Results 61 to 70 of about 6,816 (174)

Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes

Cardiovascular Diabetology, 2020
Background Although an increased arterial stiffness has been associated with traditional coronary risk factors, the risk factors and pathology of arterial stiffness remain unclear.
Naoto Katakami, Kazuo Omori, Naohiro Taya, Shoya Arakawa, Mitsuyoshi Takahara, Taka-aki Matsuoka, Hiroshi Tsugawa, Masahiro Furuno, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura   +10 more
doaj   +1 more source

Quantitative, Targeted Analysis of Gut Microbiota Derived Metabolites Provides Novel Biomarkers of Early Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Biomolecules, 2023
Diabetic kidney disease (DKD) is one of the most debilitating complications of type 2 diabetes mellitus (T2DM), as it progresses silently to end-stage renal disease (ESRD). The discovery of novel biomarkers of early DKD becomes acute, as its incidence is
Lavinia Balint, Carmen Socaciu, Andreea Iulia Socaciu, Adrian Vlad, Florica Gadalean, Flaviu Bob, Oana Milas, Octavian Marius Cretu, Anca Suteanu-Simulescu, Mihaela Glavan, Silvia Ienciu, Maria Mogos, Dragos Catalin Jianu, Ligia Petrica   +13 more
doaj   +1 more source

Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients

Hemodialysis International, EarlyView.
ABSTRACT Introduction Tenapanor, a minimally absorbed intestinal NHE3 inhibitor approved for hyperphosphatemia in dialysis, lowers phosphate and reduces intestinal sodium absorption. Its sodium–water signal may have implications beyond phosphate but remains poorly separated from diarrhea‐mediated losses and dialysis prescription artifacts. Methods This
Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior   +8 more
wiley   +1 more source

Ligand binding to the FA3-FA4 cleft inhibits the esterase-like activity of human serum albumin. [PDF]

PLoS ONE, 2015
The hydrolysis of 4-nitrophenyl esters of hexanoate (NphOHe) and decanoate (NphODe) by human serum albumin (HSA) at Tyr411, located at the FA3-FA4 site, has been investigated between pH 5.8 and 9.5, at 22.0°C.
Paolo Ascenzi, Loris Leboffe, Alessandra di Masi, Viviana Trezza, Gabriella Fanali, Magda Gioia, Massimo Coletta, Mauro Fasano   +7 more
doaj   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Chronic Kidney Disease Is Associated With Increased Cardiac Corin Expression But Decreased Proatrial Natriuretic Peptide Conversion Activity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease. Corin converts proatrial natriuretic peptide into its active form after being activated by PCSK6 (proprotein convertase subtilisin/kexin type 6 ...
Shang‐Feng Yang, Szu‐Yuan Li, Feng‐Yen Lin, Tsung‐Han Hsieh, Po‐Hsun Huang, Shing‐Jong Lin   +5 more
doaj   +1 more source

Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 465-474, August 2026.
Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur, Jashvant D. Unadkat, Emily E. Fay, Nina Isoherranen, Mary F. Hebert   +4 more
wiley   +1 more source

Uremic toxicity of indoxyl sulfate.

Nagoya journal of medical science, 2010
Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD) patients. A part of the dietary protein-derived tryptophan is metabolized into indole by tryptophanase in intestinal bacteria. Indole is absorbed into the blood from the intestine, and is metabolized to indoxyl sulfate in the liver.
openaire   +2 more sources

The metabolic‐immune hub: Dual roles of indoleamine 2,3‐dioxygenase in the acute kidney injury‐to‐chronic kidney disease transition and therapeutic perspectives

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
1. Indoleamine 2,3‐dioxygenase (IDO) acts as a time‐dependent metabolic–immune switch in the acute kidney injury‐to‐chronic kidney disease transition, protective early but pathogenic when sustained. 2. Early protection (regulatory T cell expansion, M2 polarisation and ferroptosis suppression) gives way to general control nonderepressible 2‐driven ...
Ziyi Qiu, Binbin Pan
wiley   +1 more source

Amino acid homeostasis in the kidney: Physiological roles and pathological dysregulation

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Amino acids are fundamental to life as protein building blocks and key regulators of metabolism and signaling. The kidney plays a critical, yet underappreciated, role in amino acid homeostasis through three interconnected pillars: selective glomerular filtration, efficient tubular reabsorption, and metabolic processing, which includes de novo ...
Shuo Liu, Caifeng Shi, Yang Zhou, Chunsun Dai   +3 more
wiley   +1 more source