Results 91 to 100 of about 11,454 (213)

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1057-1069, April 2026.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Differential Analysis of IAA Anabolism Pathway Based on Bacillus cereus, Bacillus subtilis and Bacillus safensis Genome

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Three Bacillus species isolated from Platycladus orientalis rhizosphere in Taihang Mountains: Bacillus cereus has 3 IAA synthesis pathways (TAM, IAM, IPyA); Bacillus subtilis has IAM/IPyA; and Bacillus safensis only has IPyA (via whole‐genome sequencing).
Dongyue Hou, Xuejie Zhai, Kezhong Zhang, Jinteng Cui   +3 more
wiley   +1 more source

Acid–Base Dysregulation Links Aging Metabolism to Frailty

Aging Cell, Volume 25, Issue 4, April 2026.
Our Metabolic Buffer Model posits that chronic acid load from aging and accumulated stressors depletes total acid buffer reserve, disrupting intersystem crosstalk. This hidden homeostatic erosion drives clinical frailty and underlies homeostatic failure during stress, unifying Rockwood's deficit accumulation and Fried's phenotype models.
Wan‐Hui Liao, Wolfgang Langhans, Maciej Henneberg   +2 more
wiley   +1 more source

Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability [PDF]

, 2001
Although it was originally believed that thyroid hormones enter target cells by passive diffusion, it is now clear that cellular uptake is effected by carrier-mediated processes.
Docter, R. (Roel), Friesema, E.C.H. (Edith), Hennemann, G. (George), Jong, M. (Marion) de, Krenning, E.P. (Eric), Visser, T.J. (Theo)   +5 more
core   +3 more sources

Current Trends in the Epidemiology of Obesity and the Association Between Obesity and Metabolic Liver Disease (MASLD/MASH)

Diabetes, Obesity and Metabolism, Volume 28, Issue S2, Page 3-18, April 2026.
ABSTRACT Excess adiposity and obesity are increasingly prevalent, with incidence rising in many parts of the world; both trigger a state of metabo‐inflammation in adipose tissue, creating a systemic milieu characterised by insulin resistance and pro‐inflammatory and fibrogenic states. Along with systemic inflammatory cues, perturbations in systemic and
Mirjana Grocic, Madison Nguyen, Arun J. Sanyal   +2 more
wiley   +1 more source

Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to DSS‐Induced Colitis

Immunology, Volume 177, Issue 4, Page 766-783, April 2026.
C57BL/6 mice from Charles River Laboratories (CR) have enhanced mucosal immune action relative to C57BL/6 mice from Jackson Laboratories (JAX). CR mice are more susceptible to severe DSS‐induced colitis than JAX mice. Co‐housing transfers colitis susceptibility from CR mice to JAX mice.
Jessica M. Till, Orion D. Brock, Elyza A. Do, Morgan J. Engelhart, Robert W. P. Glowacki, Shaomin Hu, Ansel Hsiao, Ina Nemet, Philip P. Ahern   +8 more
wiley   +1 more source

Quercetin Suppresses AOM/DSS-Induced Colon Carcinogenesis through Its Anti-Inflammation Effects in Mice

Journal of Immunology Research, 2020
Colorectal cancer (CRC) is the fourth leading cause of tumor-related deaths worldwide. In this study, we explored the in vivo effects of quercetin, a plant flavonol from the flavonoid group of polyphenols with antioxidant effects, on colon carcinogenesis
Rui Lin, Meiyu Piao, Yan Song, Chunyan Liu   +3 more
doaj   +1 more source

Maintenance of Carnitine Homeostasis as a Therapeutic Strategy to Attenuate Cisplatin‐Induced Acute Kidney Injury

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Acute kidney injury (AKI) has emerged as a significant global public health concern due to its high morbidity and mortality rates. Cisplatin, a highly effective and widely used chemotherapeutic agent, is often limited in clinical application by its nephrotoxicity, particularly AKI.
Mingkang Zhang, Yazhi Wang, Xiujuan Wang, Yan Zhou, Yanrong Ma, Xin'an Wu   +5 more
wiley   +1 more source

Free and protein-bound tryptophan in serum of untreated patients with chronic renal failure [PDF]

, 1993
Free and protein-bound tryptophan in serum of untreated patients with chronic renal failure. In fasting sera from 46 untreated patients with chronic renal failure and in 22 normal subjects, non-protein-bound tryptophan, F, was separated by pH-controlled ...
Hill, Sylvia B., Walser, Mackenzie
core   +1 more source

Gut Microbiota–Metabolism Axis Shapes the Individual Metabolic Phenotype of Different Microbiota‐Accessible Carbohydrates

Food Frontiers, Volume 7, Issue 2, March 2026.
Specific MAC bioactivities are associated with gut biotransformation. ABSTRACT Increasing the intake of microbiota‐accessible carbohydrates (MACs) has emerged as a promising nutritional strategy for preventing metabolic diseases. However, the consistency of their beneficial effects remains unclear, hindering their optimized application.
Na‐Na Zhang, Guo‐Quan Shao, Xin‐Xin Guo, Jing‐Yi Zhang, Yang Li, Li‐Li Wang, Yue Zhang, Feng‐Zhong Wang, Li‐Tao Tong   +8 more
wiley   +1 more source