Results 81 to 90 of about 6,816 (174)

The Toxic Filter: Chronic Kidney Disease Drives Neuro‐Psychiatric Toxicity and Agitation in Sepsis Survivors Aged ≥ 90 Years: A Retrospective Cohort Study Using the National Database of Japan

Psychogeriatrics, Volume 26, Issue 4, July 2026.
ABSTRACT Background In sepsis survivors aged ≥ 90 years, physiological reserve defines recovery. We previously identified liver dysfunction as protective (‘liver paradox’) and rehabilitation as a trigger for mental decline. Here, we hypothesised a ‘metabolic dichotomy’, where chronic kidney disease (CKD) damages the brain by accumulating neurotoxins ...
Yuichiro Shimoyama, Noriko Kadono, Osamu Umegaki   +2 more
wiley   +1 more source

The double‐edged sword of endoplasmic reticulum stress in uremic sarcopenia through myogenesis perturbation

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background Sarcopenia is the age‐related degeneration characterized with the decline of skeletal muscle mass, strength, and function. The imbalance of protein synthesis and degradation which jeopardizes immune, hormone regulation, and muscle‐motor neuron
Jia‐Rong Jheng, Yuan‐Siao Chen, Un Iong Ao, Ding‐Cheng Chan, Jenq‐Wen Huang, Kuang‐Yu Hung, Der‐Cheng Tarng, Chih‐Kang Chiang   +7 more
doaj   +1 more source

Protein-Bound Uremic Toxins: New Insight from Clinical Studies

Toxins, 2011
The uremic syndrome is attributed to the progressive retention of a large number of compounds which, under normal conditions, are excreted by healthy kidneys. The compounds are called uremic toxins when they interact negatively with biological functions.
Ziad A. Massy, Sophie Liabeuf, Tilman B. Drüeke   +2 more
doaj   +1 more source

AST-120 for the management of progression of chronic kidney disease

International Journal of Nephrology and Renovascular Disease, 2014
Gerald Schulman,1 Raymond Vanholder,2 Toshimitsu Niwa31Vanderbilt University School of Medicine, Nashville, TN, USA; 2University Hospital, Ghent, Belgium; 3Nagoya University Graduate School of Medicine, Nagoya, JapanAbstract: Uremic toxins such as ...
Schulman G, Vanholder R, Niwa T
doaj  

Alterations in gut‐derived uremic toxins before the onset of azotemic chronic kidney disease in cats

Journal of Veterinary Internal Medicine
Background Although gut‐derived uremic toxins are increased in azotemic chronic kidney disease (CKD) in cats and implicated in disease progression, it remains unclear if augmented formation or retention of these toxins is associated with the development ...
Laurens Van Mulders, Ellen Vanden Broecke, Ellen De Paepe, Femke Mortier, Lynn Vanhaecke, Sylvie Daminet   +5 more
doaj   +1 more source

Gut microbiota dysbiosis and amino acid metabolic dysregulation in children with allergic rhinitis complicated by constipation

Microbiology Spectrum
This study investigates the pathogenesis of constipation in children with allergic rhinitis (AR) by analyzing gut microbiota (GM) composition and fecal metabolites.
Shen Lv, Weikeng Yang, Chunyun Sun, Ying Huang, Wei Kong, Zhi Wan, Congfu Huang   +6 more
doaj   +1 more source

Dietary protein intake and the tubular handling of indoxyl sulfate

Nephrology Dialysis Transplantation
ABSTRACT Background Chronic kidney disease (CKD) patients are advised to limit their protein intake. A high protein diet is known to induce glomerular hyperfiltration, as well as hypertrophy of the remnant kidney, and glomerulosclerosis.
Lauriola, Mara, Farre, Ricard, Dejongh, Sander, de Loor, Henriette, Evenepoel, Pieter, Masereeuw, Rosalinde, Zadora, Ward, Meijers, Bjorn   +7 more
openaire   +2 more sources

Serum metabolomics identifies gut-derived uremic toxins and bile acid dysregulation associated with chronic kidney disease severity

Scientific Reports
Chronic kidney disease (CKD) affects more than 700 million people worldwide, however conventional biomarkers like creatinine cannot identify early-stage disease or accurately predict progression.
Nehal Y. Mansour, Manal F. Ismail, Noha H. Sayed, Amira R. El-Ansary, Marwa Mohanad   +4 more
doaj   +1 more source

The Choice of Anti-Inflammatory Influences the Elimination of Protein-Bound Uremic Toxins

Toxins
Pain is a frequent and disturbing symptom among hemodialysis patients. Protein-bound uremic toxins (PBUTs) are related to cardiovascular and overall mortality, and they are difficult to remove with current hemodialysis treatments.
Víctor Joaquín Escudero-Saiz, Elena Cuadrado-Payán, María Rodriguez-Garcia, Gregori Casals, Lida María Rodas, Néstor Fontseré, María del Carmen Salgado, Carla Bastida, Nayra Rico, José Jesús Broseta, Francisco Maduell   +10 more
doaj   +1 more source

Indoxyl Sulfate Suppresses Hpdlc Osteogenesis Through Ferroptosis

International Dental Journal
Aim or purpose: Human periodontal ligament stem cells (hPDLCs) play pivotal roles in periodontal tissue repair and bone regeneration. This study investigated the inhibitory effects and underlying mechanisms of indoxyl sulfate (IS), a uremic toxin, on the
Huiwen Chen, Zhongchen Song
doaj   +1 more source