Results 41 to 50 of about 4,792 (191)

Improving immune function and mitochondrial health in patients undergoing hemodialysis: benefits of combining high-flux dialysis with hemoperfusion [PDF]

Frontiers in Medicine
ObjectiveThis study aimed to investigate the effects of combining hemoperfusion (HP) with high-flux hemodialysis (HFD) on T lymphocyte subsets, mitochondrial health, and clinical outcomes in patients undergoing maintenance hemodialysis (MHD).MethodsIn ...
Qi Zhong, Qiudi Tu, Baoqiao Wu, Yuemin Liu, Yiwen Li, Bo Lin, Bin Zhu, Yan Ren   +7 more
doaj   +2 more sources

Vasculopathy in the setting of cardiorenal syndrome: roles of protein-bound uremic toxins [PDF]

American Journal of Physiology-Heart and Circulatory Physiology, 2017
Chronic kidney disease (CKD) often leads to and accelerates the progression of cardiovascular disease (CVD), while CVD also causes kidney dysfunction. This bidirectional interaction leads to the development of a complex syndrome known as cardiorenal syndrome (CRS). CRS not only involves both the heart and the kidney but also the vascular system through
Jingbin, Guo, Lu, Lu, Yue, Hua, Kevin, Huang, Ian, Wang, Li, Huang, Qiang, Fu, Aihua, Chen, Paul, Chan, Huimin, Fan, Zhong-Min, Liu, Bing Hui, Wang   +11 more
openaire   +5 more sources

The Medium Cut-Off Membrane Does Not Lower Protein-Bound Uremic Toxins

Toxins, 2022
The accumulation of protein-bound uremic toxins (PBUT) is associated with increased cardiovascular outcomes in patients on dialysis. However, the efficacy of PBUT removal for a medium-cutoff (MCO) membrane has not been clarified.
Yang Gyun Kim, Sang Ho Lee, Su Woong Jung, Gun Tae Jung, Hyun Ji Lim, Kwang Pyo Kim, Young-Il Jo, KyuBok Jin, Ju Young Moon   +8 more
doaj   +4 more sources

Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study [PDF]

Renal Failure
Objective To delineate the efficacy and safety profile of hemodiafiltration with endogenous reinfusion (HFR) for uremic toxin removal in patients undergoing maintenance hemodialysis (MHD).Methods Patients who have been on MHD for a period of at least 3 ...
Renhua Lu, Yan Fang, Wangshu Wu, Xiaojun Zeng, Tingting Liu, Yue Qian, Yuanyuan Xie, Yijun Zhou, Leyi Gu   +8 more
doaj   +2 more sources

The uremic toxin indoxyl sulphate enhances macrophage response to LPS. [PDF]

PLoS ONE, 2013
Indoxyl sulphate (IS) is a protein-bound uremic toxin that results from the metabolism of dietary tryptophan normally excreted by kidney through the proximal tubules.
Simona Adesso, Ada Popolo, Giuseppe Bianco, Rosalinda Sorrentino, Aldo Pinto, Giuseppina Autore, Stefania Marzocco   +6 more
doaj   +4 more sources

Comparison of uremic toxin removal between expanded hemodialysis and high volume online hemodiafiltrations in different modes [PDF]

Acta Biochimica Polonica
Various high-efficiency hemodialysis techniques exist, including different online high- volume hemodiafiltration (HDF) modes and expanded hemodialysis (HDx) utilizing dialyzers with medium cut-off (MCO) membranes.
Jan Biedunkiewicz, Agnieszka Zakrzewska, Sylwia Małgorzewicz, Michał Komorniczak, Katarzyna Jasiulewicz, Natalia Płonka, Agnieszka Tarasewicz, Magdalena Jankowska, Bogdan Biedunkiewicz, Alicja Dębska‐Ślizień, Leszek Tylicki   +10 more
doaj   +3 more sources

Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis

Biomedicines, 2023
Chronic kidney disease (CKD) is a progressive condition of kidney dysfunction due to diverse causes of injury. In healthy kidneys, protein-bound uremic toxins (PBUTs) are cleared from the systemic circulation by proximal tubule cells through the concerted action of plasma membrane transporters that facilitate their urinary excretion, but the endogenous
Yi Yang, Milos Mihajlovic, Rosalinde Masereeuw   +2 more
openaire   +7 more sources

Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes [PDF]

Toxins, 2019
To better understand the kinetics of protein-bound uremic toxins (PBUTs) during hemodialysis (HD), we investigated the distribution of hippuric acid (HA), indole-3-acetic acid (IAA), indoxyl sulfate (IS), and p-cresyl sulfate (pCS) in erythrocytes of HD patients.
Olivier Deltombe, Griet Glorieux, Sami Marzouki, Rosalinde Masereeuw, Daniel Schneditz, Sunny Eloot   +5 more
openaire   +5 more sources

Protein/Fiber Index Modulates Uremic Toxin Concentrations in Hemodialysis Patients [PDF]

, 2022
Background: Indoxyl sulfate (IS) and p-cresyl sulfate (PCS), two uremic toxins (UTs), are associated with increased mortality in patients with chronic kidney disease (CKD).
Cecilia Mallmann, Bouchouareb, Dammar, Manon Ebersolt, Mc-Kay, Nathalie, Dou, Laetitia, Nathalie Mc-Kay, Marion Sallée, Santana Machado, Tacy, Tacy Santana Machado, Laetitia Dou, Mallmann, Cecilia, Philippe Brunet, Stéphane Burtey, Brunet, Philippe, Sallée, Marion, Dammar Bouchouareb, Ebersolt, Manon, Burtey, Stéphane   +17 more
core   +1 more source

Strategies for Removal of Protein-Bound Uremic Toxins in Hemodialysis. [PDF]

Toxins (Basel)
The removal of protein-bound uremic toxins (PBUTs) from the blood of kidney failure patients with conventional dialysis is limited. However, as their harmful effects and association with morbidity and mortality in dialysis patients are increasingly recognized, PBUTs have become important therapeutic targets.
de Vries JC, Brás JG, de Vries GM, Vollenbroek JC, Wieringa FP, Jankowski J, Verhaar MC, Stamatialis D, Masereeuw R, Gerritsen KGF.   +9 more
europepmc   +5 more sources