Results 81 to 90 of about 7,345 (172)

Cancer Risk in Haemodialysis Patients Compared With That in the General Population: A Multicenter Questionnaire‐Based Study in Okinawa, Japan

Nephrology, Volume 31, Issue 10, October 2026.
This multicenter study evaluated cancer risk among haemodialysis patients in Okinawa, Japan. The risk of colorectal and lung cancer was particularly increased during the first 2 years of dialysis, highlighting the importance of cancer screening during this period.
Yoko Arakawa, Yuriko Ishida, Akira Higa, Takeshi Tana, Takuhiro Moromizato, Kentaro Kohagura, Kunitoshi Iseki   +6 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, Volume 16, Issue 9, Page 1645-1656, September 2026.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, Volume 13, Issue 51, 14 September 2026.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

The double‐edged sword of endoplasmic reticulum stress in uremic sarcopenia through myogenesis perturbation

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background Sarcopenia is the age‐related degeneration characterized with the decline of skeletal muscle mass, strength, and function. The imbalance of protein synthesis and degradation which jeopardizes immune, hormone regulation, and muscle‐motor neuron
Jia‐Rong Jheng, Yuan‐Siao Chen, Un Iong Ao, Ding‐Cheng Chan, Jenq‐Wen Huang, Kuang‐Yu Hung, Der‐Cheng Tarng, Chih‐Kang Chiang   +7 more
doaj   +1 more source

Protein-Bound Uremic Toxins: New Insight from Clinical Studies

Toxins, 2011
The uremic syndrome is attributed to the progressive retention of a large number of compounds which, under normal conditions, are excreted by healthy kidneys. The compounds are called uremic toxins when they interact negatively with biological functions.
Ziad A. Massy, Sophie Liabeuf, Tilman B. Drüeke   +2 more
doaj   +1 more source

AST-120 for the management of progression of chronic kidney disease

International Journal of Nephrology and Renovascular Disease, 2014
Gerald Schulman,1 Raymond Vanholder,2 Toshimitsu Niwa31Vanderbilt University School of Medicine, Nashville, TN, USA; 2University Hospital, Ghent, Belgium; 3Nagoya University Graduate School of Medicine, Nagoya, JapanAbstract: Uremic toxins such as ...
Schulman G, Vanholder R, Niwa T
doaj  

Alterations in gut‐derived uremic toxins before the onset of azotemic chronic kidney disease in cats

Journal of Veterinary Internal Medicine
Background Although gut‐derived uremic toxins are increased in azotemic chronic kidney disease (CKD) in cats and implicated in disease progression, it remains unclear if augmented formation or retention of these toxins is associated with the development ...
Laurens Van Mulders, Ellen Vanden Broecke, Ellen De Paepe, Femke Mortier, Lynn Vanhaecke, Sylvie Daminet   +5 more
doaj   +1 more source

Gut microbiota dysbiosis and amino acid metabolic dysregulation in children with allergic rhinitis complicated by constipation

Microbiology Spectrum
This study investigates the pathogenesis of constipation in children with allergic rhinitis (AR) by analyzing gut microbiota (GM) composition and fecal metabolites.
Shen Lv, Weikeng Yang, Chunyun Sun, Ying Huang, Wei Kong, Zhi Wan, Congfu Huang   +6 more
doaj   +1 more source

Dietary protein intake and the tubular handling of indoxyl sulfate

Nephrology Dialysis Transplantation
ABSTRACT Background Chronic kidney disease (CKD) patients are advised to limit their protein intake. A high protein diet is known to induce glomerular hyperfiltration, as well as hypertrophy of the remnant kidney, and glomerulosclerosis.
Lauriola, Mara, Farre, Ricard, Dejongh, Sander, de Loor, Henriette, Evenepoel, Pieter, Masereeuw, Rosalinde, Zadora, Ward, Meijers, Bjorn   +7 more
openaire   +2 more sources

Serum metabolomics identifies gut-derived uremic toxins and bile acid dysregulation associated with chronic kidney disease severity

Scientific Reports
Chronic kidney disease (CKD) affects more than 700 million people worldwide, however conventional biomarkers like creatinine cannot identify early-stage disease or accurately predict progression.
Nehal Y. Mansour, Manal F. Ismail, Noha H. Sayed, Amira R. El-Ansary, Marwa Mohanad   +4 more
doaj   +1 more source