Results 1 to 10 of about 7,413 (211)

Furosemide and Serum Protein-Bound Uremic Toxin Concentrations in Patients With CKD [PDF]

Kidney International Reports
Introduction: Furosemide is commonly prescribed to patients with chronic kidney disease (CKD) but may impair the kidney’s excretion of protein-bound uremic toxins (PBUTs) via the organic anion transporters 1 and 3 (OAT1 and OAT3).
Margaux Costes-Albrespic, Natalia Alencar de Pinho, Islam Amine Larabi, Carolla El Chamieh, Solène M. Laville, Denis Fouque, Maurice Laville, Luc Frimat, Jean-Claude Alvarez, Ziad A. Massy, Sophie Liabeuf, Natalia Alencar De Pinho, Dorothée Cannet, Christian Combe, Denis Fouque, Luc Frimat, Aghilès Hamroun, Yves-Edouard Herpe, Christian Jacquelinet, Maurice Laville, Sophie Liabeuf, Ziad A. Massy, Pascal Morel, Christophe Pascal, Roberto Pecoits-Filho, Joost Schanstra, Bénédicte Stengel, Céline Lange, Oriane Lambert, Marie Metzger   +29 more
doaj   +5 more sources

Protein-Bound Uremic Toxin Profiling as a Tool to Optimize Hemodialysis. [PDF]

PLoS ONE, 2016
AIM:We studied various hemodialysis strategies for the removal of protein-bound solutes, which are associated with cardiovascular damage. METHODS:This study included 10 patients on standard (3 x 4 h/week) high-flux hemodialysis.
Sunny Eloot, Daniel Schneditz, Tom Cornelis, Wim Van Biesen, Griet Glorieux, Annemie Dhondt, Jeroen Kooman, Raymond Vanholder   +7 more
doaj   +7 more sources

Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients. [PDF]

PLoS ONE, 2017
Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points.
Sunny Eloot, Wim Van Biesen, Sanne Roels, Willem Delrue, Eva Schepers, Annemieke Dhondt, Raymond Vanholder, Griet Glorieux   +7 more
doaj   +19 more sources

p-Cresyl Sulfate [PDF]

Toxins, 2017
If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Tessa Gryp, Raymond Vanholder, Mario Vaneechoutte, Griet Glorieux   +3 more
doaj   +7 more sources

Optimization of Ibuprofen Route and Dosage to Enhance Protein-Bound Uremic Toxin Clearance During Hemodialysis [PDF]

Toxins
Protein-bound uremic toxins (PBUT), particularly indoxyl sulphate (IS) and p-cresyl sulphate (pCS), are poorly removed by conventional haemodialysis because of their strong albumin binding.
Víctor Joaquín Escudero-Saiz, Elena Cuadrado-Payán, María Rodríguez-García, Gregori Casals, Lida María Rodas, Néstor Fontseré, María del Carmen Salgado, Carla Bastida, Nayra Rico, José Jesús Broseta, Francisco Maduell   +10 more
doaj   +2 more sources

P-Cresylsulfate, the Protein-Bound Uremic Toxin, Increased Endothelial Permeability Partly Mediated by Src-Induced Phosphorylation of VE-Cadherin [PDF]

Toxins, 2020
The goal of our study was to investigate the impact of p-cresylsulfate (PCS) on the barrier integrity in human umbilical vein endothelial cell (HUVEC) monolayers and the renal artery of chronic kidney disease (CKD) patients.
Shih-Chieh Chen, Shin-Yin Huang, Chia-Chun Wu, Chiung-Fang Hsu   +3 more
doaj   +2 more sources

Protein-bound uremic toxin clearance as biomarker of kidney tubular function in diabetic kidney disease [PDF]

Scientific Reports
Kidney tubular damage is an important prognostic determinant in diabetic kidney disease (DKD). A vital homeostatic function of the proximal tubule is active tubular secretion of waste products via organic anion transporters (OATs), including protein ...
Sabbir Ahmed, Rolf W. Sparidans, Robin W. M. Vernooij, Silvia M. Mihaila, Roel Broekhuizen, Roel Goldschmeding, Tri Q. Nguyen, Rosalinde Masereeuw, Karin G. F. Gerritsen   +8 more
doaj   +2 more sources

Comprehensive Bibliometric Analysis of Uremic Toxin Research [PDF]

Toxins
Uremic toxins accumulate as kidney disease progresses, contributing to diverse systemic disorders. Despite numerous studies, no comprehensive mapping has been performed.
Marsuki Hardjo, Takuya Wakamatsu, Kazuki Watanabe, Shoko Yamazaki, Suguru Yamamoto   +4 more
doaj   +2 more sources

Uremic Toxins and Protein-Bound Therapeutics in AKI and CKD: Up-to-Date Evidence

Toxins, 2021
Uremic toxins are defined as harmful metabolites that accumulate in the human body of patients whose renal function declines, especially chronic kidney disease (CKD) patients. Growing evidence demonstrates the deteriorating effect of uremic toxins on CKD
Jia-Huang Chen, Chih-Kang Chiang
doaj   +1 more source

The Dual Roles of Protein-Bound Solutes as Toxins and Signaling Molecules in Uremia

Toxins, 2022
In patients with severe kidney disease, renal clearance is compromised, resulting in the accumulation of a plethora of endogenous waste molecules that cannot be removed by current dialysis techniques, the most often applied treatment.
Rosalinde Masereeuw
doaj   +1 more source