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Switching from febuxostat to dotinurad, a novel selective urate reabsorption inhibitor, may substantially reduce serum urate levels, through URAT1 inhibition, potentially without adversely affecting ABCG2 function: findings from the SWITCH SURI study

Frontiers in Endocrinology
BackgroundDotinurad is a novel selective urate transporter 1 (URAT1) inhibitor recently introduced in Japan. This study aims to evaluate the efficacy and safety of dotinurad in hyperuricemic patients with type 2 diabetic kidney disease by comparing serum
Takeshi Osonoi +8 more
doaj +1 more source

Trimethylamine N-oxide, S-equol, and indoxyl sulfate inflammatory microbiota players in ocular Behçet’s disease

Türk Biyokimya Dergisi
The aims of the study were to assess the levels of serum TMAO, S-equol, and indoxyl sulfate in subjects with ocular active Behçet’s disease (OABD) and ocular inactive Behçet’s disease (OIBD).
Arslan Sermal +3 more
doaj +1 more source

Uremic Toxicity of Indoxyl Sulfate

Uremic Toxicity of Indoxyl Sulfate
Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD) patients.A part of the dietary protein-derived tryptophan is metabolized into indole by tryptophanase in intestinal bacteria. Indole is absorbed into the blood from the intestine, and is metabolized to indoxyl sulfate in the liver.
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Analytical and clinical validation of a competitive ELISA for serum indoxyl sulfate and its clinical association with chronic kidney disease risk stratification. [PDF]