Results 81 to 90 of about 11,454 (213)

Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes

Cardiovascular Diabetology, 2020
Background Although an increased arterial stiffness has been associated with traditional coronary risk factors, the risk factors and pathology of arterial stiffness remain unclear.
Naoto Katakami, Kazuo Omori, Naohiro Taya, Shoya Arakawa, Mitsuyoshi Takahara, Taka-aki Matsuoka, Hiroshi Tsugawa, Masahiro Furuno, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura   +10 more
doaj   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Ligand binding to the FA3-FA4 cleft inhibits the esterase-like activity of human serum albumin. [PDF]

PLoS ONE, 2015
The hydrolysis of 4-nitrophenyl esters of hexanoate (NphOHe) and decanoate (NphODe) by human serum albumin (HSA) at Tyr411, located at the FA3-FA4 site, has been investigated between pH 5.8 and 9.5, at 22.0°C.
Paolo Ascenzi, Loris Leboffe, Alessandra di Masi, Viviana Trezza, Gabriella Fanali, Magda Gioia, Massimo Coletta, Mauro Fasano   +7 more
doaj   +1 more source

Chronic Kidney Disease Is Associated With Increased Cardiac Corin Expression But Decreased Proatrial Natriuretic Peptide Conversion Activity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease. Corin converts proatrial natriuretic peptide into its active form after being activated by PCSK6 (proprotein convertase subtilisin/kexin type 6 ...
Shang‐Feng Yang, Szu‐Yuan Li, Feng‐Yen Lin, Tsung‐Han Hsieh, Po‐Hsun Huang, Shing‐Jong Lin   +5 more
doaj   +1 more source

Chronic Kidney Disease Increases Cerebral Microbleeds in Mouse and Man. [PDF]

, 2020
Brain microbleeds are increased in chronic kidney disease (CKD) and their presence increases risk of cognitive decline and stroke. We examined the interaction between CKD and brain microhemorrhages (the neuropathological substrate of microbleeds) in ...
Bangash, Maria, Cribbs, David H, Fisher, Mark, Floriolli, David, Lau, Wei Ling, Lertpanit, Long, Naqvi, Sameen, Nunes, Ane CF, Paganini-Hill, Annlia, Savoj, Javad, Shah, Krunal, Vasilevko, Vitaly, Vaziri, Nosratola D, Yao, Zhihui   +13 more
core  

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Triggering of suicidal erythrocyte death by uremic toxin indoxyl sulfate [PDF]

BMC Nephrology, 2013
Abstract Background Anemia in end stage renal disease is attributed to impaired erythrocyte formation due to erythropoietin and iron deficiency. On the other hand, end stage renal disease enhances eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and phosphatidylserine-exposure at the ...
Ahmed, Mohamed Siyabeldin E, Abed, Majed, Voelkl, Jakob, Lang, Florian   +3 more
openaire   +2 more sources

Association between protein-bound uremic toxins and asymptomatic cardiac dysfunction in patients with chronic kidney disease [PDF]

, 2018
Although the relationship between protein-bound uremic toxins (PBUTs) and cardiac structure and cardiac mortality in chronic kidney disease (CKD) has been studied in the past, the association between cardiac dysfunction and PBUTs has not yet been studied.
Chinnappa, Shanmugakumar, Glorieux, Griet, Mooney, Andrew, Tu, Yu-Kang, Vanholder, Raymond, Yeh, Yi Chun   +5 more
core   +2 more sources

A Case Study and Review of the Literature on IgA Nephropathy in Crohn's Disease

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT IgA nephropathy (IgAN) is the most frequently reported glomerular disease associated with inflammatory bowel disease (IBD), particularly Crohn's disease (CD), although pediatric cases remain rare. We report IgAN in a 16‐year‐old male with CD following intestinal surgery and during long‐term infliximab therapy, with renal impairment occurring ...
Giovanna Fernanda Vazzana, Alessia Romano, Chiara Casuscelli, Alberto La Spada, Domenico Santoro, Roberto Chimenz, Claudio Romano   +6 more
wiley   +1 more source

Serum Indoxyl Sulfate Associates with Postangioplasty Thrombosis of Dialysis Grafts [PDF]

Journal of the American Society of Nephrology, 2016
Hemodialysis vascular accesses are prone to recurrent stenosis and thrombosis after endovascular interventions.In vitro data suggest that indoxyl sulfate, a protein-bound uremic toxin, may induce vascular dysfunction and thrombosis. However, there is no clinical evidence regarding the role of indoxyl sulfate in hemodialysis vascular access.
Chih-Cheng, Wu, Mu-Yang, Hsieh, Szu-Chun, Hung, Ko-Lin, Kuo, Tung-Hu, Tsai, Chao-Lun, Lai, Jaw-Wen, Chen, Shing-Jong, Lin, Po-Hsun, Huang, Der-Cherng, Tarng   +9 more
openaire   +2 more sources