Toxins, 2017 If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Mario Vaneechoutte +2 more
exaly +10 more sources
Molecular and Cellular Mechanisms that Induce Arterial Calcification by Indoxyl Sulfate and P-Cresyl Sulfate [PDF]
Toxins, 2020 The protein-bound uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate (PCS), are considered to be harmful vascular toxins. Arterial media calcification, or the deposition of calcium phosphate crystals in the arteries, contributes significantly to ...
Britt Opdebeeck +2 more
doaj +7 more sources
The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients [PDF]
Scientific Reports, 2021 Protein-bound uremic toxins (Indoxyl sulfate [IS] and p-cresyl sulfate [PCS]) are both associated with cardiovascular (CV) and all-cause mortality in subjects with chronic kidney disease (CKD). Possible mechanisms have not been elucidated.
Ping-Hsun Wu +10 more
doaj +7 more sources
Phenyl sulfate, indoxyl sulfate and p-cresyl sulfate decrease glutathione level to render cells vulnerable to oxidative stress in renal tubular cells. [PDF]
PLoS ONE, 2018 In chronic kidney disease patients, oxidative stress is generally associated with disease progression and pathogenesis of its comorbidities. Phenyl sulfate is a protein-bound uremic solute, which accumulates in chronic kidney disease patients, but little
Takeo Edamatsu +2 more
doaj +6 more sources
Serum P-Cresyl Sulfate Is Associated with Peripheral Arterial Stiffness in Chronic Hemodialysis Patients [PDF]
DiagnosticsBackground/Objectives: Arterial stiffness is a major cardiovascular risk factor in patients with hemodialysis (HD). We conducted a cross-sectional study aimed at determining the relationship between serum p-Cresyl sulfate (PCS) and peripheral arterial ...
Yahn-Bor Chern +5 more
doaj +6 more sources
Unambiguous Characterization of p-Cresyl Sulfate, a Protein-Bound Uremic Toxin, as Biomarker of Heart and Kidney Disease [PDF]
Molecules, 2019 p-Cresyl sulfate is one of the bound uremic toxins whose level increases in the sera of patients with the severity of chronic kidney disease and is therefore used as a standard for clinical investigations.
Rita Paroni +5 more
doaj +4 more sources
Altered Gut Microbiota and Gut-Derived p-Cresyl Sulfate Serum Levels in Peritoneal Dialysis Patients [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Peritoneal dialysis (PD) is a renal replacement therapy for end-stage renal disease. Gut microbiota-derived uremic solutes, indoxyl sulfate (IS), p-cresyl sulfate (PCS), and trimethylamine-N-oxide (TMAO) accumulate in PD patients.
Xiaoqiang Ding +2 more
exaly +4 more sources
Serum P-Cresyl Sulfate Levels Correlate with Peripheral Arterial Disease in Hypertensive Patients [PDF]
DiagnosticsBackground/Objectives: p-Cresyl sulfate (PCS) is implicated in inflammation, oxidative stress and vascular dysfunction. Hypertension is a major risk factor for peripheral arterial disease (PAD), which is linked to increased mortality in patients with ...
Yahn-Bor Chern +4 more
doaj +3 more sources
Gamma-tocopherol vitamin E enhances the cytotoxicity of p-cresyl sulfate to renal tubular cells [PDF]
European Journal of Medical ResearchBackground The protein-bound uremic toxins p-cresyl sulfate (PCS) and indoxyl sulfate (IS) are commonly found at elevated levels in patients with chronic kidney disease and can promote oxidative stress leading to the progression of renal disease. However,
Chyou-Wei Wei +8 more
doaj +4 more sources
Elevated p-Cresyl Sulfate Levels Are Associated with Impaired Endothelial Function in Patients Undergoing Long-Term Peritoneal Dialysis [PDF]
Lifep-Cresyl sulfate (PCS) is associated with endothelial injury and adverse cardiovascular outcomes. However, its association with endothelial function in patients on peritoneal dialysis (PD) remains unclear.
I-Min Su +4 more
doaj +2 more sources