Results 41 to 50 of about 7,413 (211)
Protein-bound uremic toxins impaired mitochondrial dynamics and functions
Oncotarget, 2017 Protein-bound uremic toxins, indoxyl sulfate and p-cresol sulfate, increase oxidative stress and adversely affect chronic kidney disease progression and cardiovascular complications. In this study, we examined whether mitochondria are the target of indoxyl sulfate and p-cresol sulfate intoxication in vivo and in vitro. The kidneys of 10-week-old male B-
Sun, Chiao-Yin +4 more
openaire +3 more sources
mSphere, 2022 Renal impairment associated with chronic kidney disease (CKD) causes the buildup of uremic toxins that are deleterious to patient health. Current therapies that manage toxin accumulation in CKD offer an incomplete therapeutic effect against toxins such ...
Gerrit A. Stuivenberg +4 more
doaj +1 more source
Bisphenol A in chronic kidney disease [PDF]
, 2013 Phenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment and vascular damage. Bisphenol A (BPA) is a molecule with
Bosch, Ricardo J. +5 more
core +4 more sources
pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro
Toxins, 2021 Protein-bound uremic toxins (PBUTs) are difficult to remove using conventional dialysis treatment owing to their high protein-binding affinity. As pH changes the conformation of proteins, it may be associated with the binding of uremic toxins.
Suguru Yamamoto +7 more
doaj +1 more source
Associação entre indoxil sulfato e histomorfometria óssea em pacientes renais crônicos pré-diálise [PDF]
, 2014 Introduction: Experimental studies have suggested that indoxyl sulfate (IS), a protein-bound uremic toxin, may be involved in the development of renal osteodystrophy.
Barreto, Daniela Veit +9 more
core +4 more sources
Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome. [PDF]
PLoS ONE, 2017 Intracellular accumulation of protein-bound uremic toxins in the setting of cardiorenal syndrome leads to adverse effects on cardiorenal cellular functions, where cardiac hypertrophy and cardiorenal fibrosis are the hallmarks. In this study, we sought to
Feby Savira +12 more
doaj +1 more source
Toxins, 2021 Optical monitoring of spent dialysate has been used to estimate the removal of water-soluble low molecular weight as well as protein-bound uremic toxins from the blood of end stage kidney disease (ESKD) patients.
Joosep Paats +7 more
doaj +1 more source
Research advances in the mechanisms of indoxyl sulfate and sarcopenia in chronic kidney disease
Linchuang shenzangbing zazhiSarcopenia in chronic kidney disease （CKD） occurs mainly in patients with end-stage renal disease （ESRD） on hemodialysis. The potential causes are insufficient nutrition intake, protein and energy consumption, inflammatory cytokines, oxidative stress ...
Shu-yuan Yang, Yan Zhang, Yan-kun Luo
doaj +1 more source
Protein-Bound Uremic Toxins Induce Tissue Remodeling by Targeting the EGF Receptor [PDF]
Journal of the American Society of Nephrology, 2015 Indoxyl sulfate and p-cresol sulfate have been suggested to induce kidney tissue remodeling. This study aimed to clarify the molecular mechanisms underlying this tissue remodeling using cultured human proximal renal tubular cells and half-nephrectomized mice treated with indoxyl sulfate or p-cresol sulfate as study models.
Chiao-Yin, Sun +7 more
openaire +2 more sources
, 2017 Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by intravascular hemolysis, thrombocytopenia, and acute kidney failure. HUS is usually categorized as typical, caused by Shiga toxin-producing Escherichia coli (STEC) infection,
Al-Nouri +135 more
core +1 more source