2026.
Using germ‐free and maternal microbiota‐transplanted piglets, we constructed an integrated multi‐organ atlas combining snRNA‐seq, Stereo‐seq, intestinal transcriptomics, and metabolomics. Maternal microbiota transplantation was associated with neuronal and glial remodeling, altered neuron–glia communication involving NRG1/3–ERBB4 signaling, trends ...
Leli Wang, Chao Yan, Lei Li, Yuankun Deng, Hua Shao, Kuo Long, Cimin Long, Yuanyuan Zhu, Meiqing Chen, Jialu Huang, Jinghua Jiang, Ziyi Lin, Yunying Yao, Tao Yang, Wenbin Guo, Liangpeng Ge, Jing Sun, Yuchun Ding, Zuohua Liu, Mingzhu Yin, Yulong Yin   +20 more
wiley   +1 more source