Results 71 to 80 of about 6,816 (174)
Analysis &Sensing, Volume 6, Issue 4, July 2026.This study presents a multimatrix untargeted metabolomics analysis of fecal, plasma, and urine samples from individuals at high risk for pancreatic cancer development. Integrated multivariate and cofactor‐adjusted models were applied to characterize cross‐matrix metabolomic associations, incorporating pancreatic magnetic resonance imaging data, sex ...
Vladyslav Dovhalyuk +6 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 7, July 2026.Repetitive transcranial magnetic stimulation (rTMS) ameliorates chronic unpredictable mild stress (CUMS)‐induced depressive‐like behaviors in mice by modulating key tryptophan metabolism pathways, as evidenced by the restoration of serotonin levels and reduction of neuroactive metabolites.
Gao Yuan +8 more
wiley +1 more source
Levels of indoxyl sulfate are associated with severity of coronary atherosclerosis
Clinical and Investigative Medicine, 2013 Purpose Indoxyl sulfate (IS) is linked to endothelial damage, NF-αB activation and induced development of atherosclerosis. The purpose of this study was to investigate the relationship between serum IS levels and the severity of coronary artery stenosis.
Chia-Chang, Hsu +9 more
openaire +3 more sources
Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance [PDF]
Journal of the American Society of Nephrology, 2019 Significance Statement Vascular calcification contributes to high cardiovascular mortality in patients with CKD. Although research findings have suggested an association between the uremic toxins indoxyl sulfate and p-cresyl sulfate and cardiovascular disease, direct evidence has been lacking.
Opdebeeck, Britt +9 more
openaire +3 more sources
Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content
Food Safety and Health, Volume 4, Issue 3, Page 684-696, July 2026.By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao +8 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.Uremic cardiomyopathy (UCM) is a life‐threatening complication of uremia. We find that extracellular vesicle (EV)‐miR‐744‐5p mediates peripheral blood mononuclear cell (PBMC)‐cardiomyocyte communication in UCM. Salvianolic acid B treats UCM by modulating EV‐miR‐744‐5p expression.
Ziran Wang +17 more
wiley +1 more source
Journal of Immunology Research, 2020 Colorectal cancer (CRC) is the fourth leading cause of tumor-related deaths worldwide. In this study, we explored the in vivo effects of quercetin, a plant flavonol from the flavonoid group of polyphenols with antioxidant effects, on colon carcinogenesis
Rui Lin +3 more
doaj +1 more source
An In Vitro System for Studying Toxin Transport Across Hemodialysis Membranes
Artificial Organs, Volume 50, Issue 7, Page 988-1006, July 2026.Development of an in vitro hemodialysis (HD) system based on mini dialyzers for evaluating hemodialysis membranes under physiologically relevant conditions. ABSTRACT Background Healthy kidneys regulate acid–base balance and electrolytes, produce hormones, and clear excess fluids and uremic toxins.
M. Torrents‐Yeste +7 more
wiley +1 more source
Impact of Indoxyl Sulfate on Coronary Plaques in Patients on Hemodialysis
International Heart Journal, 2018 Serum indoxyl sulfate (IS; a uremic toxin) levels, which are significantly higher in patients with chronic kidney disease, including those undergoing hemodialysis, than in the robust, are associated with both cardiovascular disease (CVD) and CVD-related mortality.
Asami, Masahiko +7 more
openaire +3 more sources
Neurogastroenterology &Motility, Volume 38, Issue 7, July 2026.We previously showed that molecules solubilized in filter‐sterilized stool filtrates (postbiotic stool filtrates; PSFs) of mice fed a high‐fat diet (HFD) may have a role in triggering damage to the enteric nervous system and gut dysmotility before the onset of T2D symptoms. To translate these results, we studied the effects of PSFs from male and female
Peter F. Voller +14 more
wiley +1 more source