Results 71 to 80 of about 11,454 (213)

Effects of Maternal Low Protein Diet on Expression of Drug Transporters in the Blood-Brain Barrier of Adult Offspring [PDF]

, 2012
Adverse uterine environment, manifested as low birth weight (LBW), has been shown to predispose individuals to hypertension, diabetes, and obesity by mechanisms that are just beginning to be understood.
Hastings, Bonnie L.
core   +1 more source

Does canine inflammatory bowel disease influence gut microbial profile and host metabolism? [PDF]

, 2016
Background: Inflammatory bowel disease (IBD) refers to a diverse group of chronic gastrointestinal diseases, and gut microbial dysbiosis has been proposed as a modulating factor in its pathogenesis.
Bosch, Guido, Eeckhaut, Venessa, Hesta, Myriam, Janssens, Geert, Junius, Greet, Liu, Daisy, Niu, Yufeng, Ribeiro Alves Lourenço, Marta, Van de Maele, Isabel, Van de Wiele, Tom, Van Immerseel, Filip, Verbrugghe, Adronie, Wuyts, Brigitte, Xu, Jia   +13 more
core   +2 more sources

Metabolomics Study of Urine in Autism Spectrum Disorders Using a Multiplatform Analytical Methodology [PDF]

, 2015
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with no clinical biomarker. Aims of this study were to characterize a metabolic signature of ASD, and to evaluate multi-platform analytical methodologies in order to develop predictive tools
American Psychiatric Association, American Psychiatric Association, Binta Diémé, Christian R Andres, Cinzia Bocca, De Jonge W. J., Eriksson L., Frédérique Bonnet-Brilhault, Gabriele Tripi, Huang Y., Hélène Blasco, James S. J., Joëlle Malvy, Lambert M. A., Lydie Nadal-Desbarats, Patrick Emond, Sylvie Mavel, World Health Organization   +17 more
core   +7 more sources

The Role of Indoxyl Sulfate in Exacerbating Colorectal Cancer During Chronic Kidney Disease Progression: Insights into the Akt/β-Catenin/c-Myc and AhR/c-Myc Pathways in HCT-116 Colorectal Cancer Cells

Toxins
Epidemiological studies suggest an increased risk of colorectal cancer (CRC) aggravation in patients with chronic kidney disease (CKD). Our previous study demonstrated that indoxyl sulfate, a uremic toxin whose concentration increases with CKD ...
Yu Ichisaka, Chihiro Takei, Kazuma Naito, Manami Higa, Shozo Yano, Toshimitsu Niwa, Hidehisa Shimizu   +6 more
doaj   +1 more source

Chronic kidney disease and fibrosis : the role of uremic retention solutes [PDF]

, 2015
Chronic kidney disease (CKD) is a major global health concern, and the uremic state is highly associated with fibrogenesis in several organs and tissues.
Glorieux, Griet, Mutsaers, Henricus AM, Olinga, Peter, Stribos, Elisabeth GD, Vanholder, Raymond   +4 more
core   +3 more sources

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source

Quantitative, Targeted Analysis of Gut Microbiota Derived Metabolites Provides Novel Biomarkers of Early Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Biomolecules, 2023
Diabetic kidney disease (DKD) is one of the most debilitating complications of type 2 diabetes mellitus (T2DM), as it progresses silently to end-stage renal disease (ESRD). The discovery of novel biomarkers of early DKD becomes acute, as its incidence is
Lavinia Balint, Carmen Socaciu, Andreea Iulia Socaciu, Adrian Vlad, Florica Gadalean, Flaviu Bob, Oana Milas, Octavian Marius Cretu, Anca Suteanu-Simulescu, Mihaela Glavan, Silvia Ienciu, Maria Mogos, Dragos Catalin Jianu, Ligia Petrica   +13 more
doaj   +1 more source

Uremic solutes and risk of end stage renal disease in type 2 diabetes [PDF]

, 2014
Here we studied plasma metabolomic profiles as determinants of progression to ESRD in patients with Type 2 diabetes (T2D). This nested case-control study evaluated 40 cases who progressed to ESRD during 8-12 years of follow-up and 40 controls who ...
Berry, Gerard T, Bonventre, Joseph V, Byun, Jaeman, Huang, Xiaoping, Karoly, Edward D, Kensicki, Elizabeth M, Krolewski, Andrzej S, Mathew, Anna V, Meyer, Timothy W, Mohney, Robert P, Niewczas, Monika A, Pennathur, Subramaniam, Sirich, Tammy L, Skupien, Jan, Smiles, Adam, Walker, Walker, Warram, James H   +16 more
core   +1 more source

An In Vitro System for Studying Toxin Transport Across Hemodialysis Membranes

Artificial Organs, EarlyView.
Development of an in vitro hemodialysis (HD) system based on mini dialyzers for evaluating hemodialysis membranes under physiologically relevant conditions. ABSTRACT Background Healthy kidneys regulate acid–base balance and electrolytes, produce hormones, and clear excess fluids and uremic toxins.
M. Torrents‐Yeste, D. Ramada, O. E. M. ter Beek, F. Pel, J. de Vries, B. H. Lentferink, K. G. F. Gerritsen, D. Stamatialis   +7 more
wiley   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source