Results 71 to 80 of about 7,345 (172)

Uremic toxicity of indoxyl sulfate.

Nagoya journal of medical science, 2010
Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD) patients. A part of the dietary protein-derived tryptophan is metabolized into indole by tryptophanase in intestinal bacteria. Indole is absorbed into the blood from the intestine, and is metabolized to indoxyl sulfate in the liver.
openaire   +2 more sources

Halting the Progression of Acute Kidney Injury: A Tubular‐Inspired Reusable Detoxifier Against Protein‐Bound Uremic Toxins and Oxidative Stress

SusMat, Volume 6, Issue 5, October 2026.
This graphical ToC illustrates a tubular‐inspired detoxifier (SDCMs–DS) that halts acute kidney injury progression. Inspired by proximal tubular epithelial cells (PTECs), the biomimetic design combines dissociation‐adsorption clearance of protein‐bound uremic toxins (PBUTs) with antioxidant protection. During hemoperfusion, danshensu (DS) released from
Yilin Wang, Jiahao Liang, Xijing Yang, Xin Song, Yujie Xiao, Xiran Zhou, Hongyu Xiang, Shujing Wang, Shengjun Cheng, Xianda Liu, Yu Chen, Weifeng Zhao, Changsheng Zhao   +12 more
wiley   +1 more source

Impact of Indoxyl Sulfate on Coronary Plaques in Patients on Hemodialysis

International Heart Journal, 2018
Serum indoxyl sulfate (IS; a uremic toxin) levels, which are significantly higher in patients with chronic kidney disease, including those undergoing hemodialysis, than in the robust, are associated with both cardiovascular disease (CVD) and CVD-related mortality.
Asami, Masahiko, Tanabe, Kengo, Ito, Shunsuke, Yoshida, Eri, Aoki, Jiro, Tanimoto, Shuzou, Horiuchi, Yu, Yoshida, Masayuki   +7 more
openaire   +3 more sources

Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease

VIEW, Volume 7, Issue 5, October 2026.
This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin, Lijie Ma, Yuqing Yuan, Kaiyi Zhu, Zhaohui Tong, Qianmei Sun   +5 more
wiley   +1 more source

Potential Roles of Escherichia coli in IgA Nephropathy: Evidence, Mechanistic Hypotheses and Microbiota‐Targeted Strategies

Microbial Biotechnology, Volume 19, Issue 10, October 2026.
Schematic diagram of the core pathogenic pathway by which E. coli drives IgAN.E. coli expansion in IgAN is driven by host, environmental and ecological factors, and promotes disease progression via two core pathways: LPS‐induced immune activation and pyroptosis, and metabolite‐mediated remote regulation, leading to Gd‐IgA1 overproduction, mesangial ...
Yuxin Liu, Xiaoxuan Ning, Yichen Liu, Zixian Yu, Jie Liu, Xiaoqin Xu, Jin Zhao, Shiren Sun   +7 more
wiley   +1 more source

Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients

Hemodialysis International, Volume 30, Issue 4, Page 689-697, October 2026.
ABSTRACT Introduction Tenapanor, a minimally absorbed intestinal NHE3 inhibitor approved for hyperphosphatemia in dialysis, lowers phosphate and reduces intestinal sodium absorption. Its sodium–water signal may have implications beyond phosphate but remains poorly separated from diarrhea‐mediated losses and dialysis prescription artifacts. Methods This
Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior   +8 more
wiley   +1 more source

Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance [PDF]

Journal of the American Society of Nephrology, 2019
Significance Statement Vascular calcification contributes to high cardiovascular mortality in patients with CKD. Although research findings have suggested an association between the uremic toxins indoxyl sulfate and p-cresyl sulfate and cardiovascular disease, direct evidence has been lacking.
Opdebeeck, Britt, Maudsley, Stuart, Azmi, Abdelkrim, De Mare, Annelies, De Leger, Wout, Meijers, Bjorn, Verhulst, Anja, Evenepoel, Pieter, D'Haese, Patrick C., Neven, Ellen   +9 more
openaire   +3 more sources

Early Outpatient bFGF‐Based Wound Care for Foot Lesions in Haemodialysis Patients: A Real‐World Stepwise Limb‐Salvage Strategy From Japan

International Wound Journal, Volume 23, Issue 10, October 2026.
ABSTRACT Haemodialysis patients face a markedly elevated risk of foot lesions because of coexisting diabetes mellitus (DM), peripheral arterial disease (PAD) and uremia‐related impairment of wound healing. Structured outpatient strategies and the optimal place of basic fibroblast growth factor (bFGF) within a stepwise algorithm remain poorly defined ...
Sadanori Akita, Motoyuki Tamaki, Hiroyuki Hayashi, Masanori Tamaki, Masaharu Tamaki   +4 more
wiley   +1 more source

Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions. Traditional Chinese medicine (TCM) formulas, characterized by multi‐component, multi‐target, and multi‐pathway ...
Chenrong Jin, Ding Du, Xiaorui Yu, Xiaoyan Ji, Xiuyun Zhang, Anning Li, Shuang Zu, Bo Qu, Daqing Zhao, Dianpeng Wu, Meichen Liu   +10 more
wiley   +1 more source

Quercetin Suppresses AOM/DSS-Induced Colon Carcinogenesis through Its Anti-Inflammation Effects in Mice

Journal of Immunology Research, 2020
Colorectal cancer (CRC) is the fourth leading cause of tumor-related deaths worldwide. In this study, we explored the in vivo effects of quercetin, a plant flavonol from the flavonoid group of polyphenols with antioxidant effects, on colon carcinogenesis
Rui Lin, Meiyu Piao, Yan Song, Chunyan Liu   +3 more
doaj   +1 more source