Toxins, 2017 If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Tessa Gryp +3 more
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The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients [PDF]
Scientific Reports, 2021 Protein-bound uremic toxins (Indoxyl sulfate [IS] and p-cresyl sulfate [PCS]) are both associated with cardiovascular (CV) and all-cause mortality in subjects with chronic kidney disease (CKD). Possible mechanisms have not been elucidated.
Ping-Hsun Wu +10 more
doaj +6 more sources
Molecular and Cellular Mechanisms that Induce Arterial Calcification by Indoxyl Sulfate and P-Cresyl Sulfate [PDF]
Toxins, 2020 The protein-bound uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate (PCS), are considered to be harmful vascular toxins. Arterial media calcification, or the deposition of calcium phosphate crystals in the arteries, contributes significantly to ...
Britt Opdebeeck +2 more
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Altered gut microbiota and gut-derived p-cresyl sulfate serum levels in peritoneal dialysis patients [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Peritoneal dialysis (PD) is a renal replacement therapy for end-stage renal disease. Gut microbiota-derived uremic solutes, indoxyl sulfate (IS), p-cresyl sulfate (PCS), and trimethylamine-N-oxide (TMAO) accumulate in PD patients.
Manchen Bao +27 more
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Phenyl sulfate, indoxyl sulfate and p-cresyl sulfate decrease glutathione level to render cells vulnerable to oxidative stress in renal tubular cells. [PDF]
PLoS ONE, 2018 In chronic kidney disease patients, oxidative stress is generally associated with disease progression and pathogenesis of its comorbidities. Phenyl sulfate is a protein-bound uremic solute, which accumulates in chronic kidney disease patients, but little
Takeo Edamatsu +2 more
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-Cresyl sulfate and indoxyl sulfate in pediatric patients on chronic dialysis [PDF]
Korean Journal of Pediatrics, 2013 PurposeIndoxyl sulfate and p-cresyl sulfate are important protein-bound uremic retention solutes whose levels can be partially reduced by renal replacement therapy. These solutes originate from intestinal bacterial protein fermentation and are associated
Hye Sun Hyun +2 more
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Heritability and clinical determinants of serum indoxyl sulfate and p-cresyl sulfate, candidate biomarkers of the human microbiome enterotype. [PDF]
PLoS ONE, 2014 BackgroundIndoxyl sulfate and p-cresyl sulfate are unique microbial co-metabolites. Both co-metabolites have been involved in the pathogenesis of accelerated cardiovascular disease and renal disease progression.
Liesbeth Viaene +8 more
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Serum P-Cresyl Sulfate Is Associated with Peripheral Arterial Stiffness in Chronic Hemodialysis Patients [PDF]
DiagnosticsBackground/Objectives: Arterial stiffness is a major cardiovascular risk factor in patients with hemodialysis (HD). We conducted a cross-sectional study aimed at determining the relationship between serum p-Cresyl sulfate (PCS) and peripheral arterial ...
Yahn-Bor Chern +5 more
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Unambiguous Characterization of p-Cresyl Sulfate, a Protein-Bound Uremic Toxin, as Biomarker of Heart and Kidney Disease [PDF]
Molecules, 2019 p-Cresyl sulfate is one of the bound uremic toxins whose level increases in the sera of patients with the severity of chronic kidney disease and is therefore used as a standard for clinical investigations.
Rita Paroni +5 more
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Gamma-tocopherol vitamin E enhances the cytotoxicity of p-cresyl sulfate to renal tubular cells [PDF]
European Journal of Medical ResearchBackground The protein-bound uremic toxins p-cresyl sulfate (PCS) and indoxyl sulfate (IS) are commonly found at elevated levels in patients with chronic kidney disease and can promote oxidative stress leading to the progression of renal disease. However,
Chyou-Wei Wei +8 more
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